Results 31 to 40 of about 895 (178)

High-Risk Neutropenic Fever and Invasive Fungal Diseases in Patients with Hematological Malignancies [PDF]

Microorganisms
Invasive fungal diseases (IFDs) still represent a relevant cause of mortality in patients affected by hematological malignancies, especially acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS) undergoing remission induction chemotherapy, and
Giovanni Mori, Sara Diotallevi, Francesca Farina, Riccardo Lolatto, Laura Galli, Matteo Chiurlo, Andrea Acerbis, Elisabetta Xue, Daniela Clerici, Sara Mastaglio, Maria Teresa Lupo Stanghellini, Marco Ripa, Consuelo Corti, Jacopo Peccatori, Massimo Puoti, Massimo Bernardi, Antonella Castagna, Fabio Ciceri, Raffaella Greco, Chiara Oltolini   +19 more
doaj   +3 more sources

The Antifungal Pipeline: Fosmanogepix, Ibrexafungerp, Olorofim, Opelconazole, and Rezafungin [PDF]

Drugs, 2021
The epidemiology of invasive fungal infections is changing, with new populations at risk and the emergence of resistance caused by the selective pressure from increased usage of antifungal agents in prophylaxis, empiric therapy, and agriculture. Limited antifungal therapeutic options are further challenged by drug-drug interactions, toxicity, and ...
Martin Hoenigl, Rosanne Sprute, Matthias Egger, Amir Arastehfar, Oliver A. Cornely, Robert Krause, Cornelia Lass-Flörl, Juergen Prattes, Andrej Spec, George R. Thompson, Nathan Wiederhold, Jeffrey D. Jenks   +11 more
openaire   +4 more sources

P-1238. Assessment of Body Weight upon PK of Olorofim in Patients with Invasive Mould Infections [PDF]

Open Forum Infectious Diseases
Abstract Background Olorofim (OLO) is a novel antifungal active vs. Aspergillus (including azole-resistant strains), resistant moulds (e.g., Lomentospora prolificans [LoPro]), and dimorphic moulds. Potential impact of bodyweight upon systemic exposure was explored using pharmacokinetic (PK) data from ...
Cornelissen, Karen, Rex, John H, Zinzi, Daniela, Galbraith, Hal, Burt, Howard   +4 more
openaire   +2 more sources

Invasive Pulmonary Aspergillosis in Non-Neutropenic Patients: An Evolving Clinical Paradigm [PDF]

Diagnostics
Invasive pulmonary aspergillosis (IPA), traditionally associated with severe immunosuppression and neutropenia, is increasingly reported among non-neutropenic patients.
Rocco Morena, Helen Linda Morrone, Francesca Serapide, Alessandro Russo   +3 more
doaj   +2 more sources

Olorofim is potent against Madurella mycetomatis – the most common causative agent of Eumycetoma [PDF]

International Journal of Infectious Diseases, 2020
W. Lim, K. Eadie, B. Rijnders, A. Fahal, J. Oliver, M. Birch, W. van de Sande   +6 more
doaj   +2 more sources

An update on the development of novel antifungal agents for eumycetoma [PDF]

, 2023
Eumycetoma, a chronic subcutaneous mycosis, responds poorly to the available antifungal treatments and patients often require extensive surgical resection or amputation of the affected limb. More effective treatments are needed for eumycetoma.
Bonifaz, Alexandro, Chandler, David, van de Sande, Wendy   +2 more
core   +2 more sources

Lomentospora prolificans osteomyelitis and septic arthritis in an immunocompromised patient, requiring transhumeral amputation and use of the novel antifungal olorofim [PDF]

JSES Reviews, Reports, and Techniques
DrBSc, Hons, MD Thomas G O'Donnell, MD, DrBA, BSc, MD, FRACP Aleece MacPhail, MD, DrMBBS, FRACS, Ms Michael Blaser, MD, Aideanna Seenarain, BSc, Hons, DrPhD Sarah E. Kidd, BSc, Hons, DrPhD Catriona L. Halliday, BSc, Hons, DrMBBS, FRACP Zaal Meher-Homji, BSc, Hons, Ton Tran, MBBS, FRACS   +7 more
doaj   +2 more sources

The fungal expel of 5-fluorocytosine derived fluoropyrimidines mitigates its antifungal activity and generates a cytotoxic environment [PDF]

, 2022
Invasive aspergillosis remains one of the most devastating fungal diseases and is predominantly linked to infections caused by the opportunistic human mold pathogen Aspergillus fumigatus.
Alcazar-Fuoli, Laura, Baldin, Clara, Dallemulle, Alex, Gsaller, Fabio, Kühbacher, Alexander, Müller, Christoph, Niedrig, Anna, Sastré-Velásquez, Luis Enrique   +7 more
core   +1 more source

Antifungal resistance, combinations and pipeline: oh my!

Drugs in Context, 2023
Invasive fungal infections are a strong contributor to healthcare costs, morbidity and mortality, especially amongst hospitalized patients. Historically, Candida was responsible for approximately 15% of all nosocomial bloodstream infections.
Kayla R Stover, Brandon K Hawkins, J Myles Keck, Katie E Barber, David A Cretella   +4 more
doaj   +1 more source

Diagnosis and Treatment of Invasive Aspergillosis Caused by Non-fumigatus Aspergillus spp. [PDF]

, 2023
With increasing frequency, clinical and laboratory-based mycologists are consulted on invasive fungal diseases caused by rare fungal species. This review aims to give an overview of the management of invasive aspergillosis (IA) caused by non-fumigatus ...
Ackermann, Katharina, Cornely, Oliver Andreas, Koehler, Philipp, Lass-Flörl, Cornelia, Rath, Peter-Michael, Simon, Michaela, Steinmann, Jörg, Stemler, Jannik, Többen, Christina   +8 more
core   +1 more source