Results 41 to 50 of about 19,011 (195)

Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: implications in HIV-associated neurotoxicity [PDF]

, 2016
Background: Elevated levels of oncostatin M (OSM), an interleukin-6 cytokine family member, have been observed in HIV-1-associated neurocognitive disorders (HAND) and Alzheimer's disease.
David J. Volsky, Evelyn Wesseling, Hendrikus W. Boddeke, Marco Matos, Paula Agostinho, Rodrigo A. Cunha, Sabita Roy, Santanu Banerjee, Shamsudheen Moidunny   +8 more
core   +10 more sources

Amyloidosis cutis dyschromica in two female siblings: cases report [PDF]

, 2011
Background Cutaneous amyloidosis has been classified into primary cutaneous amyloidosis (PCA, OMIM #105250), secondary cutaneous amyloidosis and systemic cutaneous amyloidosis.
Wenlin Yang, Yangyang Lin, Jian Yang, Wensheng Lin   +3 more
core   +1 more source

Evaluating Serum Calprotectin and Serum Oncostatin M Levels as Diagnostic Markers in Crohn's Disease and Ulcerative Colitis Iraqi Patients. Research

Al-Mustansiriyah Journal of Pharmaceutical Sciences
Introduction: Inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), presents as chronic gastrointestinal inflammation. Timely diagnosis and effective monitoring are crucial for better outcomes.
Yahya G. Karwi, Inam S. Arif, Shaymaa A. Abdulameer   +2 more
doaj   +1 more source

miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer

Cell Reports, 2019
Summary: Genomic amplification of 3q26.2 locus leads to the increased expression of microRNA 551b-3p (miR551b-3p) in triple-negative breast cancer (TNBC).
Deepak Parashar, Anjali Geethadevi, Miriam Ragle Aure, Jyotsna Mishra, Jasmine George, Changliang Chen, Manoj K. Mishra, Andliena Tahiri, Wei Zhao, Bindu Nair, Yiling Lu, Lingegowda S. Mangala, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Amadou K.S. Camara, Mingyu Liang, Janet S. Rader, Ramani Ramchandran, Ming You, Anil K. Sood, Vessela N. Kristensen, Gordon B. Mills, Sunila Pradeep, Pradeep Chaluvally-Raghavan   +23 more
doaj   +1 more source

Cardiac oxidative stress and inflammatory cytokines response after myocardial infarction [PDF]

, 2015
Oxidative stress in heart failure or during ischemia/reperfusion occurs as a result of the excessive generation or accumulation of free radicals or their oxidation products.
Cerretani D., Di Paolo M, Fineschi V, Neri M, Pomara C, Riezzo I, Turillazzi E   +6 more
core   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Expression of oncostatin M in hematopoietic organs [PDF]

Developmental Dynamics, 2002
AbstractMurine oncostatin M (OSM), a member of the interleukin‐6 (IL‐6) ‐related cytokine subfamily, stimulates definitive hematopoiesis and liver development. The OSM gene was cloned as a cytokine‐inducible early response gene in some hematopoietic cell lines.
Shinobu, Tamura, Yoshihiro, Morikawa, Atsushi, Miyajima, Emiko, Senba   +3 more
openaire   +2 more sources

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis

Advanced Science, EarlyView.
Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang, Yuchen Wang, Binbin Li, Xin Li, Chenyu Liu, Yanhao Chen, Cheng Tian, Dongmei Wang, Xiaosong Gu, Chunping Jiang, Yuda Wei, Qiurong Ding   +11 more
wiley   +1 more source

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

OSMR controls glioma stem cell respiration and confers resistance of glioblastoma to ionizing radiation

Nature Communications, 2020
The suppression of the receptor for oncostatin M (OSMR) can prevent glioblastoma cell growth. Here, the authors demonstrate a role for OSMR in modulating glioma stem cell respiration and its impact on resistance to ionizing radiation.
Ahmad Sharanek, Audrey Burban, Matthew Laaper, Emilie Heckel, Jean-Sebastien Joyal, Vahab D. Soleimani, Arezu Jahani-Asl   +6 more
doaj   +1 more source