Integrative Multi-Omics in Biomedical Research [PDF]
Biomolecules, 2021 Genome technologies have revolutionized biomedicine, but the complexity of biological systems cannot be explained by genomics alone [...]
Hill, Michelle M., Gerner, Christopher
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Multi-omics integration accurately predicts cellular state in unexplored conditions for Escherichia coli. [PDF]
, 2016 A significant obstacle in training predictive cell models is the lack of integrated data sources. We develop semi-supervised normalization pipelines and perform experimental characterization (growth, transcriptional, proteome) to create Ecomics, a ...
Kim, Minseung +3 more
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Multi-omics integration reveals molecular networks and regulators of psoriasis. [PDF]
, 2019 BackgroundPsoriasis is a complex multi-factorial disease, involving both genetic susceptibilities and environmental triggers. Genome-wide association studies (GWAS) and epigenome-wide association studies (EWAS) have been carried out to identify genetic ...
Arneson, Douglas +5 more
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Integrated Omics of Metastatic Colorectal Cancer [PDF]
Cancer Cell, 2020 We integrate the genomics, proteomics, and phosphoproteomics of 480 clinical tissues from 146 patients in a Chinese colorectal cancer (CRC) cohort, among which 70 had metastatic CRC (mCRC). Proteomic profiling differentiates three CRC subtypes characterized by distinct clinical prognosis and molecular signatures.
Chen Li +21 more
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Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis [PDF]
, 2017 IgA nephropathy (IgAN) is the most prevalent among primary glomerular diseases worldwide. Although our understanding of IgAN has advanced significantly, its underlying biology and potential drug targets are still unexplored.
Cisek, Katryna +11 more
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Machine Learning and Integrative Analysis of Biomedical Big Data. [PDF]
, 2019 Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome)
Choi, Howard +5 more
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Systems biology in inflammatory bowel diseases [PDF]
, 2014 Purpose of review: Ulcerative colitis (UC) and Crohn’s Disease (CD) are the two predominant types of inflammatory bowel disease (IBD), affecting over 1.4 million individuals in the US.
Iliopoulos, D, Koukos, G, Polytarchou, C
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MSPL: Multimodal Self-Paced Learning for Multi-Omics Feature Selection and Data Integration
IEEE Access, 2019 Rapid advances in high-throughput sequencing technology have led to the generation of a large number of multi-omics biological datasets. Integrating data from different omics provides an unprecedented opportunity to gain insight into disease mechanisms ...
Zi-Yi Yang +3 more
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Computational Models for Transplant Biomarker Discovery. [PDF]
, 2015 Translational medicine offers a rich promise for improved diagnostics and drug discovery for biomedical research in the field of transplantation, where continued unmet diagnostic and therapeutic needs persist.
Sarwal, Minnie M, Wang, Anyou
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Ten quick tips for avoiding pitfalls in multi-omics data integration analyses.
PLoS Computational Biology, 2023 Data are the most important elements of bioinformatics: Computational analysis of bioinformatics data, in fact, can help researchers infer new knowledge about biology, chemistry, biophysics, and sometimes even medicine, influencing treatments and ...
Davide Chicco +2 more
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