Results 61 to 70 of about 577 (167)

Is Pitolisant Effective in Reducing Excessive Daytime Sleepiness and Cataplexy in Adults with Narcolepsy? [PDF]

, 2019
Objective: The objective of this selective EBM review is to determine whether or not pitolisant is effective in reducing excessive daytime sleepiness and cataplexy in adults with narcolepsy.
Michael, Christina M
core   +1 more source

Sleep disorders in children [PDF]

, 2010
Although sleep disorders such as insomnia and obstructive sleep apnea are common in both children and adults, the clinical features and treatments for these conditions differ considerably between these two populations.
Hoban, Timothy F.
core   +1 more source

491 Efficacy of FT218, a Once-Nightly Sodium Oxybate Formulation, by Narcolepsy Subtype: A Post Hoc Analysis From the REST-ON Study

, 2021
FT218 is an investigational, once-nightly, controlled-release formulation of sodium oxybate for the treatment of narcolepsy. The purpose of this post hoc analysis of the REST-ON study was to evaluate the effect of FT218 on measures of excessive ...
A. Roy, A. Morse, J. Dubow, D. Seiden, R. Bogan   +4 more
semanticscholar   +1 more source

Daytime sleepiness and BMI exhibit gender and age differences in patients with central disorders of hypersomnolence

Journal of Sleep Research, Volume 34, Issue 3, June 2025.
In a cohort of central disorders of hypersomnolence, specifically women with idiopathic hypersomnia showed a marked subjective daytime sleepiness peak in the early 30s, while the body mass index only started to rise at that age. Better understanding of the pathophysiology of these gender and age‐specific characteristics will support tailored ...
Laura Ferrazzini, Markus Schmidt, Zhongxing Zhang, Ramin Khatami, Yves Dauvilliers, Lucie Barateau, Geert Mayer, Fabio Pizza, Giuseppe Plazzi, Jari K. Gool, Rolf Fronczek, Gert Jan Lammers, Rafael del Rio‐Villegas, Rosa Peraita‐Adrados, Markku Partinen, Sebastiaan Overeem, Karel Sonka, Joan Santamaria, Raphael Heinzer, Francesca Canellas, Antonio Martins da Silva, Birgit Högl, Christian Veauthier, Aleksandra Wierzbicka, Eva Feketeova, Jitka Buskova, Michel Lecendreux, Silvia Miano, Ulf Kallweit, Anna Heidbreder, Claudio L. A. Bassetti, Julia van der Meer   +31 more
wiley   +1 more source

Growth Hormone Deficiency and Excessive Sleepiness: A Case Report and Review of the Literature [PDF]

, 2019
The somatotropic axis is intricately involved in normal sleep, as evidenced by the fact that hypothalamic growth hormone-releasing hormone (GHRH) has sleep promoting effects and pituitary growth hormone (GH) release is strongly associated with slow-wave ...
Eugster, Erica, Gohil, Anisha
core   +1 more source

489 Pivotal Phase 3 Study of FT218, a Once-Nightly Sodium Oxybate Formulation, in Patients With Narcolepsy: REST-ON Primary Results

, 2021
Sodium oxybate (SO) is an effective treatment for patients with narcolepsy; however, currently available SO formulations require twice-nightly dosing.
C. Kushida, C. Shapiro, T. Roth, M. Thorpy, R. Rosenberg, Bruce C. Corser, A. Ajayi, J. Dubow, D. Seiden, Y. Dauvilliers   +9 more
semanticscholar   +1 more source

International Swiss Primary Hypersomnolence and Narcolepsy Cohort Study (iSPHYNCS): the impact of psychiatric comorbidities on daily life in central disorders of hypersomnolence—a vicious circle

Journal of Sleep Research, Volume 34, Issue 3, June 2025.
Summary Presence of psychiatric comorbidities is well documented in narcolepsy type‐1 (NT1) but there are limited data on patients with ‘other central disorders of hypersomnolence’ (OCH). This study aimed to investigate frequency of psychiatric comorbidities in patients with NT1 and OCH, and to evaluate their impact on quality of life and sleep as an ...
Merve Aktan Suzgun, Elena S. Wenz, Julia van der Meer, Livia G. Fregolente, Jan D. Warncke, Silvia Miano, Jens Acker, Mathias Strub, Elisabeth Olliges, Ramin Khatami, Markus H. Schmidt, iSPHYNCS Investigators, Claudio L. A. Bassetti, Sigrid von Manitius   +13 more
wiley   +1 more source

A Stage-Based Approach to Therapy in Parkinson’s Disease [PDF]

, 2019
Parkinson's disease (PD) is a neurodegenerative disorder that features progressive, disabling motor symptoms, such as bradykinesia, rigidity, and resting tremor.
Barbone, Filomena, Bonanni, Laura, Carrarini, Claudia, Di Pietro, Martina, Di Stefano, Vincenzo, Dono, Fedele, Ferri, Laura, Onofrj, Marco, Rispoli, Marianna G, Russo, Mirella, Sensi, Stefano Luca, Thomas, Astrid, Vitale, Michela   +12 more
core   +1 more source

492 Efficacy of FT218, a Once-Nightly Sodium Oxybate Formulation, by Stimulant Use: A Post Hoc Analysis From the REST-ON Study

, 2021
FT218 is an investigational, once-nightly, controlled-release formulation of sodium oxybate for the treatment of narcolepsy. The purpose of this post hoc analysis of the REST-ON study was to evaluate the effect of FT218 on measures of excessive ...
A. Roy, A. Morse, J. Dubow, D. Seiden, R. Bogan   +4 more
semanticscholar   +1 more source

The electroretinography to identify biomarkers of idiopathic hypersomnia and narcolepsy type 1

Journal of Sleep Research, Volume 34, Issue 1, February 2025.
Summary Hypersomnia spectrum disorders are underdiagnosed and poorly treated due to their heterogeneity and absence of biomarkers. The electroretinography has been proposed as a proxy of central dysfunction and has proved to be valuable to differentiate certain psychiatric disorders.
Héloïse Rach, Ulker Kilic‐Huck, Pierre A. Geoffroy, Tristan Bourcier, Sophie Braun, Henri Comtet, Elisabeth Ruppert, Laurence Hugueny, Marc Hebert, Eve Reynaud, Patrice Bourgin   +10 more
wiley   +1 more source