Results 1 to 10 of about 73,909 (338)

Molecular mechanism of inhibition of the mitochondrial carnitine/acylcarnitine transporter by omeprazole revealed by proteoliposome assay, mutagenesis and bioinformatics. [PDF]

PLoS ONE, 2013
The effect of omeprazole on the mitochondrial carnitine/acylcarnitine transporter has been studied in proteoliposomes. Externally added omeprazole inhibited the carnitine/carnitine antiport catalysed by the transporter.
Annamaria Tonazzi, Ivano Eberini, Cesare Indiveri   +2 more
doaj   +1 more source

Efficacy of transoral fundoplication vs omeprazole for treatment of regurgitation in a randomized controlled trial.

Gastroenterology, 2015
BACKGROUND & AIMS Transoral esophagogastric fundoplication (TF) can decrease or eliminate features of gastroesophageal reflux disease (GERD) in some patients whose symptoms persist despite proton pump inhibitor (PPI) therapy.
J. Hunter, P. Kahrilas, R. Bell, Erik B. Wilson, K. Trad, J. P. Dolan, K. Perry, B. Oelschlager, N. Soper, Brad E. Snyder, M. Burch, W. Melvin, K. Reavis, Daniel Turgeon, Eric S. Hungness, B. Diggs   +15 more
semanticscholar   +1 more source

Recent advances: rheumatology [PDF]

, 2000
No abstract ...
Madhok, R., Kerr, H., Capell, H.A.
core   +4 more sources

In vivo and in vitro protective effects of omeprazole against neuropathic pain

Scientific Reports, 2016
Apart from reducing the acid secretion, omeprazole inhibits activation of the nuclear factor-κB, release of inflammatory cytokines and chemotaxis of neutrophils. These mechanisms prompted us to evaluate antineuropathic effect of omeprazole in the chronic
Sanjay K. Chanchal, U. Mahajan, S. Siddharth, N. Reddy, S. Goyal, P. Patil, B. Bommanahalli, C. Kundu, Chandragouda R. Patil, S. Ojha   +9 more
semanticscholar   +1 more source

The association of increased stomach wall radiotracer uptake with prolonged use of Omeprazole capsules on myocardial perfusion imaging (MPI) using 99mTc-sestamibi SPECT [PDF]

, 2013
Myocardial perfusion imaging (MPI) is widely used in routine practice for diagnosis and risk stratification of coronary artery disease (CAD). Intense curvilinear activity in the stomach wall of a patient was seen on MPI raw data.
Abbaszadeh, M., Assadi, M., Jallalat, S., Javadi, H., Mogharrabi, M., Nabipour, I., Semnani, S., Tabib, S.M.   +7 more
core   +1 more source

Effects of CYP2C19 Genetic Polymorphisms on PK/PD Responses of Omeprazole in Korean Healthy Volunteers

Journal of Korean medical science, 2017
The aim of this study was to examine the effects of CYP2C19*2 and *3 genetic polymorphisms on omeprazole pharmacokinetic (PK) and pharmacodynamic (PD) responses.
Sunny Park, Y. Hyun, Y. Kim, J. H. Lee, S. Ryu, Jeong Mi Kim, W. Oh, H. Na, Jong Gu Lee, D. Seo, I. Y. Hwang, Z. Park, I. Jang, Jaeseong Oh, S. Choi   +14 more
semanticscholar   +1 more source

Changes in omeprazole pharmacokinetics in rats with diabetes induced by alloxan or streptozotocin: Faster clearance of omeprazole due to induction of hepatic CYP1A2 and 3A1

Journal of Pharmacy & Pharmaceutical Sciences, 2007
Purpose. To investigate the effect of diabetes mellitus induced by alloxan (DMIA) or streptozotocin (DMIS) on the pharmacokinetics of omeprazole in rats.
Dae Young Lee, Myung G. Lee, Hyun Sook Shin, Inchul Lee   +3 more
doaj   +1 more source

A Prospective, Placebo‐Controlled Pilot Evaluation of the Effect of Omeprazole on Serum Calcium, Magnesium, Cobalamin, Gastrin Concentrations, and Bone in Cats

Journal of Veterinary Internal Medicine, 2016
Background Chronic proton pump inhibitor administration has been associated with electrolyte and cobalamin deficiency, disrupted bone homeostasis, hypergastrinemia, and rebound acid hypersecretion in humans.
E. Gould, C. Clements, A. Reed, L. Giori, J. Steiner, J. Lidbury, J. Suchodolski, M. Brand, T. Moyers, L. Emery, M. Tolbert   +10 more
semanticscholar   +1 more source

Binding of omeprazole to protein targets identified by monoclonal antibodies.

PLoS ONE, 2020
Omeprazole is the most commonly used proton pump inhibitor (PPI), a class of medications whose therapeutic mechanism of action involves formation of a disulfide linkage to cysteine residues in the H+/K+ ATPase pump on gastric secretory cells.
Naw May Pearl Cartee, Michael M Wang
doaj   +2 more sources

Impact of fresh grape juice on the pharmacokinetics of omeprazole: results of a food–drug interaction study

Frontiers in Pharmacology
Grapes have been widely used for dietary ailments due to their attributed pharmacological activities. Resveratrol, the chief constituent of grapes, is responsible for their pharmacological benefits.
Tayyaba Iftikhar, Zafar Iqbal, Yasar Shah, Nauman Rahim Khan, Muhammad Abbas, Omer Shehzad, Fazal Hadi, Haseeba Sardar, Ali Abusharha, Maria Daglia, Maria Daglia, Haroon Khan, Haroon Khan   +12 more
doaj   +1 more source