Results 81 to 90 of about 7,402 (232)
International Journal of Hyperthermia, 2019 Objective: To validate the feasibility of molecular imaging-monitored intratumoral radiofrequency hyperthermia (RFH) enhanced direct oncolytic virotherapy for hepatocellular carcinoma (HCC).
Jingjing Song +8 more
doaj +1 more source
Evidence for Oncolytic Virotherapy: Where Have We Got to and Where Are We Going?
Viruses, 2015 The last few years have seen an increased interest in immunotherapy in the treatment of malignant disease. In particular, there has been significant enthusiasm for oncolytic virotherapy, with a large amount of pre-clinical data showing promise in animal ...
Samantha Turnbull +5 more
doaj +1 more source
Advanced Science, Volume 11, Issue 44, November 26, 2024.Post‐translational modifications (PTMs) of RNA‐modifying proteins, such as METTL3 and METTL14, modulate their activity and interactions, impacting transcription, signaling pathways, and immune responses. These processes are crucial in driving cancer progression, immune evasion, and pathogen responses, making PTMs of RNA modifiers potential therapeutic ...
Yunfan Lin +7 more
wiley +1 more source
Reduction and Hamiltonian aspects of a model for virus-tumour interaction in oncolytic virotherapy [PDF]
arXiv, 2019 We analyse the Hamiltonian structure of a system of first-order ordinary differential equations used for modeling the interaction of an oncolytic virus with a tumour cell population. The analysis is based on the existence of a Jacobi Last Multiplier for the system and a time dependent first integral. For suitable conditions on the model parameters this
arxiv
Asymptotic stability of spatial homogeneity in a haptotxis model for oncolytic virotherapy [PDF]
arXiv, 2020 This work considers a model for oncolytic virotherapy, as given by the reaction-diffusion-taxis system $$ \left\{ \begin{array}{l} u_t = \Delta u - \nabla \cdot (u\nabla v)-\rho uz, \\[1mm] v_t = - (u+w)v, \\[1mm] w_t = D_w \Delta w - w + uz, \\[1mm] z_t = D_z \Delta z - z - uz + \beta w, \end{array} \right.
arxiv
Molecular Oncology, Volume 19, Issue S1, Page 1-895, June 2025.Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 30, Issue 11, November 2024.On the basis of oncolytic adenovirus TS‐2021 infection caused PARP activation. The combination of TS‐2021 and olaparib increases virus titer, p66shc phosphorylation, reactive oxygen species production, and DNA damage, leading to synergistic apoptosis in GBM.
Yida Liu +4 more
wiley +1 more source
Journal for ImmunoTherapy of Cancer, 2018 Antiviral responses are barriers that must be overcome for efficacy of oncolytic virotherapy. In mammalian cells, antiviral responses involve the interferon pathway, a protein-signaling cascade that alerts the immune system and limits virus propagation ...
Donald Bastin +8 more
doaj +1 more source
Virotheranostics, a double-barreled viral gun pointed toward cancer; ready to shoot?
Cancer Cell International, 2020 Compared with conventional cancer treatments, the main advantage of oncolytic virotherapy is its tumor-selective replication followed by the destruction of malignant cells without damaging healthy cells.
Mohsen Keshavarz +5 more
doaj +1 more source
Beyond the Gut: The intratumoral microbiome's influence on tumorigenesis and treatment response
Cancer Communications, Volume 44, Issue 10, Page 1130-1167, October 2024.Abstract The intratumoral microbiome (TM) refers to the microorganisms in the tumor tissues, including bacteria, fungi, viruses, and so on, and is distinct from the gut microbiome and circulating microbiota. TM is strongly associated with tumorigenesis, progression, metastasis, and response to therapy.
Hao Zhang +10 more
wiley +1 more source