Results 21 to 30 of about 853 (171)

The Dynamic Influence of Olorofim (F901318) on the Cell Morphology and Organization of Living Cells of Aspergillus fumigatus [PDF]

Journal of Fungi, 2020
The first characterized antifungal in the orotomide class is olorofim. It targets the de novo pyrimidine biosynthesis pathway by inhibiting dihydroorotate dehydrogenase (DHODH).
Saskia du Pré, Mike Birch, Derek Law, Nicola Beckmann, Graham E. M. Sibley, Michael J. Bromley, Nick D. Read, Jason D. Oliver   +7 more
doaj   +4 more sources

A case of Lomentospora prolificans endophthalmitis treated with the novel antifungal agent Olorofim

Journal of Ophthalmic Inflammation and Infection
Purpose To report a case of endogenous Lomentospora prolificans endophthalmitis treated with the novel antifungal agent Olorofim. Case report A 57-year-old man developed disseminated Lomentospora prolificans with right endophthalmitis on the background ...
Michael Dong, Fiona Pearce, Nandini Singh, Ming-Lee Lin   +3 more
doaj   +3 more sources

High-Risk Neutropenic Fever and Invasive Fungal Diseases in Patients with Hematological Malignancies [PDF]

Microorganisms
Invasive fungal diseases (IFDs) still represent a relevant cause of mortality in patients affected by hematological malignancies, especially acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS) undergoing remission induction chemotherapy, and
Giovanni Mori, Sara Diotallevi, Francesca Farina, Riccardo Lolatto, Laura Galli, Matteo Chiurlo, Andrea Acerbis, Elisabetta Xue, Daniela Clerici, Sara Mastaglio, Maria Teresa Lupo Stanghellini, Marco Ripa, Consuelo Corti, Jacopo Peccatori, Massimo Puoti, Massimo Bernardi, Antonella Castagna, Fabio Ciceri, Raffaella Greco, Chiara Oltolini   +19 more
doaj   +3 more sources

The Antifungal Pipeline: Fosmanogepix, Ibrexafungerp, Olorofim, Opelconazole, and Rezafungin [PDF]

Drugs, 2021
The epidemiology of invasive fungal infections is changing, with new populations at risk and the emergence of resistance caused by the selective pressure from increased usage of antifungal agents in prophylaxis, empiric therapy, and agriculture. Limited antifungal therapeutic options are further challenged by drug-drug interactions, toxicity, and ...
Martin Hoenigl, Rosanne Sprute, Matthias Egger, Amir Arastehfar, Oliver A. Cornely, Robert Krause, Cornelia Lass-Flörl, Juergen Prattes, Andrej Spec, George R. Thompson, Nathan Wiederhold, Jeffrey D. Jenks   +11 more
openaire   +4 more sources

Olorofim is potent against Madurella mycetomatis – the most common causative agent of Eumycetoma [PDF]

International Journal of Infectious Diseases, 2020
W. Lim, K. Eadie, B. Rijnders, A. Fahal, J. Oliver, M. Birch, W. van de Sande   +6 more
doaj   +2 more sources

An update on the development of novel antifungal agents for eumycetoma [PDF]

, 2023
Eumycetoma, a chronic subcutaneous mycosis, responds poorly to the available antifungal treatments and patients often require extensive surgical resection or amputation of the affected limb. More effective treatments are needed for eumycetoma.
Bonifaz, Alexandro, Chandler, David, van de Sande, Wendy   +2 more
core   +2 more sources

Olorofim activity against multidrug-resistant Fusarium unveils intra-species and inter-species variability. [PDF]

Antimicrob Agents Chemother
ABSTRACT Fungi in the genus Fusarium are plant pathogens but are also capable of causing a wide range of diseases in humans.
Xue R, Gao S, de Hoog S, van Diepeningen A, Zhou S, Xu T, Fokkens L, Li R, Bai L, Wan Z, Verweij PE, Song Y.   +11 more
europepmc   +2 more sources

Pandemic Response Box® library as a source of antifungal drugs against Scedosporium and Lomentospora species

PLoS ONE, 2023
Scedosporium and Lomentospora species are opportunistic filamentous fungi that cause localized and disseminated infections in immunocompetent and immunocompromised patients.
Rodrigo Rollin-Pinheiro, Mariana Ingrid Dutra da Silva Xisto, Yuri de Castro-Almeida, Victor Pereira Rochetti, Luana Pereira Borba-Santos, Yasmin da Silva Fontes, Antonio Ferreira-Pereira, Sonia Rozental, Eliana Barreto-Bergter   +8 more
doaj   +3 more sources

Antagonistic interaction between posaconazole and olorofim in a murine model of invasive pulmonary aspergillosis. [PDF]

J Antimicrob Chemother
Abstract Background Olorofim is a new antifungal agent with a novel mechanism of action with in vitro activity against Aspergillus fumigatus and other clinically important moulds. As antifungal combinations are of interest to extend the spectrum of coverage and improve antifungal activity, we ...
Darlow CA, Farrington N, Märtson AG, Johnson A, McEntee L, Horner I, Stevenson A, Jimenez-Valverde A, Unsworth J, Das S, Hope W.   +10 more
europepmc   +2 more sources

Diagnosis and Treatment of Invasive Aspergillosis Caused by Non-fumigatus Aspergillus spp. [PDF]

, 2023
With increasing frequency, clinical and laboratory-based mycologists are consulted on invasive fungal diseases caused by rare fungal species. This review aims to give an overview of the management of invasive aspergillosis (IA) caused by non-fumigatus ...
Ackermann, Katharina, Cornely, Oliver Andreas, Koehler, Philipp, Lass-Flörl, Cornelia, Rath, Peter-Michael, Simon, Michaela, Steinmann, Jörg, Stemler, Jannik, Többen, Christina   +8 more
core   +1 more source