Results 21 to 30 of about 895 (178)

Redo bilateral lung transplantation in a previous heart-lung transplant recipient for invasive pulmonary scedosporiosis [PDF]

JHLT Open
Redo-bilateral lung transplant in previous heart-lung transplant is a rare operation. We describe our surgical and medical management experience with a heart-lung transplant recipient who developed chronic lung allograft dysfunction and invasive ...
Akshay Chauhan, MBBS, Nischal Ranganath, MD, PhD, John P. Scott, MD, Paschalis Vergidis, MD, Anja C. Roden, MD, Philip J. Spencer, MD, Mauricio A. Villavicencio, MD, Richard C. Daly, MD, Sahar A. Saddoughi, MD, PhD   +8 more
doaj   +2 more sources

A case of Lomentospora prolificans endophthalmitis treated with the novel antifungal agent Olorofim

Journal of Ophthalmic Inflammation and Infection
Purpose To report a case of endogenous Lomentospora prolificans endophthalmitis treated with the novel antifungal agent Olorofim. Case report A 57-year-old man developed disseminated Lomentospora prolificans with right endophthalmitis on the background ...
Michael Dong, Fiona Pearce, Nandini Singh, Ming-Lee Lin   +3 more
doaj   +3 more sources

Molecular Mechanism Underlying Resistance Variation to the Novel Agrochemical Quinofumelin in Fusarium graminearum [PDF]

Molecular Plant Pathology, Volume 27, Issue 4, April 2026.
The D155T, V179E, V179D and N281A mutations in FgDHODHII altered the binding mode of quinofumelin, resulting in diminished affinity and a negative correlation between binding affinity and the resistance level of these mutants. ABSTRACT Quinofumelin, a quinoline‐based fungicide, demonstrated potent antifungal activity against Fusarium graminearum, the ...
Xiaoru Yin, Xinlong Gao, Xudong Liu, Ziyang Zhang, Qian Xiu, Fuhao Ren, Jie Zhang, Mingguo Zhou, Yabing Duan   +8 more
wiley   +2 more sources

EUCAST olorofim MICs for 3,550 Danish mold and dermatophyte isolates from 2020 to 2023 [PDF]

Antimicrobial Agents and Chemotherapy
ABSTRACT The dihydroorotate dehydrogenase (DHODH) inhibitor olorofim has potent activity against most molds. Recent reports of in vitro acquired resistance to olorofim and an agrochemical fungicide DHODH inhibitor warrant continuous monitoring of in vitro
Joseph Meletiadis, Karin Meinike Jørgensen, Karen Marie Thyssen Astvad, Nissrine Abou-Chakra, Maiken Cavling Arendrup   +4 more
openaire   +3 more sources

Invasive Trichoderma longibrachiatum breakthrough infection in a hematology patient [PDF]

Medical Mycology Case Reports
Trichoderma species are emerging as pathogens, causing invasive fungal infections, particularly in immunocompromised individuals. We report the case of a 61-year-old neutropenic female with hepatosplenic T-cell lymphoma and profound neutropenia, who ...
Yuri Vanbiervliet, Robina Aerts, Ellen Boon, Toine Mercier, Ann-Sophie Jacob, Marijke Peetermans, Koen Debackere, Katrien Lagrou, Johan Maertens   +8 more
doaj   +2 more sources

New and Investigational Treatment Options for Dermatomycosis in the Era of Antifungal Resistance [PDF]

Journal of Fungi
Superficial mycoses (dermatomycoses) are a growing healthcare concern due to antifungal resistance, particularly among aging and immunocompromised populations.
Aditya K. Gupta, Amanda Liddy, Tong Wang
doaj   +2 more sources

P-1239. Systemic Exposure of Olorofim in Children with Invasive Fungal Infections [PDF]

Open Forum Infectious Diseases
Abstract Background Olorofim (OLO) is a novel antifungal active vs. Aspergillus (including azole-resistant strains), resistant moulds (e.g., Lomentospora prolificans [LoPro]), and dimorphic moulds.
Cornelissen, Karen, Rex, John H, Zinzi, Daniela, Bruggemann, Roger, Wright, James   +4 more
openaire   +2 more sources

The Silent Pandemic: Antifungal Resistance and the Future of Invasive Fungal Disease Management [PDF]

Microorganisms
Invasive fungal diseases (IFDs) represent an escalating global health threat, compounded by the rapid emergence of antifungal resistance (AFR). This review synthesizes the contemporary landscape of AFR from clinical and microbiological perspectives ...
Ruchika Bagga, Kumudhavalli Kavanoor Sridhar   +1 more
doaj   +2 more sources

95. Novel Antifungal Olorofim Use in Intractable CNS and Non-CNS Disseminated Coccidioidomycosis [PDF]

Open Forum Infectious Diseases
Abstract Background Disseminated coccidioidomycosis (DCM) requires long courses of antifungal treatment. Olorofim, a novel antifungal in development, selectively blocks pyrimidine biosynthesis by inhibiting fungal dihydroorotate dehydrogenase (DHODH), and we evaluated its impact on clinical and ...
Donovan, Fariba, Thompson, George R, Johnson, Royce H, Kuran, Rasha, Patterson, Thomas F, Hoenigl, Martin, Schaenman, Joanna M, Shoham, Shmuel, Holland, Steven M, Sikka, Monica K, Spec, Andrej, Bresnik, Mark, Galgiani, John N, Rex, John H   +13 more
openaire   +2 more sources

P-1098. Clinical outcomes in four patients with refractory Coccidioidal meningitis treated with olorofim [PDF]

Open Forum Infectious Diseases
Abstract Background Coccidioidal meningitis (CM) remains a highly morbid condition. Olorofim is a novel agent that inhibits the fungal dihydroorotate dehydrogenase enzyme and has potent in vitro activity against Coccidioidomycosis.
Yousefzadeh, Michelle, Goodman-Meza, David, Allyn, Paul R   +2 more
openaire   +2 more sources