Wie sich das Herz erneuert : von Umprogrammierungen und Stammzellen [PDF]
, 2013 Erkrankungen des Herz-Kreislauf-Systems sind für die größte Zahl der Todesfälle in Deutschland verantwortlich. Das liegt nicht zuletzt daran, dass das menschliche Herz kaum Selbstheilungskräfte besitzt.
Braun, Thomas, Heil, Matthias
core
Chondroprotective Effect of Kartogenin on CD44-Mediated Functions in Articular Cartilage and Chondrocytes [PDF]
, 2014 OBJECTIVE: A recent report identified the small molecule kartogenin as a chondrogenic and chondroprotective agent. Since changes in hyaluronan metabolism occur during cartilage degeneration in osteoarthritis, we began studies to determine whether there ...
Haapala J +4 more
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Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M
Nature Communications, 2018 The factors that mediate quiescence of muscle stem cells are unknown. The authors show that Oncostatin M is produced by skeletal muscle, suppresses stem cell proliferation, and that its deletion in muscle results in stem cell depletion and impaired ...
Srinath C. Sampath +9 more
doaj +1 more source
Oncostatin M, an Underestimated Player in the Central Nervous System
Frontiers in Immunology, 2019 For a long time, the central nervous system (CNS) was believed to be an immune privileged organ. In the last decades, it became apparent that the immune system interacts with the CNS not only in pathological, but also in homeostatic situations. It is now
Evelien Houben +2 more
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Benefit of Apabetalone on Plasma Proteins in Renal Disease. [PDF]
, 2018 Introduction:Apabetalone, a small molecule inhibitor, targets epigenetic readers termed BET proteins that contribute to gene dysregulation in human disorders. Apabetalone has in vitro and in vivo anti-inflammatory and antiatherosclerotic properties.
Gilham, Dean +11 more
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Administration of bone marrow derived mesenchymal stem cells into the liver: potential to rescue pseudoxanthoma elasticum in a mouse model (Abcc6-/-). [PDF]
, 2012 Pseudoxanthoma elasticum (PXE) is a heritable ectopic mineralization disorder caused by loss-of-function mutations in the ABCC6 gene which is primarily expressed in the liver. There is currently no effective treatment for PXE.
Jiang, Qiujie +2 more
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A Novel Oncostatin M-inducible Gene OIG37 Forms a Gene Family with MyD118 and GADD45 and Negatively Regulates Cell Growth [PDF]
, 1999 Koh Nakayama +4 more
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Inflammatory markers in prostate cancer: potential roles in risk stratification and immune profiling
Journal of ImmunotoxicologyInflammation plays a critical role in prostate cancer (PCa) pathophysiology, yet the diagnostic value of specific inflammatory markers remains unclear.
Edgaras Burzinskis +7 more
doaj +1 more source
Dectin-1 limits autoimmune neuroinflammation and promotes myeloid cell-astrocyte crosstalk via Card9-independent expression of Oncostatin M [PDF]
, 2021 M. Elizabeth Deerhake +8 more
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