Results 81 to 90 of about 28,421 (276)

Multiscale model for the effects of adaptive immunity suppression on the viral therapy of cancer

, 2013
Oncolytic virotherapy - the use of viruses that specifically kill tumor cells - is an innovative and highly promising route for treating cancer. However, its therapeutic outcomes are mainly impaired by the host immune response to the viral infection.
Ferreira, Silvio C, Martins, Marcelo L, Paiva, Leticia R, Silva, Hallan S   +3 more
core   +2 more sources

Oncolytic Virotherapy: A New Paradigm in Cancer Immunotherapy

International Journal of Molecular Sciences
Oncolytic viruses (OVs) are emerging as potential treatment options for cancer. Natural and genetically engineered viruses exhibit various antitumor mechanisms.
S. Volovat, D. Scripcariu, I. Vasilache, C. Stolniceanu, C. Volovăț, I. Augustin, C. Volovăț, Mădălina-Raluca Ostafe, Slevoacă-Grigore Andreea-Voichița, Toni Bejusca-Vieriu, C. Lungulescu, D. Sur, Diana Boboc   +12 more
semanticscholar   +1 more source

Combining of Oncolytic Virotherapy and Other Immunotherapeutic Approaches in Cancer: A Powerful Functionalization Tactic

Global Challenges, 2022
Oncolytic viruses have found a good place in the treatment of cancer. Administering oncolytic viruses directly or by applying genetic changes can be effective in cancer treatment through the lysis of tumor cells and, in some cases, by inducing immune ...
Hai Zou, X. Mou, Biao Zhu
semanticscholar   +1 more source

Oscillation thresholds via the novel MBR method with application to oncolytic virotherapy

Nonlinear Analysis, 2022
Oncolytic virotherapy is a therapy for the treatment of malignant tumours. In some undesirable cases, the injection of viral particles can lead to stationary oscillations, thus preventing the full destruction of the tumour mass.
Bruno Buonomo, Rossella Della Marca, Salvatore Rionero   +2 more
doaj   +1 more source

Immunotherapeutic potential of oncolytic vaccinia virus [PDF]

, 2014
The concept of oncolytic viral therapy was based on the hypothesis that engineering tumor-selectivity into the replication potential of viruses would permit direct destruction of tumor cells as a result of viral-mediated lysis, resulting in amplification
Thorne, SH
core   +1 more source

Stem Cell-Based Cell Carrier for Targeted Oncolytic Virotherapy: Translational Opportunity and Open Questions

Viruses, 2015
Oncolytic virotherapy for cancer is an innovative therapeutic option where the ability of a virus to promote cell lysis is harnessed and reprogrammed to selectively destroy cancer cells.
Janice Kim, Robert R. Hall, Maciej S. Lesniak, Atique U. Ahmed   +3 more
doaj   +1 more source

Atomic Resolution Structure of the Oncolytic Parvovirus LuIII by Electron Microscopy and 3D Image Reconstruction. [PDF]

, 2017
LuIII, a protoparvovirus pathogenic to rodents, replicates in human mitotic cells, making it applicable for use to kill cancer cells. This virus group includes H-1 parvovirus (H-1PV) and minute virus of mice (MVM).
Agbandje-McKenna, Mavis, Baker, Timothy S, Chipman, Paul, Cotmore, Susan, D'Abramo, Anthony, Geilen, Lorena, Halder, Sujata, Janssen, Mandy, Kurian, Justin, Mckenna, Robert, Misseldine, Adam, Pittman, Nikéa, Smith, J Kennon, Tattersall, Peter   +13 more
core   +3 more sources

Efficient Prodrug Activator Gene Therapy by Retroviral Replicating Vectors Prolongs Survival in an Immune-Competent Intracerebral Glioma Model. [PDF]

, 2020
Prodrug activator gene therapy mediated by murine leukemia virus (MLV)-based retroviral replicating vectors (RRV) was previously shown to be highly effective in killing glioma cells both in culture and in vivo.
Chang, Deching, Chang, Hao-Fang, Chen, Bing-Mao, Chen, Shih-Han, Chen, Thomas C, Collins, Sara, Kasahara, Noriyuki, Lin, Sheng-Che, Lu, Yin-Che, Sun, Jui-Ming, Tai, Chien-Kuo, Wang, Hsin-Ell, Wang, Weijun, Wu, Shu-Fen   +13 more
core   +2 more sources

Oncolytic Virotherapy in Solid Tumors: The Challenges and Achievements

Cancers, 2021
Simple Summary Oncolytic virotherapy (OVT) is a promising approach in cancer immunotherapy. Oncolytic viruses (OVs) could be applied in cancer immunotherapy without in-depth knowledge of tumor antigens.
Ke-Tao Jin, Wen-Lin Du, Yuyao Liu, H. Lan, Jingxing Si, X. Mou   +5 more
semanticscholar   +1 more source

Enhancement of chemotherapy using oncolytic virotherapy: Mathematical and optimal control analysis

, 2018
Oncolytic virotherapy (OV) has been emerging as a promising novel cancer treatment that may be further combined with the existing therapeutic modalities to enhance their effects.
Eladdadi, Amina, Malinzi, Joseph, Ouifki, Rachid, Torres, Delfim F. M., White, K. A. Jane   +4 more
core   +1 more source