Results 71 to 80 of about 12,338 (205)

Mechanism of oncostatin M in microenvironment regulation and metastasis of breast cancer [PDF]

Yixue xinzhi zazhi
This paper explores the multiple roles of oncostatin M (OSM) in the breast cancer microenvironment. OSM enhances invasion and metastasis of breast cancer cells by activating the JAK/STAT pathway, promoting epithelial-mesenchymal transition, cancer ...
CHEN Wangcheng, PANG Lili, LAN Yuemei, ZHANG Baihong   +3 more
doaj   +1 more source

Oncostatin M receptor regulates osteoblast differentiation via extracellular signal-regulated kinase/autophagy signaling

Stem Cell Research & Therapy, 2022
Background Oncostatin M receptor (OSMR), as one of the receptors for oncostatin M (OSM), has previously been shown to mediate the stimulatory role of OSM in osteoclastogenesis and bone resorption.
Jie Zhou, Junying Yang, Yuan Dong, Yaru Shi, Endong Zhu, Hairui Yuan, Xiaoxia Li, Baoli Wang   +7 more
doaj   +1 more source

Oestrogen receptor phosphorylation profiles and in silico PAM50 subtyping reflect sexual dimorphism in breast cancer

The Journal of Pathology: Clinical Research, Volume 12, Issue 4, July 2026.
Abstract Breast cancer (BC) is most prevalent in females but also accounts for <1% of male cancer cases and 0.2% of male cancer‐related deaths. Distribution of histological subtypes, receptor status, and age of diagnosis varies based on sex, and a growing body of evidence supports sex‐specific molecular differences in BC.
Subarnarekha Chatterji, Aimee Diack, Marcin Szostok, Michael D Morgan, Valentina Silvestri, Laura Ottini, Cathy B Moelans, Paul J van Diest, Cigdem Selli, Andrew H Sims, Rasha Abu‐Eid, Valerie Speirs   +11 more
wiley   +1 more source

Calcification and tumour‐infiltrating lymphocytes predict upgrade of human epidermal growth factor 2 (HER2)‐negative ductal carcinoma in situ diagnosed on core needle biopsy

Histopathology, Volume 89, Issue 1, Page 122-135, July 2026.
With evolving paradigm in treatment of patient diagnosed with pure ductal carcinoma in situ (DCIS), it is essential to stratify patients at low risk for upgrade to invasive disease at subsequent excision to inform management decisions. When combined with adequate sampling and intrinsic tumour characteristics, tumour microenvironment (TME) features ...
Monalyn Marabi, Yuyang Li, Chaiwat Aphivatanasiri, Julia Y Tsang, Joshua JX Li, Lin‐Ying Chen, Gary M Tse   +6 more
wiley   +1 more source

Oncostatin M Plays a Critical Role in Survival after Acute Intestinal Ischemia: Reperfusion Injury

, 2020
Background: Acute intestinal ischemia-reperfusion injury (AIIRI) is a devastating clinical condition relevant to multiple diseases processes, including sepsis, trauma, transplantation, and burns.
Mueller, Thomas F, Young, Pang Y, Thomas A. Churchill, Thomas F. Mueller, Rachel G. Khadaroo, Sis, Banu, Khadaroo, Rachel G, Churchill, Thomas A, Banu Sis, Pang Y. Young   +9 more
core   +1 more source

Itch intensity in prurigo nodularis is closely related to dermal interleukin‐31, oncostatin M, IL‐31 receptor alpha and oncostatin M receptor beta

, 2021
Prurigo nodularis (PN) is a chronic skin dermatosis with hyperkeratotic and intensely pruritic nodules. Managing PN-associated itch is difficult because its aetiology is still unknown.
Leigh A. Nattkemper, Sonali Nanda, Fayne, Rachel A, Serena M. Shah, Romanelli, Paolo, Kursewicz, Christina D, Paolini, John F, Paolo Romanelli, Gil Yosipovitch, Nanda, Sonali, Nattkemper, Leigh A, Hei Sung Kim, Emilie Fowler, Hashimoto, Takashi, Kim, Hei Sung, Shah, Serena M, John F. Paolini, Fowler, Emilie, Takashi Hashimoto, Christina D. Kursewicz, Rachel A. Fayne, Yosipovitch, Gil   +21 more
core   +1 more source

The Nuclear Protein HOXB13 Enhances Methylmercury Toxicity by Inducing Oncostatin M and Promoting Its Binding to TNFR3 in Cultured Cells

Cells, 2019
Homeobox protein B13 (HOXB13), a transcription factor, is related to methylmercury toxicity; however, the downstream factors involved in enhancing methylmercury toxicity remain unknown.
Takashi Toyama, Sidi Xu, Ryo Nakano, Takashi Hasegawa, Naoki Endo, Tsutomu Takahashi, Jin-Yong Lee, Akira Naganuma, Gi-Wook Hwang   +8 more
doaj   +1 more source

The Complex Relation of Branched‐Chain Amino Acids and Inflammation in the Obesity and Diabetes Context

Obesity Reviews, Volume 27, Issue 7, July 2026.
ABSTRACT In a scenario with increasing cases of obesity and diabetes worldwide, branched‐chain amino acids (BCAA) metabolism has become an important factor in the understanding of these pathologies. More recently, its chronic high plasma levels have been postulated, alongside glucose, inflammatory factors, and other molecules, as an important ...
Bernardo Starling‐Soares, Monique Macedo Coelho, Bruna Guerra Campolina, Camila Kümmel Duarte, Tatiani Uceli Maioli   +4 more
wiley   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, Volume 13, Issue 32, 9 June 2026.
Itch‐induced tick removal (IITR): An acquired neuroimmune mechanism, itch‐induced tick removal, develops after repeated tick exposure, mobilizing T cells and macrophages at the tick bite site to trigger a rapid scratching response that facilitates timely tick removal within a critical window that precedes the transmission of many tick‐borne pathogens ...
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

PhD

, 2008
dissertationCytokines comprise the molecular communication networks that allow cells to respond to their environments. Oncostatin M belongs to the interleukin-6 family of cytokines and has diverse effects on many different cell types.
Dahms, Kimberly Mae.
core