Results 41 to 50 of about 7,402 (232)
The Role of Neutrophils in Oncolytic Orf Virus-Mediated Cancer Immunotherapy
Cells, 2022 Neutrophils are innate leukocytes with diverse effector functions that allow them to respond to pathogens rapidly. Accumulating evidence has highlighted these cells’ complex roles in the host’s response to viral infections and tumor progression ...
Jessica A. Minott +5 more
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CANCER GROWTH TREATMENT USING IMMUNE LINEAR QUADRATIC REGULATOR BASED ON CROW SEARCH OPTIMIZATION ALGORITHM [PDF]
Applied Computer Science, 2021 The rapid and uncontrollable cell division that spreads to surrounding tissues medically termed as malignant neoplasm, cancer is one of the most common diseases worldwide.
Mohammed A. HUSSEIN +2 more
doaj +1 more source
Oncolytic Virotherapy and Microenvironment in Multiple Myeloma [PDF]
International Journal of Molecular Sciences, 2021 Multiple myeloma (MM) is a hematologic malignancy characterized by the accumulation of bone marrow (BM) clonal plasma cells, which are strictly dependent on the microenvironment. Despite the improvement of MM survival with the use of new drugs, MM patients still relapse and become always refractory to the treatment.
Valentina Marchica +3 more
openaire +4 more sources
Tumor Restrictions to Oncolytic Virus
Biomedicines, 2014 Oncolytic virotherapy has advanced since the days of its conception but therapeutic efficacy in the clinics does not seem to reach the same level as in animal models.
Markus Vähä-Koskela, Ari Hinkkanen
doaj +1 more source
Oncolytic polio virotherapy of cancer [PDF]
Cancer, 2014 Recently, the century‐old idea of targeting cancer with viruses (oncolytic viruses) has come of age, and promise has been documented in early stage and several late‐stage clinical trials in a variety of cancers. Although originally prized for their direct tumor cytotoxicity (oncolytic virotherapy), recently, the proinflammatory and immunogenic effects ...
John H. Sampson +12 more
openaire +3 more sources
Oncolytic Virotherapy for Cancer: Clinical Experience [PDF]
Biomedicines, 2021 Oncolytic viruses are a new class of therapeutics which are largely in the experimental stage, with just one virus approved by the FDA thus far. While the concept of oncolytic virotherapy is not new, advancements in the fields of molecular biology and virology have renewed the interest in using viruses as oncolytic agents.
Shyambabu Chaurasiya +2 more
openaire +4 more sources
Viruses, 2015 Oncolytic virotherapy for cancer is an innovative therapeutic option where the ability of a virus to promote cell lysis is harnessed and reprogrammed to selectively destroy cancer cells.
Janice Kim +3 more
doaj +1 more source
Oscillation thresholds via the novel MBR method with application to oncolytic virotherapy
Nonlinear Analysis, 2022 Oncolytic virotherapy is a therapy for the treatment of malignant tumours. In some undesirable cases, the injection of viral particles can lead to stationary oscillations, thus preventing the full destruction of the tumour mass.
Bruno Buonomo +2 more
doaj +1 more source
Nonlocal multiscale modelling of tumour-oncolytic viruses interactions within a heterogeneous fibrous/non-fibrous extracellular matrix [PDF]
arXiv, 2021 In this study we investigate computationally tumour-oncolytic virus(OV) interactions that take place within a heterogeneous ExtraCellular Matrix (ECM). The ECM is viewed as a mixture of two constitutive phases, namely a fibre phase and a non-fibre phase.
arxiv