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, 2023 Oncolytic viruses (OVs) are a class of viruses that can selectively replicate in and lyse cancer cells, and subsequent spread with a tumor while not causing damage to normal cells. Besides the direct oncolytic activity, OVs are also effective in stimulating the body immune responses which can further help recogonize, control or destroy cancer cells ...
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Oncolytic myxoma virus: The path to clinic [PDF]
Vaccine, 2013 Many common neoplasms are still noncurative with current standards of cancer therapy. More therapeutic modalities need to be developed to significantly prolong the lives of patients and eventually cure a wider spectrum of cancers. Oncolytic virotherapy is one of the promising new additions to clinical cancer therapeutics.
Masmudur M. Rahman +2 more
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Application progress of oncolytic virus combined with immunotherapy in the treatment of malignant tumors [PDF]
Zhongguo aizheng zazhiThe oncolytic virus (OV) therapy utilizes natural or genetically modified viruses to specifically target and infect tumor cells, leading to the destruction of cancer cells by the replication of the virus itself.
LIANG Yingyun, CHEN Jianhua
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Coxsackievirus B3—Its Potential as an Oncolytic Virus [PDF]
Viruses, 2021 Oncolytic virotherapy represents one of the most advanced strategies to treat otherwise untreatable types of cancer. Despite encouraging developments in recent years, the limited fraction of patients responding to therapy has demonstrated the need to search for new suitable viruses.
Anja Geisler +4 more
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Oncolytic potency and reduced virus tumor-specificity in oncolytic virotherapy. A mathematical modelling approach. [PDF]
PLoS ONE, 2017 In the present paper, we address by means of mathematical modeling the following main question: How can oncolytic virus infection of some normal cells in the vicinity of tumor cells enhance oncolytic virotherapy?
Khaphetsi Joseph Mahasa +3 more
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Immunotherapeutic potential of oncolytic vaccinia virus [PDF]
Immunologic Research, 2011 There has recently been resurgence in interest for the use of replication-selective (oncolytic) viruses for the treatment of cancers. This has been fueled by positive clinical data and the promise provided by next-generation vectors that are better targeted and display enhanced therapeutic potential.
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Journal of Translational Medicine, 2012 Oncolytic viruses refer to those that are able to eliminate malignancies by direct targeting and lysis of cancer cells, leaving non-cancerous tissues unharmed.
Patil Sandeep S +4 more
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Scientific Reports, 2021 Vaccination can prevent viral infections via virus-specific T cells, among other mechanisms. A goal of oncolytic virotherapy is replication of oncolytic viruses (OVs) in tumors, so pre-existing T cell immunity against an OV-encoded transgene would seem ...
Amanda W. K. AuYeung +8 more
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Molecular Therapy: Oncolytics, 2021 The oncolytic effect of virotherapy derives from the intrinsic capability of the applied virus in selectively infecting and killing tumor cells. Although oncolytic viruses of various constructions have been shown to efficiently infect and kill tumor ...
Divya Ravirala +3 more
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Measles virus: Background and oncolytic virotherapy
Biochemistry and Biophysics Reports, 2018 Measles is a highly transmissible disease caused by measles virus and remains a major cause of child mortality in developing countries. Measles virus nucleoprotein (N) encapsidates the RNA genome of the virus for providing protection from host cell endonucleases and for specific recognition of viral RNA as template for transcription and replication ...
Pramod Kumar Yadava +1 more
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