Results 171 to 180 of about 8,958 (210)

Lactobacillus acidophilus potentiates oncolytic virotherapy through modulating gut microbiota homeostasis in hepatocellular carcinoma. [PDF]

Nat Commun
Zhang J, Yang J, Luo J, Wu W, Luo H, Wei W, Lyu H, Wang Y, Yi H, Zhang Y, Fan Z, Lyu H, Kanakaveti VP, Qin B, Yuan P, Yang R, Zhang H, Zuo T, Felsher DW, Lee MH, Li K.   +20 more
europepmc   +1 more source

Blocking Feedback Immunosuppression of Antigen Presentation in Brain Tumor During Oncolytic Virotherapy with oHSV-mshPKR. [PDF]

Mol Cancer Ther
Tsuboi N, Rivera-Caraballo KA, Sahu U, Pacholczyk R, Douglass E, Johnson TS, Wang Q, Kolhe R, Hedrick CC, Munn DH, Hong B.   +10 more
europepmc   +1 more source

Enhancing oncolytic virotherapy by extracellular vesicle mediated microRNA reprograming of the tumour microenvironment. [PDF]

Front Immunol
Jennings VA, Rumbold-Hall R, Migneco G, Barr T, Reilly K, Ingram N, St Hilare I, Heaton S, Alzamel N, Jackson D, Ralph C, Banerjee S, McNeish I, Bell JC, Melcher AA, Ilkow C, Cook GP, Errington-Mais F.   +17 more
europepmc   +1 more source

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Oncolytic Virotherapy

2023
Oncolytic virotherapy opens up avenues for cancer treatment by selectively targeting the cancer cells and destructs them either through direct lysis or by inducing an immune response in the tumor microenvironment. This platform technology utilizes a diverse range naturally existing or genetically modified oncolytic viruses for their immunotherapeutic ...
Munazza, Fatima, Deeba, Amraiz, Muhammad Tariq, Navid   +2 more
openaire   +3 more sources

Poxvirus oncolytic virotherapy

Expert Opinion on Biological Therapy, 2019
Over the last decade, advances in biological therapies have resulted in remarkable clinical responses for the treatment of some previously incurable cancers. Oncolytic virotherapy is one of these promising novel strategies for cancer therapy. A successful oncolytic virus promotes tumor cell oncolysis and elicits a robust long-term anti-tumor immunity ...
Grant Mcfadden
exaly   +3 more sources

Oncolytic virotherapy: Challenges and solutions

Current Problems in Cancer, 2021
Viruses as cancer therapies have attracted attention since the 19th century. Scientists observation that viruses can preferentially lyse cancer cells rather than healthy cells, created the field of oncolytic virology. Like other therapeutic strategies, oncolytic virotherapy has challenges, such as penetration into tumor bulk, anti-viral immune ...
Nasser Hashemi Goradel, Alexander T Baker, Arash Arashkia   +2 more
exaly   +3 more sources

Oncolytic virotherapy as immunotherapy

Science, 2021
Recognizing immune responses to oncolytic virotherapy opens the way for new ...
Alan, Melcher, Kevin, Harrington, Richard, Vile   +2 more
openaire   +2 more sources

Oncolytic Virotherapy

Journal of Vascular and Interventional Radiology, 2013
Oncolytic virotherapy is an emerging technology that uses engineered viruses to treat malignancies. Viruses can be designed with biological specificity to infect cancerous cells preferentially, and to replicate in these cells exclusively. Malignant cells may be killed directly by overwhelming viral infection and lysis, which releases additional viral ...
Daniel Y, Sze, Tony R, Reid, Steven C, Rose   +2 more
openaire   +2 more sources

Oncolytic Virotherapy by HSV

2018
Oncolytic virotherapy is a kind of antitumor therapy using viruses with natural or engineered tumor-selective replication to intentionally infect and kill tumor cells. An early clinical trial has been performed in the 1950s using wild-type and non-engineered in vitro-passaged virus strains and vaccine strains (first generation oncolytic viruses ...
Daisuke, Watanabe, Fumi, Goshima
openaire   +2 more sources

Oncolytic virotherapies for pediatric tumors

Expert Opinion on Biological Therapy, 2023
Many pediatric patients with malignant tumors continue to suffer poor outcomes. The current standard of care includes maximum safe surgical resection followed by chemotherapy and radiation which may be associated with considerable long-term morbidity.
Evan G Gross, Mohammad A Hamo, Dagoberto Estevez-Ordonez, Nicholas MB Laskay, Travis J Atchley, James M Johnston, James M Markert   +6 more
openaire   +2 more sources