Results 41 to 50 of about 731,369 (326)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Search for the X(1812) in $B^{\pm} \to K^{\pm} \omega \phi$

, 2009
We report on a search for the X(1812) state in the decay $B^{\pm} \to K^{\pm} \omega \phi$ with a data sample of $657\times10^6$ $B\bar{B}$ pairs collected with the Belle detector at the KEKB $e^+e^-$ collider. No significant signal is observed. An upper
Adachi, I., Aihara, H., Arinstein, K., Aushev, T., Bakich, A., Barberio, E., Bay, A., Bhardwaj, V., Bozek, A., Bračko, M., Browder, T., Chang, M.-C., Chen, A., Cheon, B., Cho, I.-S., Choi, Y., Dalseno, J., Drutskoy, A., Dungel, W., Eidelman, S., Gabyshev, N., Goldenzweig, P., Ha, H., Haba, J., Han, B.-Y., Hayasaka, K., Hazumi, M., Hoshi, Y., Hyun, H., Inami, K., Ishikawa, A., Itoh, R., Iwasaki, M., Iwasaki, Y., Kah, D., Kang, J., Kapusta, P., Katayama, N., Kawasaki, T., Kim, H., Kim, Y., Kim, Y., Ko, B., Korpar, S., Križan, P., Krokovny, P., Kyeong, S.-H., Lange, J., Lee, M., Lee, S., Lesiak, T., Li, J., Limosani, A., Liu, C., Liu, Y., Liventsev, D., Louvot, R., Matyja, A., Mconie, S., Miyata, H., Miyazaki, Y., Mizuk, R., Nagasaka, Y., Nakano, E., Nakao, M., Nakazawa, H., Natkaniec, Z., Nishida, S., Nishimura, K., Nitoh, O., Ogawa, S., Ohshima, T., Okuno, S., Ozaki, H., Pakhlov, P., Pakhlova, G., Park, C., Park, H., Park, H., Park, K., Pestotnik, R., Piilonen, L., Sahoo, H., Sakai, K., Sakai, Y., Schneider, O., Schümann, J., Seidl, R., Sekiya, A., Senyo, K., Sevior, M., Shapkin, M., Shen, C., Shiu, J.-G., Shwartz, B., Sokolov, A., Stanič, S., Starič, M., Sumiyoshi, T., Tanaka, M., Taylor, G., Teramoto, Y., Uehara, S., Uglov, T., Unno, Y., Uno, S., Usov, Y., Varner, G., Varvell, K., Vervink, K., Wang, C., Wang, C., Wang, P., Wang, X., Watanabe, Y., Wedd, R., Won, E., Yabsley, B., Yamashita, Y., Yamauchi, M., Yuan, C., Zhang, C., Zhang, Z., Zivko, T., Zupanc, A., Zyukova, O.   +125 more
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Genetically Predicted Circulating Omega-3 Fatty Acids Levels Are Causally Associated With Increased Risk for Systemic Lupus Erythematosus

Frontiers in Nutrition, 2022
BackgroundAccumulating evidence has demonstrated the associations of omega-3 or omega-6 polyunsaturated fatty acids (PUFAs) with the disease activity and inflammatory mediators of systemic lupus erythematosus (SLE), but the evidence of causal links of ...
Peng Wang, Peng Wang, Kun Xiang, Kun Xiang, Yuan-Yuan Xu, Yi-Sheng He, Yi-Sheng He, Yu-Qian Hu, Yu-Qian Hu, Jing Ni, Jing Ni, Hai-Feng Pan, Hai-Feng Pan   +12 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Cardioprotective Effects of Omega-3 Polyunsaturated Fatty Acids: Dichotomy between Experimental and Clinical Studies

Marine Drugs, 2018
The high-fat diet of North Americans has a major impact on cardiovascular disease occurrence. Notably, fatty acids have been identified as important factors that could modulate such diseases, especially myocardial infarction (MI). Experimentally, omega-3
Melissa Desnoyers, Kim Gilbert, Guy Rousseau   +2 more
doaj   +1 more source

Omega-6 fatty acids and inflammation [PDF]

Prostaglandins, Leukotrienes and Essential Fatty Acids, 2018
Inflammation is a normal process that is part of host defence and tissue healing. However, excessive or unresolved inflammation can lead to uncontrolled tissue damage, pathology and disease. In humans on a Western diet, the omega-6 polyunsaturated fatty acid arachidonic acid (ARA) makes a significant contribution to the fatty acids present in the ...
Jacqueline K, Innes, Philip C, Calder
openaire   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Cociente omega-6/omega-3 y cognición en niños con epilepsia

Anales de Pediatría, 2019
Resumen: Introducción: El deterioro cognitivo es una consecuencia común de la epilepsia en niños. El objetivo del estudio fue evaluar el cociente de los niveles de ácidos grasos omega-6 y omega-3 y su impacto en el funcionamiento cognitivo de niños con ...
Karima Abdelfattah Bahagat, Marwa Elhady, Ali Abdel Aziz, Eman R. Youness, Elzarif Zakzok   +4 more
doaj   +1 more source

Sustainable bioplastics manufacturing from renewable sources

FEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto, Marika Avitabile, Michela Famiglietti, Talayeh Kordjazi, Marzieh Moosavi‐Nasab, Odile F. Restaino, Loredana Mariniello   +6 more
wiley   +1 more source