Nodding syndrome is unlikely to be an autoimmune reaction to leiomodin-1 after infection by Onchocerca volvulus [PDF]
Biochemistry and Biophysics Reports, 2023 Nodding syndrome is a neurological disease of children in northern Uganda. Infection with the nematode parasite Onchocerca volvulus has been epidemiologically implicated as the cause of the disease.
Kenneth G. Kodja +5 more
doaj +2 more sources
Onchocerca volvulus-specific antibody and cellular responses in onchocerciasis patients treated annually with ivermectin for 30 years and exposed to parasite transmission in central Togo [PDF]
PLoS Neglected Tropical Diseases, 2022 Background Annual mass drug administrations (MDA) of ivermectin will strongly reduce Onchocerca volvulus microfilariae (mf) in the skin and in the onchocerciasis patients’ eyes. Ivermectin treatment will also affect the expression of immunity in patients,
Saskia I. Johanns +10 more
doaj +3 more sources
Crystal structure of N-terminally hexahistidine-tagged Onchocerca volvulus macrophage migration inhibitory factor-1. [PDF]
Acta Crystallogr F Struct Biol CommunN‐terminally hexahistidine‐tagged O. volvulus macrophage migration inhibitory factor‐1 has a unique jellyfish‐like structure with the prototypical macrophage migration inhibitory factor trimer as the `head' and a C‐terminal extension as the `tail'.Onchocerca volvulus causes blindness, onchocerciasis, skin infections and devastating neurological ...
Kimble AD +10 more
europepmc +2 more sources
Adjuvanted Fusion Protein Vaccine Induces Durable Immunity to Onchocerca volvulus in Mice and Non-Human Primates [PDF]
Vaccines, 2023 Onchocerciasis remains a debilitating neglected tropical disease. Due to the many challenges of current control methods, an effective vaccine against the causative agent Onchocerca volvulus is urgently needed.
Nathan M. Ryan +17 more
doaj +2 more sources
A four-antigen mixture for rapid assessment of Onchocerca volvulus infection. [PDF]
PLoS Neglected Tropical Diseases, 2009 Onchocerciasis, an infection caused by the filarial nematode Onchocerca volvulus, is a major public health concern. Given the debilitating symptoms associated with onchocerciasis and concerns about recrudescence in areas of previous onchocerciasis ...
Peter D Burbelo +3 more
doaj +3 more sources
The genome of Onchocerca volvulus, agent of river blindness [PDF]
Nature Microbiology, 2016 AbstractHuman onchocerciasis is a serious neglected tropical disease caused by the filarial nematode Onchocerca volvulus that can lead to blindness and chronic disability. Control of the disease relies largely on mass administration of a single drug, and the development of new drugs and vaccines depends on a better knowledge of parasite biology.
James A Cotton +2 more
exaly +4 more sources
Pregnant Women, a Potential Reservoir for Onchocerca volvulus? A Cross Sectional Study in Maridi County, South Sudan [PDF]
Journal of Epidemiology and Global HealthBackground Onchocerciasis, a neglected tropical disease (NTD) caused by Onchocerca volvulus, is hyperendemic in many parts of Africa, including South Sudan.
Chiara Trevisan +7 more
doaj +2 more sources
The Functional Parasitic Worm Secretome: Mapping the Place of Onchocerca volvulus Excretory Secretory Products [PDF]
Pathogens, 2020 Nematodes constitute a very successful phylum, especially in terms of parasitism. Inside their mammalian hosts, parasitic nematodes mainly dwell in the digestive tract (geohelminths) or in the vascular system (filariae). One of their main characteristics
Luc Vanhamme +3 more
doaj +2 more sources
Virtual screening, MMGBSA, and molecular dynamics approaches for identification of natural products from South African biodiversity as potential Onchocerca volvulus pi-class glutathione S-transferase inhibitors [PDF]
HeliyonWe investigated 1012 molecules from natural products previously isolated from the South African biodiversity (SANCDB, https://sancdb.rubi.ru.ac.za/), for putative inhibition of Onchocerca volvulus pi-class glutathione S-transferase (Ov-GST2) by virtual ...
Mbah Bake Maraf +10 more
doaj +2 more sources
Observations onOnchocerca Volvulus
Annals of Tropical Medicine & Parasitology, 1922 J. W. S. Macfie, J. F. Corson
openaire +4 more sources