Results 21 to 30 of about 21,338 (215)
Updates to the antitumor mechanism of oncolytic virus [PDF]
Thoracic Cancer, 2019 Oncolytic viruses (OVs) are promising new therapeutic agents in the field of malignant tumor treatment. OVs can achieve the goal of targeted therapy by selectively killing tumor cells and inducing specific antitumor immunity. The key roles of OVs are tumor targeting and tumor killing mechanisms.
Yang Bai, Peng Hui, Xiaoyu Du, Xing Su
openaire +2 more sources
Viruses, 2020 We studied whether cytosine phosphate–guanine (CpG) recoding in a viral genome may provide oncolytic candidates with reduced infection kinetics in nonmalignant brain cells, but with high virulence in glioblastoma stem cells (GSCs).
Ivan Trus +5 more
doaj +1 more source
Marine Drugs, 2022 Oncolytic vaccinia virus has been developed as a novel cancer therapeutic drug in recent years. Our previous studies demonstrated that the antitumor effect of oncolytic vaccina virus harboring Aphrocallistes vastus lectin (oncoVV-AVL) was significantly ...
Riqing Jiang +8 more
doaj +1 more source
Research progress of oncolytic virus combined with PD-1/PD-L1 inhibitors [PDF]
Jichu yixue yu linchuang, 2022 Oncolytic viruses are often used in combination with immune checkpoint inhibitors represented in two ways by programmed cell death 1/programmed cell death-Ligand 1 (PD-1/PD-L1).
GAN Zi-ying, TANG Hui
doaj +1 more source
Adaptation of transgene mRNA translation boosts the anticancer efficacy of oncolytic HSV1
Journal for ImmunoTherapy of Cancer, 2023 Background Transgenes deliver therapeutic payloads to improve oncolytic virus immunotherapy. Transgenes encoded within oncolytic viruses are designed to be highly transcribed, but protein synthesis is often negatively affected by viral infection ...
Huy-Dung Hoang +15 more
doaj +1 more source
Oncolytic virus therapy for cancer
Oncolytic Virotherapy, 2013 The use of oncolytic viruses to treat cancer is based on the selection of tropic tumor viruses or the generation of replication selective vectors that can either directly kill infected tumor cells or increase their susceptibility to cell death and apoptosis through additional exposure to radiation or chemotherapy.
Sara Harcharik +9 more
openaire +5 more sources
Updates on Oncolytic Virus Immunotherapy for Cancers [PDF]
Molecular Therapy Oncolytics, 2019 The 2018 annual Cambridge Healthtech Institute's International Immuno-Oncology Summit in Boston, MA convened late August, and academic and industry researchers were allowed to debate and discuss oncolytic virology during the virus immunotherapy portion of the conference. The breakthrough agent, TVEC/IMLYGIC, as well as most other oncolytic viruses (OVs)
Paola Grandi, Cole Peters, Fares Nigim
openaire +4 more sources
Development and application of oncolytic viruses as the nemesis of tumor cells
Frontiers in Microbiology, 2023 Viruses and tumors are two pathologies that negatively impact human health, but what occurs when a virus encounters a tumor? A global consensus among cancer patients suggests that surgical resection, chemotherapy, radiotherapy, and other methods are the ...
Xiao Zhu +8 more
doaj +1 more source
Study of Oncolytic Virus Preservation and Formulation
Pharmaceuticals, 2023 In recent years, oncolytic viruses (OVs) have emerged as an effective means of treating cancer. OVs have multiple oncotherapeutic functions including specifically infecting and lysing tumor cells, initiating immune cell death, attacking and destroying tumor angiogenesis and triggering a broad bystander effect.
Lina Pan +6 more
openaire +3 more sources
Theranostic Potential of Oncolytic Vaccinia Virus [PDF]
Theranostics, 2012 Biological cancer therapies, such as oncolytic, or replication-selective viruses have advantages over traditional therapeutics as they can employ multiple different mechanisms to target and destroy cancers (including direct cell lysis, immune activation and vascular collapse). This has led to their rapid recent clinical development.
Steve H. Thorne, Juan J. Rojas
openaire +3 more sources