Results 41 to 50 of about 28,421 (276)
IDH1 mutation impairs antiviral response and potentiates oncolytic virotherapy in glioma
Nature Communications, 2023 IDH1 mutations frequently occur early in human glioma. While IDH1 mutation has been shown to promote gliomagenesis via DNA and histone methylation, little is known regarding its regulation in antiviral immunity.
Xueqin Chen +24 more
semanticscholar +1 more source
Oncolytic virotherapy and the current approaches in veterinary medicine
German Journal of Veterinary Research, 2022 Cancer has an increasing incidence worldwide in humans and animals. In addition to traditional treatments such as surgery, radiotherapy, and chemotherapy, there is a search for new treatment strategies for cancer treatment.
Bengu Bilgic, Banu Dokuzeylul, Mehmet Or
doaj +1 more source
Oncolytic virotherapy evolved into the fourth generation as tumor immunotherapy
Journal of Translational Medicine, 2023 Background Oncolytic virotherapy (OVT) is a promising anti-tumor modality that utilizes oncolytic viruses (OVs) to preferentially attack cancers rather than normal tissues.
Xianwang Wang +10 more
semanticscholar +1 more source
Dendritic cells and natural killer cells: The road to a successful oncolytic virotherapy
Frontiers in Immunology, 2023 Every type of cancer tissue is theoretically more vulnerable to viral infection. This natural proclivity has been harnessed as a new anti-cancer therapy by employing oncolytic viruses (OVs) to selectively infect and destroy cancer cells while providing ...
Matin Ghasemi +5 more
semanticscholar +1 more source
Immunosuppressive cells in oncolytic virotherapy for glioma: challenges and solutions
Frontiers in Cellular and Infection Microbiology, 2023 Glioblastoma is a highly aggressive form of brain cancer characterized by the abundance of myeloid lineage cells in the tumor microenvironment. Tumor-associated macrophages and microglia (TAM) and myeloid-derived suppressor cells (MDSCs), play a pivotal ...
Junfeng Liu +5 more
semanticscholar +1 more source
Molecular Therapy: Oncolytics, 2021 The oncolytic effect of virotherapy derives from the intrinsic capability of the applied virus in selectively infecting and killing tumor cells. Although oncolytic viruses of various constructions have been shown to efficiently infect and kill tumor ...
Divya Ravirala +3 more
doaj +1 more source
Immuno, 2023 Despite advances in treatment options, the clinical outcomes of pediatric patients with advanced solid tumors have hardly improved in decades, and alternative treatment options are urgently needed. Innovative therapies, such as chimeric antigen receptor (
Jianming He +8 more
semanticscholar +1 more source
Infection of non-cancer cells: A barrier or support for oncolytic virotherapy?
Molecular Therapy: Oncolytics, 2022 Oncolytic viruses are designed to specifically target cancer cells, sparing normal cells. Although numerous studies demonstrate the ability of oncolytic viruses to infect a wide range of non-tumor cells, the significance of this phenomenon for cancer ...
Victor A. Naumenko +4 more
doaj +1 more source
Advances in the design and development of oncolytic measles viruses. [PDF]
, 2015 A successful oncolytic virus is one that selectively propagates and destroys cancerous tissue without causing excessive damage to the normal surrounding tissue. Oncolytic measles virus (MV) is one such virus that exhibits this characteristic and thus has
Hutzen, Brian +2 more
core +1 more source
Current Status and Challenges of Oncolytic Virotherapy for the Treatment of Glioblastoma
Pharmaceuticals, 2023 Despite decades of research and numerous clinical trials, the prognosis of patients diagnosed with glioblastoma (GBM) remains dire with median observed survival at 8 months.
M. Webb, U. Sener, R. Vile
semanticscholar +1 more source