Oncolytic Herpes Simplex Virus-Based Therapies for Cancer [PDF]
Cells, 2021 With the increased worldwide burden of cancer, including aggressive and resistant cancers, oncolytic virotherapy has emerged as a viable therapeutic option.
Norah Aldrak +7 more
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Replication and Spread of Oncolytic Herpes Simplex Virus in Solid Tumors [PDF]
Viruses, 2022 Oncolytic herpes simplex virus (oHSV) is a highly promising treatment for solid tumors. Intense research and development efforts have led to first-in-class approval for an oHSV for melanoma, but barriers to this promising therapy still exist that limit ...
Bangxing Hong +3 more
doaj +4 more sources
Advances in oncolytic herpes simplex virus and adenovirus therapy for recurrent glioma [PDF]
Frontiers in Immunology, 2023 Recurrent glioma treatment is challenging due to molecular heterogeneity and treatment resistance commonly observed in these tumors. Researchers are actively pursuing new therapeutic strategies.
Mingming Hu +7 more
doaj +2 more sources
Eliciting an immune-mediated antitumor response through oncolytic herpes simplex virus-based shared antigen expression in tumors resistant to viroimmunotherapy [PDF]
Journal for ImmunoTherapy of Cancer, 2021 Background Oncolytic virotherapy (OV) is an immunotherapy that incorporates viral cancer cell lysis with engagement of the recruited immune response against cancer cells.
Chun-Yu Chen +13 more
doaj +2 more sources
Oncolytic Herpes Simplex Virus Prevents Premalignant Lesions from Progressing to Cancer
Molecular Therapy: Oncolytics, 2020 Early detection and timely treatment of precancerous lesions are hallmarks of successful strategies to prevent deaths due to cancer. Oncolytic viruses are a group of promising anti-cancer agents with wide-ranging experimental and clinical efficacy ...
Yanghee Woo +5 more
doaj +3 more sources
Oncolytic herpes simplex virus and immunotherapy [PDF]
BMC Immunology, 2018 Background Oncolytic viruses have been proposed to be employed as a potential treatment of cancer. Well targeted, they will serve the purpose of cracking tumor cells without causing damage to normal cells.
Wenqing Ma, Hongbin He, Hongmei Wang
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Investigation of an oncolytic herpes simplex virus as a potential therapeutic agent for gastroenteropancreatic neuroendocrine neoplasms [PDF]
Scientific ReportsGastroenteropancreatic neuroendocrine tumors (GEP-NETs) present unique challenges due to their heterogeneity and limited treatment options. Oncolytic virotherapy has emerged as a promising therapeutic for other NETs and thus, we sought to investigate the
Colin H. Quinn +10 more
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Advances in the Drug Development and Quality Evaluation Principles of Oncolytic Herpes Simplex Virus [PDF]
VirusesOncolytic herpes simplex virus (oHSV) represents a promising therapeutic approach to treating cancers by virtue of its selective replication in and lysis of tumor cells, with stimulation of host antitumor immunity.
Basma Eid Abdullah Ghorab +7 more
doaj +2 more sources
The Current State of Oncolytic Herpes Simplex Virus for Glioblastoma Treatment [PDF]
Oncolytic Virotherapy, 2021 Dipongkor Saha, Hong-Mỹ Nguyen
exaly +2 more sources
Efficacy of a third-generation oncolytic herpes simplex virus in refractory soft tissue sarcoma xenograft models [PDF]
Molecular Therapy - Oncolytics, 2022 Tadayoshi Okumura +2 more
exaly +2 more sources