Results 51 to 60 of about 21,338 (215)

Systemic Delivery of Oncolytic Adenovirus to Tumors Using Tumor-Infiltrating Lymphocytes as Carriers

Cells, 2021
Immunotherapy with tumor-infiltrating lymphocytes (TIL) or oncolytic adenoviruses, have shown promising results in cancer treatment, when used as separate therapies.
Joao Santos, Camilla Heiniö, Dafne Quixabeira, Sadia Zafar, James Clubb, Santeri Pakola, Victor Cervera-Carrascon, Riikka Havunen, Anna Kanerva, Akseli Hemminki   +9 more
doaj   +1 more source

SOX10, MITF, and microRNAs: Decoding their interplay in regulating melanoma plasticity

International Journal of Cancer, EarlyView.
Abstract Recent studies show that the dysregulation of the transcription factor SOX10 is essential for the development and progression of melanoma. MicroRNAs (miRNAs) can regulate the expression of transcription factors at the post‐transcriptional level. The interactions between SOX10 and its targeting miRNAs form network motifs such as feedforward and
Xin Lai, Chunyan Luan, Zhesi Zhang, Anja Wessely, Markus V. Heppt, Carola Berking, Julio Vera   +6 more
wiley   +1 more source

Advanced single‐cell RNA sequencing in tumor immunology

Interdisciplinary Medicine, EarlyView.
This review highlights the applications of advanced single‐cell RNA sequencing (scRNA‐seq) technologies in tumor immunology. It summarizes representative scRNA‐seq methods according to technical principles, with a focus on single‐cell T cell receptor sequencing. This review also discusses how scRNA‐seq is used to construct immune cell atlases of tumors,
Yilong Liu, Xiyuan Yu, Zhipeng Han, Qiuyang Wei, Qi Niu, Chaoyong Yang, Jie P. Li, Zijian Guo, Huimin Zhang   +8 more
wiley   +1 more source

Oncolytic VSV-IL-2 has enhanced anticancer vaccination adjuvant abilities

Journal for ImmunoTherapy of Cancer
Background Heterologous oncolytic virus prime-boost vaccination is emerging as a promising cancer immunotherapy to establish potent antitumor immunity.
Marie-Claude Bourgeois-Daigneault, Victor Mullins-Dansereau, Marie-Lou Myre, Angelina Bardoul, Karen Geoffroy, Marco J Rallo Pita, Delphine Béland, Kim Leclerc Desaulniers, Dominic Guy Roy   +8 more
doaj   +1 more source

Targeting Tumor Vasculature With an Oncolytic Virus

Molecular Therapy, 2011
Oncolytic viruses (OVs) have been engineered or selected for cancer cell-specific infection however, we have found that following intravenous administration of vesicular stomatitis virus (VSV), tumor cell killing rapidly extends far beyond the initial sites of infection.
Aaron Fenster, Naomi De Silva, Harold L. Atkins, Kelley Parato, Manijeh Daneshmand, Yang Yang Sun, Caroline J. Breitbach, John C. Bell, Julia L Rintoul, Dominic G. Roy, David H. Kirn, Jennifer M Paterson, Brian D. Lichty, Laura Evgin, Theresa Falls, Marianne M. Stanford, Usaf E. Aladl   +16 more
openaire   +3 more sources

Inhibition of the mevalonate pathway enhances cancer cell oncolysis mediated by M1 virus

Nature Communications, 2018
Oncolytic viruses selectively kill tumour cells and induce anti-tumour immunity. Here, the AUs demonstrate the anti-viral effect of the mevalonate pathway on oncolytic virus M1 in refractory cancer cells and provide evidence for a combination strategy of
Jiankai Liang, Li Guo, Kai Li, Xiao Xiao, Wenbo Zhu, Xiaoke Zheng, Jun Hu, Haipeng Zhang, Jing Cai, Yaya Yu, Yaqian Tan, Chuntao Li, Xincheng Liu, Cheng Hu, Ying Liu, Pengxin Qiu, Xingwen Su, Songmin He, Yuan Lin, Guangmei Yan   +19 more
doaj   +1 more source

Initial dose of oncolytic myxoma virus programs durable antitumor immunity independent of in vivo viral replication

Journal for ImmunoTherapy of Cancer, 2020
Background Oncolytic therapy uses live-replicating viruses to improve the immunological status of treated tumors. Critically, while these viruses are known to self-amplify in vivo, clinical oncolytic therapies still appear to display a strong dose ...
Eric Bartee, Erica B Flores, Bulent A Aksoy   +2 more
doaj   +1 more source

Micro‐ and nanomotors in biomedical applications

Responsive Materials, EarlyView.
Micro‐ and nanomotors (MNMs), as autonomous devices converting chemical or external energy into mechanical propulsion, have emerged as transformative drug delivery platforms in biomedicine. This review systematically outlines the design principles governing MNMs' propulsion and operation, highlights the applications of MNMs in disease treatment, and ...
Xiangyu Meng, Yuqi Tang, Quan Li
wiley   +1 more source

Dependency of EGFR activation in vanadium-based sensitization to oncolytic virotherapy

Molecular Therapy: Oncolytics, 2022
Oncolytic virotherapy is a clinically validated approach to treat cancers such as melanoma; however, tumor resistance to virus makes its efficacy variable. Compounds such as sodium orthovanadate (vanadate) can overcome viral resistance and synergize with
Boaz Wong, Anabel Bergeron, Nouf Alluqmani, Glib Maznyi, Andrew Chen, Rozanne Arulanandam, Jean-Simon Diallo   +6 more
doaj  

The regulatory effects and applications of TIGIT/CD155 on the tumor microenvironment in HCC

VIEW, EarlyView.
Background The interaction between TIGIT and CD155 compromises immune cell efficacy in tumor targeting, potentially driving hepatocellular carcinoma (HCC) progression through diverse molecular pathways. What Was Done This study investigates the interplay between CD155 and TIGIT in regulating CD8+ T cell function and elucidates its implications in HCC ...
Wenting Li, Yukun Li, Yao Li, Mingqi Yang, Haichuan Peng, Hongwei Sun, Ping Jiang, Yizhun Zhu, Qiang Chen, Xiaobing Duan, Wei Zhao   +10 more
wiley   +1 more source