Results 41 to 50 of about 895 (178)

Pharmacodynamics, Mechanisms of Action and Resistance, and Spectrum of Activity of New Antifungal Agents

Journal of Fungi, 2022
Several new antifungals are currently in late-stage development, including those with novel pharmacodynamics/mechanisms of action that represent new antifungal classes (manogepix, olorofim, ATI-2307, GR-2397). Others include new agents within established
Nathan P. Wiederhold
doaj   +1 more source

Novel Antifungals and Aspergillus Section Terrei with Potpourri Susceptibility Profiles to Conventional Antifungals

Journal of Fungi, 2023
The epidemiology of invasive fungal infections (IFIs) is currently changing, driven by aggressive immunosuppressive therapy, leading to an expanded spectrum of patients at risk of IFIs.
Roya Vahedi-Shahandashti, Jos Houbraken, Mike Birch, Cornelia Lass-Flörl   +3 more
doaj   +1 more source

Increasing Terbinafine Resistance in Danish Trichophyton Isolates 2019–2020 [PDF]

, 2022
Terbinafine resistance in Trichophyton species has emerged and appears to be increasing. A new EUCAST susceptibility testing method and tentative ECOFFs were recently proposed for Trichophyton.
Arendrup, Maiken Cavling, Astvad, Karen Marie Thyssen, Hare, Rasmus Krøger, Jørgensen, Karin Meinike, Saunte, Ditte Marie Lindhardt, Thomsen, Philip Kjettinge   +5 more
core   +2 more sources

Invasive pulmonary aspergillosis in the intensive care unit: current challenges and best practices

APMIS, Volume 131, Issue 11, Page 654-667, November 2023., 2023
The prevalence of invasive pulmonary aspergillosis (IPA) is growing in critically ill patients in the intensive care unit (ICU). It is increasingly recognized in immunocompetent hosts and immunocompromised ones. IPA frequently complicates both severe influenza and severe coronavirus disease 2019 (COVID‐19) infection.
Sarah Gaffney, Dearbhla M. Kelly, Puteri Maisarah Rameli, Eoin Kelleher, Ignacio Martin‐Loeches   +4 more
wiley   +1 more source

Antifungal metabolites, their novel sources, and targets to combat drug resistance [PDF]

, 2022
Excessive antibiotic prescriptions as well as their misuse in agriculture are the main causes of antimicrobial resistance which poses a growing threat to public health. It necessitates the search for novel chemicals to combat drug resistance.
Choudhary, Megha, Gupta, Sanjay, Kumar, Vijay, Kumar, Vivek, Naik, Bindu, Saris, Per Erik Joakim, Verma, Ankit   +6 more
core   +1 more source

Scedosporium species and Lomentospora prolificans fungaemia is uniformly fatal in patients with haematological malignancy

Internal Medicine Journal, Volume 53, Issue 8, Page 1489-1491, August 2023., 2023
Abstract Scedosporium and Lomentospora species are environmental moulds that are virulent in immunocompromised hosts and rarely cause bloodstream infection (BSI). Patients with Scedosporium and Lomentospora species BSI were identified by the state public laboratory service in Queensland, Australia, over a 20‐year period.
Adam G. Stewart, Claire Heney, David L. Paterson, Patrick N. A. Harris, Felicity Edwards, Kevin B. Laupland   +5 more
wiley   +1 more source

Invasive aspergillosis in liver transplant recipients

Transplant Infectious Disease, Volume 25, Issue 3, June 2023., 2023
Abbreviations: Ciclos, cyclosporine; CNS, central nervous system; IA, invasive aspergillosis; ICU, intensive care unit; IS, immunosuppression; MELD, model for end‐stage liver disease; RBC, red blood cell; Tac, tacrolimus. aMultivariate analysis. *For invasive fungal infection. **For solid organ transplant.
Cléa Melenotte, Vishukumar Aimanianda, Monica Slavin, José María Aguado, Darius Armstrong‐James, Yee‐Chun Chen, Shahid Husain, Christian Van Delden, Faouzi Saliba, Agnès Lefort, Francoise Botterel, Olivier Lortholary   +11 more
wiley   +1 more source

Novel antifungal agents in clinical trials [version 2; peer review: 2 approved]

F1000Research, 2022
Invasive fungal diseases due to resistant yeasts and molds are an important and increasing public health threat, likely due to a growing population of immunosuppressed hosts, increases in antifungal resistance, and improvements in laboratory diagnostics.
Samantha E. Jacobs, Panagiotis Zagaliotis, Thomas J. Walsh   +2 more
doaj   +1 more source

WITHDRAWN: Reversing olorofim activity reveals multifactorial drug tolerance in Aspergillus fumigatus

, 2023
Withdrawal StatementThe authors have withdrawn their manuscript owing to finding new evidence contradictory to the results and conclusions presented in this work. Therefore, the authors do not wish this work to be cited as reference for the project. If you have any questions, please contact the corresponding author.
Clara Valero, Myles Mcmanus, Ashva Ram Anna Durai, James Tindale, Sara Gago, Michael J Bromley   +5 more
openaire   +1 more source

Prognostic factors in 264 adults with invasive Scedosporium spp. and Lomentospora prolificans infection reported in the literature and FungiScope [PDF]

, 2019
Invasive Scedosporium spp. and Lomentospora prolificans infections are an emerging threat in immunocompromised and occasionally in healthy hosts. Scedosporium spp. is intrinsically resistant to most, L. prolificans to all the antifungal drugs currently
Aurbach U., Caggiano G., Chander J., Chedotal I., Cheng M. P., Cornely O. A., Denis J., Duarte R. F., Duran Graeff L., Hamprecht A., Herbrecht R., Kohler P., Lackner M., Los-Arcos I., Mares M., Meissner A., Mellinghoff S., Montagna M. T., Pakstis D. L., Piepenbrock E., Salmanton-Garcia J., Seidel D., Slavin M., Stecher M., Trauth J., Vehreschild J. J., Vehreschild M. J. G. T., Wisplinghoff H.   +27 more
core   +3 more sources