Results 51 to 60 of about 13,344 (260)

Modelling the elimination of river blindness using long-term epidemiological and programmatic data from Mali and Senegal [PDF]

open access: yes, 2017
The onchocerciasis transmission models EPIONCHO and ONCHOSIM have been independently developed and used to explore the feasibility of eliminating onchocerciasis from Africa with mass (annual or biannual) distribution of ivermectin within the timeframes ...
Basáñez, M-G   +7 more
core   +7 more sources

Advancing a Human Onchocerciasis Vaccine From Antigen Discovery to Efficacy Studies Against Natural Infection of Cattle With Onchocerca ochengi

open access: yesFrontiers in Cellular and Infection Microbiology, 2022
Human onchocerciasis is a devastating neglected tropical disease caused by infection of the filarial nematode Onchocerca volvulus. The infection can cause irreversible visual impairment or blindness and stigmatizing dermatitis.
Bin Zhan   +3 more
doaj   +1 more source

The Population Biology and Transmission Dynamics of Loa loa [PDF]

open access: yes, 2017
Endemic to Central Africa, loiasis – or African eye worm (caused by the filarial nematode Loa loa) – affects more than 10 million people. Despite causing ocular and systemic symptoms, it has typically been considered a benign condition, only of public ...
Basáñez, M-G   +5 more
core   +1 more source

Tolerability, Safety, and Pharmacokinetics of Ivermectin After Nasal Application in Healthy Adult Subjects

open access: yesThe Journal of Clinical Pharmacology, Volume 66, Issue 1, January 2026.
Abstract Nasal epithelium is the site of infection for SARS‐CoV2 viruses, with interactions of the viral spike protein with the ACE2 receptor of the host cell. Molecular docking studies have shown that ivermectin shields the spike protein and thereby prevents binding to ACE2.
Stefan Wissel   +5 more
wiley   +1 more source

Intestinal Parasites of Zoonotic Significance in Human and Domestic Animals in a Rural Setting in Nepal

open access: yesVeterinary Medicine and Science, Volume 12, Issue 1, January 2026.
Intestinal parasites are shared among humans and domestic animals. Rural setting is critical to enhance parasite zoonosis in Nepal. ABSTRACT Intestinal parasitic (IP) species with zoonotic significance are major public health issues, mostly prevalent in developing countries, leading to high morbidity and mortality. The present study aimed to assess the
Prince Rai, Tirth Raj Ghimire
wiley   +1 more source

Onchocerciasis control: biological research is still needed

open access: yesParasite, 2008
Achievements obtained by the onchocerciasis control programmes should not lead to a relaxation in the biological research on Onchocerca volvulus. Issues such as the Loa loa-related postivermectin serious adverse events, the uncertainties as to whether ...
Boussinesq M.
doaj   +1 more source

Unraveling cross-reactivity of anti-glycan IgG responses in filarial nematode infections

open access: yesFrontiers in Immunology, 2023
Parasitic nematodes responsible for filarial diseases cause chronic disablement in humans worldwide. Elimination programs have substantially reduced the rate of infection in certain areas, but limitations of current diagnostics for population ...
Laudine M. C. Petralia   +14 more
doaj   +1 more source

Efficacy of Immunostimulatory Adjuvants and Nano‐Adjuvants in Current SARS‐CoV‐2 Vaccines: A Comprehensive Review

open access: yesHealth Science Reports, Volume 8, Issue 11, November 2025.
ABSTRACT Background and Aims SARS‐CoV‐2 continues to pose global challenges, and current vaccines face limitations (variant escape, waning immunity). This review evaluates immunostimulatory adjuvants and nano‐adjuvants to enhance immune responses and optimize SARS‐CoV‐2 vaccine performance.
Peyman Kheirandish Zarandi   +5 more
wiley   +1 more source

A histochemical study of the Nras/let-60 activity in filarial nematodes [PDF]

open access: yes, 2015
BACKGROUND: Control and elimination of filarial pathogens is a central focus of major global health efforts directed at parasitic diseases of developing countries.
Charles Mackenzie   +8 more
core   +1 more source

Master of Puppets: How Microbiota Drive the Nematoda Ecology and Evolution?

open access: yesEcology and Evolution, Volume 15, Issue 8, August 2025.
The nematode microbiota can influence life‐history traits, thereby shaping the species' ecology and evolutionary trajectories. ABSTRACT In recent decades, the microbiota has emerged as a key driver of biological functions in metazoans, and nematodes are no exception.
Víctor José Trejo‐Meléndez   +1 more
wiley   +1 more source

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