Results 11 to 20 of about 18,365 (214)

Potential value of triple drug therapy with ivermectin, diethylcarbamazine, and albendazole (IDA) to accelerate elimination of lymphatic filariasis and onchocerciasis in Africa [PDF]

, 2017
Schistosomiasis affects millions of people, yet treatment options are limited. The antimalarial Synriam (piperaquine 150 mg/arterolane 750 mg) and the anthelminthic moxidectin revealed promising antischistosomal properties in preclinical or clinical ...
Fischer, Peter U, Jacobson, Julie A, King, Christopher L, Weil, Gary J   +3 more
core   +23 more sources

Repurposing Oxfendazole for Onchocerciasis: Population Pharmacokinetics of a Tablet Formulation in Healthy African Adults. [PDF]

CPT Pharmacometrics Syst Pharmacol
ABSTRACT Global efforts to eliminate onchocerciasis are hampered by the lack of a macrofilaricidal drug capable of killing adult parasites. Oxfendazole, a veterinary anthelminthic, exhibits macrofilaricidal activity and holds promise to shorten treatment durations.
Assmus F, Adehin A, Hoglund RM, Nyaulingo G, Mbarak H, Jongo S, Ackermann E, Reus E, Keiser J, Rocha FBDS, Specht S, Scandale I, Tarning J.   +12 more
europepmc   +2 more sources

Modelling the elimination of river blindness using long-term epidemiological and programmatic data from Mali and Senegal [PDF]

, 2017
The onchocerciasis transmission models EPIONCHO and ONCHOSIM have been independently developed and used to explore the feasibility of eliminating onchocerciasis from Africa with mass (annual or biannual) distribution of ivermectin within the timeframes ...
Basáñez, M-G, Bottomley, C, De Vlas, S J, Diawara, L, Dixon, M A, Stolk, W A, Traoré, M O, Walker, M   +7 more
core   +7 more sources

How can onchocerciasis elimination in Africa be accelerated? Modelling the impact of increased ivermectin treatment frequency and complementary vector control [PDF]

, 2017
Background: Great strides have been made toward onchocerciasis elimination by mass drug administration (MDA) of ivermectin. Focusing on MDA-eligible areas, we investigated where the elimination goal can be achieved by 2025 by continuation of current ...
Afework H Tekle, Alley, Annette C Kuesel, Basáñez, Basáñez, Basáñez, Bottomley, Boussinesq, Coffeng, Coffeng, Coffeng, Colebunders, Daniel A Boakye, Dyson, Filipe, GBD 2016 Disease and Injury Incidence and Prevalence Collaborators, Grace Fobi, Habbema, Honorat G M Zouré, Kaiser, Kamgno, Katabarwa, Kim, Little, Lont, Maria-Gloria Basáñez, Martin Walker, Matthews, Michel Boussinesq, Opoku, Plaisier, Plaisier, Plaisier, Sake J de Vlas, Samuel Wanji, Stolk, Stolk, Suzanne Verver, Tekle, Tekle, Traore, Turner, Turner, Turner, Turner, Walker, Walker, Walker, Walker, Wilma A Stolk, World Health Organization, World Health Organization, World Health Organization/African Programme for Onchocerciasis Control, World Health Organization/African Programme for Onchocerciasis Control, World Health Organization/African Programme for Onchocerciasis Control, World Health Organization/African Programme for Onchocerciasis Control, World Health Organization/African Programme for Onchocerciasis Control, Young Eun Kim, Zouré, Zouré   +59 more
core   +5 more sources

The burden of neglected tropical diseases in Ethiopia, and opportunities for integrated control and elimination [PDF]

, 2012
Background: Neglected tropical diseases (NTDs) are a group of chronic parasitic diseases and related conditions that are the most common diseases among the 2·7 billion people globally living on less than US$2 per day.
A Alemu, A Aseffa, A Deressa, A Haileamlak, A Yami, Abraham Aseffa, AD Bryceson, Ahmed Ali, AM Dorkenoo, Asrat Hailu, AZ Zein, B Erko, B Erko, B Liese, B Yakob, BA Boatin, C Bogh, C Hanson, C Prasittisuk, C Sikorski, Central Statistical Agency [Ethiopia], ICF International, D Fekadu, DG Addiss, DH Molyneux, DH Molyneux, DR ten Eyck, E Litt, E Negera, E Negera, E Ruiz-Tiben, E Yimer, EW Price, F Demissie, F Tekola, FMOH, FMOH, FMoH, G Davey, G Davey, G Davey, G Mengistu, G Tefera, Gail Davey, GS Smith, H Birrie, H Kloos, H Kloos, J Alvar, J Alvar, JH Kolaczinski, JH Kolaczinski, JO Gyapong, K Bogel, KA Grépin, Kadu Meribo, Kebede Deribe, L Erosie, L Jemaneh, M Fekadu, M Fekadu, M Herrero, MA Brady, MC Baker, Ministry of Health, MJ Burton, MJ Taylor, N Kebede, NB Kabatereine, P Steinmann, PJ Hotez, PJ Hotez, PJ Hotez, PJ Hotez, PJ Hotez, PM Emerson, R ter Horst, RL Pullan, RW Ashford, S Bashaye, S Brooker, S Brooker, S Cairncross, S Negash, SG Gundersen, T Wondimagegnehu, Teshome Gebre, The Carter Center, W Shiferaw, WHO, WHO, WHO, WHO, WHO, WHO, WHO, WHO, WHO, WHO, WHO, WHO, WHO, Y Berhane, Z Tadesse, ZA Zein   +103 more
core   +2 more sources

Human Onchocerciasis: Modelling the Potential Long-term Consequences of a Vaccination Programme. [PDF]

PLoS Neglected Tropical Diseases, 2015
BACKGROUND:Currently, the predominant onchocerciasis control strategy in Africa is annual mass drug administration (MDA) with ivermectin. However, there is a consensus among the global health community, supported by mathematical modelling, that ...
Hugo C Turner, Martin Walker, Sara Lustigman, David W Taylor, María-Gloria Basáñez   +4 more
doaj   +1 more source

Update on the current status of onchocerciasis in Cote d’Ivoire following 40 years of intervention: Progress and challenges [PDF]

, 2018
Background Onchocerciasis control in Côte d’Ivoire started with aerial insecticide spraying in 1974 and continued with community directed treatment with ivermectin (CDTi) from 1992 to the present.
Aba, Elvis, Brika, Pierre, Fischer, Peter U, King, Christopher L, Kouakou, Marie-Madeleine, Kouakou, Roger, Koudou, Benjamin G, Meite, Aboulaye, Ouattara, Allassane F, Weil, Gary J, Yeo, Souleymane   +10 more
core   +4 more sources

Mansonella perstans, Onchocerca volvulus and Strongyloides stercoralis infections in rural populations in central and southern Togo

Parasite Epidemiology and Control, 2018
Background: Mansonella perstans, Onchocerca volvulus and Strongyloides stercoralis are widespread helminth parasites in the tropics. Their distribution remains difficult to determine as it may change during national disease control programs and with ...
Francois Korbmacher, Kossi Komlan, Richard G. Gantin, Wiyao P. Poutouli, Koffi Padjoudoum, Potchoziou Karabou, Peter T. Soboslay, Carsten Köhler   +7 more
doaj   +1 more source

The geographic distribution of onchocerciasis in the 20 participating countries of the African Programme for Onchocerciasis Control: (1) priority areas for ivermectin treatment

Parasites & Vectors, 2014
Background The African Programme for Onchocerciasis Control (APOC) was created to control onchocerciasis as a public health problem in 20 African countries. Its main strategy is community directed treatment with ivermectin.
Mounkaila Noma, Honorat GM Zouré, Afework H Tekle, Peter AI Enyong, Bertram EB Nwoke, Jan HF Remme   +5 more
doaj   +1 more source

The World Health Organization 2030 goals for onchocerciasis: Insights and perspectives from mathematical modelling [version 1; peer review: 2 approved]

Gates Open Research, 2019
The World Health Organization (WHO) has embarked on a consultation process to refine the 2030 goals for priority neglected tropical diseases (NTDs), onchocerciasis among them.
NTD Modelling Consortium Onchocerciasis Group
doaj   +1 more source