Results 91 to 100 of about 109,057 (295)

Enabling precision medicine in neonatology, an integrated repository for preterm birth research [PDF]

, 2018
Preterm birth, or the delivery of an infant prior to 37 weeks of gestation, is a significant cause of infant morbidity and mortality. In the last decade, the advent and continued development of molecular profiling technologies has enabled researchers to ...
Chubiz, Jessica, England, Sarah K., Macones, George   +2 more
core   +5 more sources

Multi-omics decodes host-specific and environmental microbiome interactions in sepsis

Frontiers in Microbiology
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, and its pathogenesis involves complex interactions between the host and the microbiome.
Jiamin Lu, Jiamin Lu, Wen Zhang, Wen Zhang, Yuzhou He, Mei Jiang, Zhankui Liu, Jirong Zhang, Jirong Zhang, Lanzhi Zheng, Bingzhi Zhou, Jielian Luo, Jielian Luo, Chenming He, Chenming He, Yunan Shan, Runze Zhang, Runze Zhang, KaiLiang Fan, Bangjiang Fang, Bangjiang Fang, Chuanqi Wan, Chuanqi Wan   +22 more
doaj   +1 more source

moSCminer: a cell subtype classification framework based on the attention neural network integrating the single-cell multi-omics dataset on the cloud [PDF]

PeerJ
Single-cell omics sequencing has rapidly advanced, enabling the quantification of diverse omics profiles at a single-cell resolution. To facilitate comprehensive biological insights, such as cellular differentiation trajectories, precise annotation of ...
Joung Min Choi, Chaelin Park, Heejoon Chae   +2 more
doaj   +2 more sources

Integrating Emerging Areas of Nursing Science into PhD Programs [PDF]

, 2015
The Council for the Advancement of Nursing Science aims to “facilitate and recognize life-long nursing science career development” as an important part of its mission.
Conley, Yvette P., Dunbar-Jacob, Jacqueline, Heitkemper, Margaret M., Henly, Susan J., McCarthy, Ann Marie, McCarthy, Donna O., Moore, Shirley M., Redeker, Nancy S., Stone, Patricia W., Titler, Marita, Wyman, Jean F.   +10 more
core   +1 more source

Integrative Omics for Interactomes

, 2018
Single-layer omics provide limited insight, whereas integrated multi-omics layers allow understanding of their combined influence on the complex biological process. The integrative omics approach has been initially applied to cancer research and later used in understanding host-pathogen interactions and pluripotency regulatory networks in stem cells ...
Debangana Chakravorty, Krishnendu Banerjee, Sudipto Saha   +2 more
openaire   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Development of a Prediction Model for Progression Risk in High‐Grade Gliomas Based on Habitat Radiomics and Pathomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the value of constructing models based on habitat radiomics and pathomics for predicting the risk of progression in high‐grade gliomas. Methods This study conducted a retrospective analysis of preoperative magnetic resonance (MR) images and pathological sections from 72 patients diagnosed with high‐grade gliomas (52 ...
Yuchen Zhu, Yuxi Gong, Weilin Xu, Xingjian Sun, Gefei Jiang, Lei Qiu, Kexin Shi, Mengxing Wu, Yinjiao Fei, Jinling Yuan, Jinyan Luo, Yurong Li, Yuandong Cao, Minhong Pan, Shu Zhou   +14 more
wiley   +1 more source

scCross: a deep generative model for unifying single-cell multi-omics with seamless integration, cross-modal generation, and in silico exploration

Genome Biology
Single-cell multi-omics data reveal complex cellular states, providing significant insights into cellular dynamics and disease. Yet, integration of multi-omics data presents challenges.
Xiuhui Yang, Koren K. Mann, Hao Wu, Jun Ding   +3 more
doaj   +1 more source

Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy

Advanced Functional Materials, EarlyView.
FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao, Yejing Zhu, Hengchao Yu, Jun Zhu, Bo Wang, Yu Qiao, Zhimin Tian, Junlong Zhao, Lei Liu   +8 more
wiley   +1 more source

Laser‐Microscribed Glass Enables Surface‐Microfluidics‐Facilitated, Affordable, Rapid Cancer Diagnosis

Advanced Functional Materials, EarlyView.
A transparent, laser‐microscribed glass platform enables cancer diagnosis within 1 h—much faster than histology, which takes days, and free from the chemical or contrast risks of MRI or CT scans. The antibody‐functionalized rough glass surface captures viable cancer cells directly from suspension, allowing instant optical readout and offering a rapid ...
Anish Pal, Snehasis Mishra, Arani Mukhopadhyay, Ilias Papailias, Atique U. Ahmed, Constantine M. Megaridis   +5 more
wiley   +1 more source