Results 111 to 120 of about 19,011 (195)

Oncostatin M reverses ABCG2-mediated mitoxantrone resistance

Biomedicine & Pharmacotherapy
Mitoxantrone resistant variant of SW620 line was developed, characterized and subsequently used as a model system to determine oncostatin M ability to modulate MDR phenomenon. The selection regimen allowed for overexpression of ABCG2 and ABCB1 both at the RNA and protein level, which was further confirmed by functional assays.
Andrzej, Błauż, Marcin, Wachulec, Błażej, Rychlik   +2 more
openaire   +2 more sources

Inflammatory markers in prostate cancer: potential roles in risk stratification and immune profiling

Journal of Immunotoxicology
Inflammation plays a critical role in prostate cancer (PCa) pathophysiology, yet the diagnostic value of specific inflammatory markers remains unclear.
Edgaras Burzinskis, Ieva Janulaityte, Mindaugas Jievaltas, Darijus Skaudickas, Guoda Burzinskiene, Edvinas Dainius, Albinas Naudziunas, Astra Vitkauskiene   +7 more
doaj   +1 more source

Онкостатин и его роль в формировании сердечно-сосудистых заболеваний [PDF]

, 2014
Рассматриваются проблемы диагностической и прогности­ческой роли цитокинов семейства интерлейкина-6 и их участие в форми­ровании сердечно-сосудистых ...
Ковалева, О. Н., Кочубей, О. А.   +1 more
core   +1 more source

Single-cell sequencing combined with spatial transcriptomics reveals the characteristics of follicle-targeted inflammation patterns in primary cicatricial alopecia

Cell & Bioscience
Background Primary cicatricial alopecia (PCA) causes irreversible hair loss due to immune-mediated hair follicle destruction. This study investigates follicle-targeted inflammation in lichen planopilaris (LPP), a major PCA subtype, to identify ...
Qitao Chen, Yuqian Li, Qilin Zhu, Zhongming Li, Guanghui Shao, Yanjun Liu, Peixuan Jiang, Qiuwei Tao, Lili Shen, Jing Zhu, Linwei Wei, Yanhua Li, Xufeng Du   +12 more
doaj   +1 more source

Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage [PDF]

European Cells & Materials, 2011
The relative contribution of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)4 and ADAMTS5 to aggrecan degradation under oncostatin M (OSM) stimulation, the role of the ancillary domains of the aggrecanases on their ability to ...
M Durigova, L Troeberg, H Nagase, PJ Roughley, JS Mort   +4 more
doaj  

Oncostatin M: Foe or friend? [PDF]

Arthritis & Rheumatism, 2003
Jean-Pierre, Pelletier, Johanne, Martel-Pelletier   +1 more
openaire   +2 more sources

Oncostatin M/Oncostatin M Receptor Signal Induces Radiation-Induced Heart Fibrosis by Regulating SMAD4 in Fibroblast

International Journal of Radiation Oncology*Biology*Physics
Radiation-induced heart fibrosis (RIHF) is a severe consequence of radiation-induced heart damage (RIHD) leading to impaired cardiac function. The involvement of oncostatin M (OSM) and its receptor (OSMR) in RIHD remains unclear. This study aimed to investigate the specific mechanism of OSM/OSMR in RIHF/RIHD.RNA sequencing was performed on heart ...
Peng, Xu, Yali, Yi, Le, Xiong, Yuxi, Luo, Caifeng, Xie, Daya, Luo, Zhimin, Zeng, Anwen, Liu   +7 more
openaire   +2 more sources

Liver Capsule: Biliary Tree Stem Cell Subpopulations [PDF]

, 2016
ALVARO, Domenico, GAUDIO, EUGENIO
core   +1 more source

Dual Oncostatin M (OSM) Receptors [PDF]

Journal of Biological Chemistry, 1996
Bruce Mosley, Cyr De Imus, Della Friend, Norman Boiani, Bettina Thoma, Linda S. Park, David Cosman   +6 more
openaire   +1 more source

Suppression of gp130 attenuated insulin-mediated signaling and glucose uptake in skeletal muscle cells

Scientific Reports
The aim of the present study was to investigate the effects of Oncostatin M receptor (OSMR) subunit gp130 knockdown on insulin-stimulated glucose metabolism-related signaling pathways and glucose uptake in skeletal muscle cells.
Koji Sato
doaj   +1 more source