Review of the novel antifungal drug olorofim (F901318) [PDF]
BMC Infectious DiseasesThere is clearly a need for novel antifungal agents, not only concerning spectrum, but also oral bioavailability, tolerability, and drug-drug interactions.
Yuri Vanbiervliet +5 more
doaj +5 more sources
Olorofim demonstrates in vitro activity against Coccidioides species, including isolates against which fluconazole has reduced activity. [PDF]
Antimicrobial Agents and ChemotherapyWe evaluated the in vitro activity of olorofim against Coccidioides species. Olorofim demonstrated potent in vitro activity against all isolates tested with a minimum inhibitory concentration (MIC) range ≤0.008-0.06 µg/mL and geometric mean MIC of 0.010 ...
Ferrer, Dora +5 more
core +6 more sources
Refractory Microascus Bronchopulmonary Infection Treated with Olorofim, France
Emerging Infectious Diseases, 2023 We report 3 cases of successful treatment of Microascus spp. bronchopulmonary infection in a multiple-traumatized patient and 2 lung transplant recipients in France.
Emmanuel Faure +10 more
doaj +3 more sources
Correction: Review of the novel antifungal drug olorofim (F901318) [PDF]
BMC Infectious DiseasesYuri Vanbiervliet +5 more
doaj +3 more sources
Anti-Aspergillus activities of olorofim at sub-MIC levels during early-stage growth
Microbiology SpectrumOlorofim, the first member of the novel class of antifungal drugs, the orotomides, shows promising anti-Aspergillus activity and is currently in phase III clinical development.
Alexander Kühbacher +3 more
doaj +3 more sources
Olorofim activity against multidrug-resistant Fusarium unveils intra-species and inter-species variability [PDF]
Antimicrobial Agents and ChemotherapyABSTRACT Fungi in the genus Fusarium are plant pathogens but are also capable of causing a wide range of diseases in humans.
Ruoning Xue +11 more
openaire +2 more sources
Lomentospora prolificans infective endocarditis and cerebral mycotic aneurysm [PDF]
Medical Mycology Case ReportsDisseminated Lomentospora prolificans infection typically occurs in immunocompromised hosts and is almost universally fatal. We describe a case of L.
Robert Hand +5 more
doaj +2 more sources
Bury my axe in wounded knee: A case of native knee septic arthritis caused by multidrug resistant Lomentospora prolificans [PDF]
Medical Mycology Case ReportsA 39-year-old male presenting with swelling and pain in the left knee after traumatic injury was diagnosed with rapidly progressive septic arthritis of the knee due to pan-resistant Lomentospora prolificans. While L. prolificans is an environmental mold,
Weston Carpenter +6 more
doaj +2 more sources
Antagonistic interaction between posaconazole and olorofim in a murine model of invasive pulmonary aspergillosis [PDF]
Journal of Antimicrobial ChemotherapyAbstract Background Olorofim is a new antifungal agent with a novel mechanism of action with in vitro activity against Aspergillus fumigatus and other clinically important moulds. As antifungal combinations are of interest to extend the spectrum of coverage and improve antifungal activity, we ...
Christopher A Darlow +10 more
openaire +2 more sources
The Dynamic Influence of Olorofim (F901318) on the Cell Morphology and Organization of Living Cells of Aspergillus fumigatus [PDF]
Journal of Fungi, 2020 The first characterized antifungal in the orotomide class is olorofim. It targets the de novo pyrimidine biosynthesis pathway by inhibiting dihydroorotate dehydrogenase (DHODH).
Saskia du Pré +7 more
doaj +4 more sources