Wie sich das Herz erneuert : von Umprogrammierungen und Stammzellen [PDF]
, 2013 Erkrankungen des Herz-Kreislauf-Systems sind für die größte Zahl der Todesfälle in Deutschland verantwortlich. Das liegt nicht zuletzt daran, dass das menschliche Herz kaum Selbstheilungskräfte besitzt.
Braun, Thomas, Heil, Matthias
core
Loss of myocardial LIF receptor in experimental heart failure reduces cardiotrophin-1 cytoprotection. A role for neurohumoral agonists? [PDF]
, 2007 OBJECTIVES: Cardiomyocyte loss is involved in the transition from compensatory left ventricular hypertrophy (LVH) to heart failure (HF). Our aim was to investigate the status of the leukaemia inhibitory factor receptor (LIFR)/gp130 survival pathway and ...
Diez-Martinez, J. (Javier) +3 more
core +1 more source
Oncostatin M, an Underestimated Player in the Central Nervous System
Frontiers in Immunology, 2019 For a long time, the central nervous system (CNS) was believed to be an immune privileged organ. In the last decades, it became apparent that the immune system interacts with the CNS not only in pathological, but also in homeostatic situations. It is now
Evelien Houben +2 more
doaj +1 more source
Benefit of Apabetalone on Plasma Proteins in Renal Disease. [PDF]
, 2018 Introduction:Apabetalone, a small molecule inhibitor, targets epigenetic readers termed BET proteins that contribute to gene dysregulation in human disorders. Apabetalone has in vitro and in vivo anti-inflammatory and antiatherosclerotic properties.
Gilham, Dean +11 more
core +2 more sources
Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M
Nature Communications, 2018 The factors that mediate quiescence of muscle stem cells are unknown. The authors show that Oncostatin M is produced by skeletal muscle, suppresses stem cell proliferation, and that its deletion in muscle results in stem cell depletion and impaired ...
Srinath C. Sampath +9 more
doaj +1 more source
Chondroprotective Effect of Kartogenin on CD44-Mediated Functions in Articular Cartilage and Chondrocytes [PDF]
, 2014 OBJECTIVE: A recent report identified the small molecule kartogenin as a chondrogenic and chondroprotective agent. Since changes in hyaluronan metabolism occur during cartilage degeneration in osteoarthritis, we began studies to determine whether there ...
Haapala J +4 more
core +1 more source
Leptin signalling, obesity and prostate cancer: molecular and clinical perspective on the old dilemma [PDF]
, 2015 The prevalence of global obesity is increasing. Obesity is associated with general cancer-related morbidity and mortality and is a known risk factor for development of specific cancers.
Alfraidi, Albandri +5 more
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Serielle Genexpressionsanalyse der Neointimabildung nach Ballonangioplastie im humanen Organkulturmodell mittels DNA Array-Technologie: Neue Erkenntnisse zur Wirkung von Rapamycin [PDF]
, 2005 Hintergrund und Fragestellung Eines der schwerwiegenden Probleme der interventionellen Kardiologie stellte bislang die koronare Restenose im Stent dar.
Nührenberg, Thomas
core
Elevation of Plasma Oncostatin M in Heart Failure
Future Cardiology, 2017 Oncostatin M (OSM) is an inflammatory cytokine of the gp130 family. OSM could participate in adverse cardiovascular remodeling through regulation of FGF23.OSM levels were determined in 80 heart failure patients with reduced left ventricular ejection fraction (HFrEF).OSM levels are significantly increased in HFrEF patients compared with healthy subjects.
Gruson, Damien +3 more
openaire +3 more sources
Comparison of Oncostatin M in Patients with Chronic Periodontitis with and without Diabetes
Pesquisa Brasileira em Odontopediatria e Clínica Integrada, 2022 Objective: To compare the Oncostatin M (OSM) concentrations in tissues of patients with chronic periodontitis with and without diabetes. Material and Methods: Sixty-four subjects visiting the dental outpatient department were categorized as “healthy ...
Amulya Kolluri +4 more
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