Results 31 to 40 of about 37,893 (278)
Enhancement of vaccinia virus based oncolysis with histone deacetylase inhibitors [PDF]
, 2010 Histone deacetylase inhibitors (HDI) dampen cellular innate immune response by decreasing interferon production and have been shown to increase the growth of vesicular stomatitis virus and HSV.
Atkins, H +15 more
core +1 more source
Molecular Therapy: Oncolytics, 2019 Vaccinia virus (VV) has been utilized in oncolytic virotherapy, but it risks a host antiviral immune response. VV has an extracellular enveloped virus (EEV) form consisting of a normal virion covered with a host-derived outer membrane that enables its ...
Motomu Nakatake +9 more
doaj +1 more source
Development and application of oncolytic viruses as the nemesis of tumor cells
Frontiers in Microbiology, 2023 Viruses and tumors are two pathologies that negatively impact human health, but what occurs when a virus encounters a tumor? A global consensus among cancer patients suggests that surgical resection, chemotherapy, radiotherapy, and other methods are the ...
Xiao Zhu +8 more
doaj +1 more source
The Oncolytic Virus in Cancer Diagnosis and Treatment
Frontiers in Oncology, 2020 Cancer has always been an enormous threat to human health and survival. Surgery, radiotherapy, and chemotherapy could improve the survival of cancer patients, but most patients with advanced cancer usually have a poor survival or could not afford the ...
Guo-dong Cao +9 more
doaj +1 more source
Molecular Therapy: Oncolytics, 2019 The efficacy of immune checkpoint blockade therapy against immunologically “cold” tumors can be enhanced by applying the checkpoint inhibitors in combination with oncolytic viruses.
Yujie Zhu +9 more
doaj +1 more source
Biological therapy in the treatment of melanoma [PDF]
, 2018 Melanoma is one of the most aggressive tumors and its incidence is on the rise. The low rates of survival in metastatic melanoma has led to the development of new drugs for this type of patient, such as biological therapy which has shown remarkable ...
Benea, Vasile +8 more
core +3 more sources
Oncolytic potency and reduced virus tumor-specificity in oncolytic virotherapy. A mathematical modelling approach. [PDF]
PLoS ONE, 2017 In the present paper, we address by means of mathematical modeling the following main question: How can oncolytic virus infection of some normal cells in the vicinity of tumor cells enhance oncolytic virotherapy?
Khaphetsi Joseph Mahasa +3 more
doaj +1 more source
Research progress of oncolytic virus combined with PD-1/PD-L1 inhibitors [PDF]
Jichu yixue yu linchuang, 2022 Oncolytic viruses are often used in combination with immune checkpoint inhibitors represented in two ways by programmed cell death 1/programmed cell death-Ligand 1 (PD-1/PD-L1).
GAN Zi-ying, TANG Hui
doaj +1 more source
Adaptation of transgene mRNA translation boosts the anticancer efficacy of oncolytic HSV1
Journal for ImmunoTherapy of Cancer, 2023 Background Transgenes deliver therapeutic payloads to improve oncolytic virus immunotherapy. Transgenes encoded within oncolytic viruses are designed to be highly transcribed, but protein synthesis is often negatively affected by viral infection ...
Huy-Dung Hoang +15 more
doaj +1 more source
Oncolytic herpes viruses, chemotherapeutics, and other cancer drugs [PDF]
, 2013 Oncolytic viruses are emerging as a potential new way of treating cancers. They are selectively replication-competent viruses that propagate only in actively dividing tumor cells but not in normal cells and, as a result, destroy the tumor cells by ...
Braidwood, L. +3 more
core +1 more source