Results 51 to 60 of about 19,011 (195)
Oncostatin M suppresses browning of white adipocytes via gp130-STAT3 signaling
Molecular Metabolism, 2021 Objective: Obesity is associated with low-grade adipose tissue inflammation and locally elevated levels of several glycoprotein 130 (gp130) cytokines.
Pim P. van Krieken +5 more
doaj +1 more source
Chondrocyte responses to neurovascular peptides, cytokines, and a 3D environment: focus on ADAMs [PDF]
, 2016 Chondrocyte exposure to inflammatory stimuli in several arthritic conditions, including osteoarthritis, results in the well-characterised induction of extracellular matrix (ECM) degrading proteinases, notably members of a disintegrin and ...
Baker, N +4 more
core +2 more sources
Gene expression patterns following unilateral traumatic brain injury reveals a local pro-inflammatory and remote anti-inflammatory response. [PDF]
, 2013 BackgroundTraumatic brain injury (TBI) results in irreversible damage at the site of impact and initiates cellular and molecular processes that lead to secondary neural injury in the surrounding tissue.
Ford, Byron D +5 more
core +2 more sources
Oncostatin M and its role in fibrosis [PDF]
Connective Tissue Research, 2018 Oncostain M, a member of the IL-6 family of cytokines, is produced by immune cells in response to infections and tissue injury. OSM has a broad, often context-dependent effect on various cellular processes including differentiation, hematopoiesis, cell proliferation, and cell survival.
Lukasz, Stawski, Maria, Trojanowska
openaire +2 more sources
Journal of Pediatric Gastroenterology and Nutrition, EarlyView.Abstract Objectives Eosinophilic esophagitis (EoE) is characterized by eosinophilic inflammation and epithelial remodeling. However, current biomarkers focus predominantly on eosinophilia, overlooking basal cell hyperplasia (BCH), a histologic feature that may persist despite treatment.
Adi Eindor‐Abarbanel +7 more
wiley +1 more source
Oncostatin M Confers Neuroprotection against Ischemic Stroke [PDF]
Journal of Neuroscience, 2015 Cell-surface receptors provide potential targets for the translation of bench-side findings into therapeutic strategies; however, this approach for the treatment of stroke is disappointing, at least partially due to an incomplete understanding of the targeted factors.
Sen, Guo +11 more
openaire +2 more sources
Harnessing energy metabolism for enhanced bone defect repair: Mechanisms and therapeutic strategies
VIEW, EarlyView.This review addresses the critical challenge of bone defect repair by focusing on the underexplored role of cellular energy metabolism. It synthesizes regulatory mechanisms in bone‐forming cells and sums up innovative strategies—leveraging cell derivatives, active factors, and biomimetic scaffolds—to modulate metabolism for enhanced regeneration.
Junting Li +5 more
wiley +1 more source
Frontiers in Molecular Biosciences, 2020 Therapeutics targeting cytokines such as the oncostatin M (OSM)-mediated inflammation represent a potential strategy for the treatment of inflammatory bowel disease (IBD). Despite the investigation of the specific role of the interactions between OSM and
Qingqing Du, Yan Qian, Weiwei Xue
doaj +1 more source
Generation of Induced Cardiospheres via Reprogramming of Skin Fibroblasts for Myocardial Regeneration [PDF]
, 2016 © 2016 The Authors STEM CELLS published by Wiley Periodicals, Inc. on behalf of AlphaMed PressRecent pre-clinical and clinical studies have suggested that endogenous cardiospheres (eCS) are potentially safe and effective for cardiac regeneration ...
Beltrami +44 more
core +1 more source
Cell Proliferation, EarlyView.Microporous array organ chips were integrated with commercially available well plates to develop organoid chip platforms, which enable modelling of hepatic physiology and non‐alcoholic fatty liver disease (NAFLD) pathogenesis, as well as evaluation of semaglutide therapeutics. ABSTRACT Progressive non‐alcoholic fatty liver disease (NAFLD) may culminate
Xiao‐yan You +3 more
wiley +1 more source