Results 81 to 90 of about 109,057 (295)
Statistical single cell multi-omics integration
Current Opinion in Systems Biology, 2018 Single cell high throughput genomic measurements are revolutionizing the fields of biology and medicine, providing a means to tackle biological problems that have thus far been inaccessible, such as the systematic discovery of new cell types, the identification of cellular heterogeneity in health and disease, or the cell-fate decisions taking place ...
Colomé-Tatché, M., Theis, F.J.
openaire +3 more sources
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso +4 more
wiley +1 more source
Editorial: Integration of omics into MRA
International Journal of Food Microbiology, 2018 International ...
Cocolin, Luca +2 more
openaire +5 more sources
Network-based multi-omics integrative analysis methods in drug discovery: a systematic review
BioData MiningThe integration of multi-omics data from diverse high-throughput technologies has revolutionized drug discovery. While various network-based methods have been developed to integrate multi-omics data, systematic evaluation and comparison of these methods ...
Wei Jiang +3 more
doaj +1 more source
Heterogeneity in pure microbial systems: experimental measurements and modeling [PDF]
, 2017 Cellular heterogeneity influences bioprocess performance in ways that until date are not completely elucidated. In order to account for this phenomenon in the design and operation of bioprocesses, reliable analytical and mathematical descriptions are ...
González-Cabaleiro, Rebeca +4 more
core +2 more sources
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
CEN‐tools: an integrative platform to identify the contexts of essential genes
Molecular Systems Biology, 2020 An emerging theme from large‐scale genetic screens that identify genes essential for cell fitness is that essentiality of a given gene is highly context‐specific.
Sumana Sharma +4 more
doaj +1 more source
Kronos: a workflow assembler for genome analytics and informatics. [PDF]
, 2017 BackgroundThe field of next-generation sequencing informatics has matured to a point where algorithmic advances in sequence alignment and individual feature detection methods have stabilized.
Aniba, Radhouane +9 more
core +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source