Results 11 to 20 of about 8,184 (177)

Safety and immunogenicity of an adjuvanted human onchocerciasis vaccine candidate, <i>Ov</i>MANE1: preclinical evaluation in a mice model. [PDF]

Clin Transl Immunology
OvMANE1 formulated with Freund's adjuvant was safe and elicited strong humoral and cellular immune responses, including significant IgG and leukocyte activation. These findings highlight OvMANE1 as a promising multi‐epitope vaccine candidate for advancing onchocerciasis prevention.
Nebangwa DN, Efeti MT, Momnougui SME, Shintouo CM, Shey RA, Ayiseh RB, Ntie-Kang F, Ghogomu SM.   +7 more
europepmc   +2 more sources

Mansonella perstans, Onchocerca volvulus and Strongyloides stercoralis infections in rural populations in central and southern Togo

Parasite Epidemiology and Control, 2018
Background: Mansonella perstans, Onchocerca volvulus and Strongyloides stercoralis are widespread helminth parasites in the tropics. Their distribution remains difficult to determine as it may change during national disease control programs and with ...
Francois Korbmacher, Kossi Komlan, Richard G. Gantin, Wiyao P. Poutouli, Koffi Padjoudoum, Potchoziou Karabou, Peter T. Soboslay, Carsten Köhler   +7 more
doaj   +1 more source

The geographic distribution of onchocerciasis in the 20 participating countries of the African Programme for Onchocerciasis Control: (2) pre-control endemicity levels and estimated number infected

Parasites & Vectors, 2014
Background The original aim of the African Programme for Onchocerciasis Control (APOC) was to control onchocerciasis as a public health problem in 20 African countries.
Honorat GM Zouré, Mounkaila Noma, Afework H Tekle, Uche V Amazigo, Peter J Diggle, Emanuele Giorgi, Jan HF Remme   +6 more
doaj   +1 more source

The World Health Organization 2030 goals for onchocerciasis: Insights and perspectives from mathematical modelling [version 1; peer review: 2 approved]

Gates Open Research, 2019
The World Health Organization (WHO) has embarked on a consultation process to refine the 2030 goals for priority neglected tropical diseases (NTDs), onchocerciasis among them.
NTD Modelling Consortium Onchocerciasis Group
doaj   +1 more source

Onchocerciasis Prevalence among Persons with Epilepsy in an Onchocerciasis Hypo-Endemic Area in the Democratic Republic of Congo: A Cross-Sectional Study

Pathogens, 2021
A high epilepsy prevalence has been reported in onchocerciasis meso- and hyper-endemic regions in sub-Saharan Africa, including in the Democratic Republic of Congo (DRC). We investigated whether onchocerciasis-associated epilepsy can also be suspected in
An Hotterbeekx, Kristien Verdonck, Deby Mukendi, Jean-Roger Lilo-Kalo, Pascal Lutumba, Marleen Boelaert, Liselotte Hardy, Barbara Barbé, Jan Jacobs, Emmanuel Bottieau, Robert Colebunders   +10 more
doaj   +1 more source

The geographic distribution of onchocerciasis in the 20 participating countries of the African Programme for Onchocerciasis Control: (1) priority areas for ivermectin treatment

Parasites & Vectors, 2014
Background The African Programme for Onchocerciasis Control (APOC) was created to control onchocerciasis as a public health problem in 20 African countries. Its main strategy is community directed treatment with ivermectin.
Mounkaila Noma, Honorat GM Zouré, Afework H Tekle, Peter AI Enyong, Bertram EB Nwoke, Jan HF Remme   +5 more
doaj   +1 more source

Nodding syndrome research, lessons learned from the NSETHIO project

Cambridge Prisms: Global Mental Health, 2019
Background.Until recently, nodding syndrome (NS) was considered as a mysterious disease of unknown etiology. A link between onchocerciasis and epilepsy was suspected for a long time.
D. Geelhand de Merxem, J. N. Siewe Fodjo, S. Menon, A. Hotterbeekx, R. Colebunders   +4 more
doaj   +1 more source

Diagnosis of O. volvulus infection via skin exposure to diethylcarbamazine: clinical evaluation of a transdermal delivery technology-based patch

Parasites & Vectors, 2015
Background Elimination of onchocerciasis in Africa is now regarded as an achievable goal in many areas. This makes monitoring changes in infection prevalence a key component of control programmes. Monitoring is currently based on determining the presence
K. Awadzi, Nicholas O. Opoku, Simon K. Attah, Janis K. Lazdins-Helds, Annette C. Kuesel   +4 more
doaj   +1 more source

Elimination of onchocerciasis in Africa by 2025: an ambitious target requires ambitious interventions

Infectious Diseases of Poverty, 2019
To achieve the elimination of onchocerciasis transmission in all African countries will entail enormous challenges, as has been highlighted by the active discussion around onchocerciasis intervention strategies and evaluation procedures in this journal ...
Robert Colebunders, Wilma A. Stolk, Joseph Nelson Siewe Fodjo, Charles D. Mackenzie, Adrian Hopkins   +4 more
doaj   +1 more source

Is onchocerciasis elimination in Africa feasible by 2025: a perspective based on lessons learnt from the African control programmes

Infectious Diseases of Poverty, 2018
Background Onchocerciasis is found predominantly in Africa where large scale vector control started in 1974. Registration and donation of ivermectin by Merck & Co in 1987 enabled mass treatment with ivermectin in all endemic countries in Africa and the ...
Yankum Dadzie, Uche V. Amazigo, Boakye A. Boatin, Azodoga Sékétéli   +3 more
doaj   +1 more source