Results 11 to 20 of about 21,338 (215)
The Oncolytic Virus in Cancer Diagnosis and Treatment [PDF]
Frontiers in Oncology, 2020 Cancer has always been an enormous threat to human health and survival. Surgery, radiotherapy, and chemotherapy could improve the survival of cancer patients, but most patients with advanced cancer usually have a poor survival or could not afford the ...
Guo-dong Cao +9 more
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Neutrophils in oncolytic virus immunotherapy. [PDF]
Front ImmunolOncolytic viruses have emerged as a highly promising modality for cancer treatment due to their ability to replicate specifically within tumors, carry therapeutic genes, and modulate the immunosuppressive tumor microenvironment through various mechanisms. Additionally, they show potential synergy with immune checkpoint inhibitors.
Zhou D, Zhang C, Sun J, Yuan M.
europepmc +4 more sources
Oncolytic Virus Immunotherapy [PDF]
Cancers, 2021 Oncolytic viruses (OVs) were originally developed as direct cytotoxic agents but have been increasingly recognised as a form of immunotherapy [...]
Carolina S. Ilkow +3 more
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Measles Virus as an Oncolytic Immunotherapy [PDF]
Cancers, 2021 Measles virus (MeV) preferentially replicates in malignant cells, leading to tumor lysis and priming of antitumor immunity. Live attenuated MeV vaccine strains are therefore under investigation as cancer therapeutics. The versatile MeV reverse genetics systems allows for engineering of advanced targeted, armed, and shielded oncolytic viral vectors ...
Christine E. Engeland, Guy Ungerechts
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Oncolytic Virotherapy with Myxoma Virus [PDF]
Journal of Clinical Medicine, 2020 Oncolytic viruses are one of the most promising novel therapeutics for malignant cancers. They selectively infect and kill cancer cells while sparing the normal counterparts, expose cancer- specific antigens and activate the host immune system against both viral and tumor determinants.
Masmudur M. Rahman, Grant McFadden
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Oncolytic Virus-Induced Autophagy in Glioblastoma [PDF]
Cancers, 2021 Autophagy is a catabolic process that allows cells to scavenge damaged organelles and produces energy to maintain cellular homeostasis. It is also an effective defense method for cells, which allows them to identify an internalized pathogen and destroy it through the fusion of the autophagosome and lysosomes.
Peter S. Timashev +7 more
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Tumor Restrictions to Oncolytic Virus [PDF]
Biomedicines, 2014 Oncolytic virotherapy has advanced since the days of its conception but therapeutic efficacy in the clinics does not seem to reach the same level as in animal models. One reason is premature oncolytic virus clearance in humans, which is a reasonable assumption considering the immune-stimulating nature of the oncolytic agents.
Markus Vähä-Koskela, Ari Hinkkanen
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Adenovirus as a Vector and Oncolytic Virus
Current Issues in Molecular Biology, 2023 Adenoviral vectors, both oncolytic viruses and gene delivery vectors, are among the earliest approved and commercialised vectors for gene therapy. Adenoviruses have high cytotoxicity and immunogenicity. Therefore, lentiviruses or adeno-associated viruses as viral vectors and herpes simplex virus as an oncolytic virus have recently drawn attention. Thus,
Wataru Matsunaga, Akinobu Gotoh
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Frontiers in Immunology, 2019 Cancer cells utilize multiple mechanisms to evade and suppress anticancer immune responses creating a “cold” immunosuppressive tumor microenvironment. Oncolytic virotherapy is emerging as a promising approach to revert tumor immunosuppression and enhance
Antonio Marchini +6 more
doaj +1 more source
Oncolytic herpes simplex virus and immunotherapy [PDF]
BMC Immunology, 2018 Oncolytic viruses have been proposed to be employed as a potential treatment of cancer. Well targeted, they will serve the purpose of cracking tumor cells without causing damage to normal cells. In this category of oncolytic viral drugs human pathogens herpes simplex virus (HSV) is especially suitable for the cause. Although most viral infection causes
Wenqing Ma, Hongbin He, Hongmei Wang
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