Omeprazole exacerbates intervertebral disc degeneration through Caspase-3 mediated apoptosis of nucleus pulposus cells: a Mendelian randomization, network toxicology, and in vitro experimental study [PDF]
Journal of Orthopaedic Surgery and ResearchObjective To investigate the causal correlation and toxicological mechanisms of omeprazole in intervertebral disc degeneration (IVDD), alongside a particular emphasis on Caspase-3 (CASP3) mediated apoptosis of nucleus pulposus cells (NPCs).
Yuchao Jia +3 more
doaj +2 more sources
Impact of fresh grape juice on the pharmacokinetics of omeprazole: results of a food–drug interaction study [PDF]
Frontiers in PharmacologyGrapes have been widely used for dietary ailments due to their attributed pharmacological activities. Resveratrol, the chief constituent of grapes, is responsible for their pharmacological benefits.
Tayyaba Iftikhar +12 more
doaj +2 more sources
Acid-Neutralizing Omeprazole Formulation for Rapid Release and Absorption [PDF]
PharmaceuticsBackground/Objectives: Omeprazole undergoes degradation in acidic conditions, which makes it unstable in low pHs found in the gastric environment. The vast majority of already marketed omeprazole formulations use enteric polymer coatings to protect the ...
Sreela Ramesh +6 more
doaj +2 more sources
Omeprazole Minimally Alters the Fecal Microbial Community in Six Cats: A Pilot Study
Frontiers in Veterinary Science, 2018 Although they have historically been thought of as safe medications, proton pump inhibitors such as omeprazole have been associated with an increased risk of enteric, particularly Clostridium difficile, infections in people.
Jan S Suchodolski, M Katherine Tolbert
exaly +3 more sources
Alimentary Pharmacology & Therapeutics, 1991 SUMMARYOmeprazole is a potent and effective antisecretory drug. Benefits in gastric and duodenal ulceration nevertheless seem marginal because standard treatments are very effective. More obvious advantages are discernible in oesophageal reflux disease where more profound acid inhibition may be needed to obtain symptom relief.
John A. Oates +2 more
+9 more sources
Clinical and Translational Science, 2022 This study evaluated the effect of repeated doses of elagolix on the pharmacokinetics (PK) of omeprazole and its metabolites in healthy premenopausal female subjects. Adult premenopausal female subjects (N = 20) received a single oral dose of omeprazole (
Ahmed Nader +3 more
doaj +1 more source
Omeprazole and adenocarcinoma in the stomach of rats submitted to duodenogastric reflux. Is there a protective effect? [PDF]
Acta Cirúrgica Brasileira, 2020 Purpose: To investigate the role of omeprazole and nitrites on the gastric mucosa of rats submitted to specific techniques to induce duodenogastric reflux.
Rosângela Lucinda Rocha Monteiro +4 more
doaj +1 more source
Omeprazole and lansoprazole enantiomers induce CYP3A4 in human hepatocytes and cell lines via glucocorticoid receptor and pregnane X receptor axis. [PDF]
PLoS ONE, 2014 Benzimidazole drugs lansoprazole and omeprazole are used for treatment of various gastrointestinal pathologies. Both compounds cause drug-drug interactions because they activate aryl hydrocarbon receptor and induce CYP1A genes.
Aneta Novotna, Zdenek Dvorak
doaj +1 more source
Omeprazole inhibits proliferation and modulates autophagy in pancreatic cancer cells. [PDF]
PLoS ONE, 2011 BACKGROUND: Omeprazole has recently been described as a modulator of tumour chemoresistance, although its underlying molecular mechanisms remain controversial. Since pancreatic tumours are highly chemoresistant, a logical step would be to investigate the
Andrej Udelnow +9 more
doaj +1 more source
Enhanced Characterization of Drug Metabolism and the Influence of the Intestinal Microbiome: A Pharmacokinetic, Microbiome, and Untargeted Metabolomics Study. [PDF]
, 2020 Determining factors that contribute to interindividual and intra-individual variability in pharmacokinetics (PKs) and drug metabolism is essential for the optimal use of drugs in humans.
Alhaja, Maher +8 more
core +1 more source