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Oncolytic vaccinia virus for the treatment of cancer

Expert Opinion on Biological Therapy, 2011
Gene therapy offers promising approaches for the development of anticancer agents with new modes of action. Among gene therapy vectors, vaccinia virus has emerged as an attractive agent especially when used as an oncolytic virus.This review describes the use of vaccinia virus in cancer therapy as a gene therapy vector, as an oncolytic virus and in the ...
Kilian, Guse   +2 more
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Modification of HSV-1 to an Oncolytic Virus

2014
Cancer-permissive viruses or oncolytic viruses consist of either genetically engineered or naturally occurring strains that possess relatively selective replicative and/or infection abilities for cancer vs. normal cells (Chiocca, Nat Rev Cancer 2: 938-950, 2002).
Hiroshi, Nakashima, E Antonio, Chiocca
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Oncolytic virus therapy for prostate cancer

International Journal of Urology, 2009
AbstractThe use of replication‐competent viruses that can selectively replicate in and destroy neoplastic cells is an attractive strategy for treating cancer. Various oncolytic viruses have been taken to clinical trials since a recombinant virus was first applied to cancer patients a decade ago.
Hiroshi, Fukuhara   +2 more
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Recent advances in oncolytic virus design

Clinical and Translational Oncology, 2011
The cytolytic properties of viruses can be used to treat cancer. Replication of certain viruses is favoured in cancer cells, whereas others can be modified to obtain tumour specificity. This approach has evolved to become a new discipline called virotherapy.
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Vesicular Stomatitis Virus as an Oncolytic Vector

Viral Immunology, 2004
Recent data has shown that viruses such as vesicular stomatitis virus (VSV), a relatively non-pathogenic, negative-stranded RNA virus, can preferentially replicate in malignant cells and less so in normal cells. VSV appears able to carry out this function in transformed cells since these hosts exhibit the hallmarks of flawed host defense, probably ...
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Progress in oncolytic and immunotherapy of measles virus

Minerva Medica
Yongping, He   +3 more
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