Results 61 to 70 of about 19,011 (195)

Expression of nephronectin is inhibited by oncostatin M via both JAK/STAT and MAPK pathways

FEBS Open Bio, 2015
Nephronectin (Npnt), also called POEM, is an extracellular matrix protein considered to play critical roles as an adhesion molecule in the development and functions of various tissues, such as the kidneys, liver, and bones.
Tamaki Kurosawa, Atsushi Yamada, Masamichi Takami, Dai Suzuki, Yoshiro Saito, Katsuhiro Hiranuma, Takuya Enomoto, Naoko Morimura, Matsuo Yamamoto, Takehiko Iijima, Tatsuo Shirota, Hiroyuki Itabe, Ryutaro Kamijo   +12 more
doaj   +1 more source

Hyperbaric oxygen suppresses stemness-associated properties and Nanog and oncostatin M expression, but upregulates -catenin in orthotopic glioma models

Journal of International Medical Research, 2020
Objective This study aimed to explore whether initial hyperbaric oxygen treatment affects the stemness of glioma stem cells using an in vivo basal ganglia glioma model. Methods A basal ganglia glioma rat model was established. Rats were exposed to normal
Kun Song, Junrui Chen, Jianbo Ding, Hao Xu, Hongzhi Xu, Zhiyong Qin   +5 more
doaj   +1 more source

Involution of the mouse mammary gland is associated with an immune cascade and an acute-phase response, involving LBP, CD14 and STAT3 [PDF]

, 2004
INTRODUCTION: Involution of the mammary gland is a complex process of controlled apoptosis and tissue remodelling. The aim of the project was to identify genes that are specifically involved in this process.
Bell, A.K., Davies, C.R., Duffy, M.A., Ferrier, R.K., Gusterson, B.A., Heath, V.J., Morris, J.S., Sandilands, G.P., Stein, T., Weber-Hall, S.J.   +9 more
core  

Global Transcriptomic Profiling of Bovine Endometrial Immune Response In Vitro. II. Effect of Bovine Viral Diarrhea Virus on the Endometrial Response to Lipopolysaccharide [PDF]

, 2015
Infection with noncytopathic bovine viral diarrhea virus (ncpBVDV) is associated with uterine disease and infertility. This study investigated the influence of ncpBVDV on immune functions of the bovine endometrium by testing the response to bacterial ...
Abudureyimu, A, Anstaett, O L, Brownlie, J, Cheng, Z R, Fouladi-Nashta, A A, Oguejiofor, C F, Wathes, D C   +6 more
core   +2 more sources

Signaling of Type II Oncostatin M Receptor [PDF]

Journal of Biological Chemistry, 1997
Oncostatin M (OSM) mediates its bioactivities through two different heterodimer receptors. They both involve the gp130-transducing receptor, which dimerizes with either leukemia inhibitory receptor beta or with OSM receptor beta (OSMRbeta) to generate, respectively, type I and type II OSM receptors.
P, Auguste, C, Guillet, M, Fourcin, C, Olivier, J, Veziers, A, Pouplard-Barthelaix, H, Gascan   +6 more
openaire   +2 more sources

Safety and efficacy of nemolizumab for atopic dermatitis up to 2 years in open‐label extension study

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This study evaluated long‐term safety and efficacy in patients with moderate‐to‐severe atopic dermatitis. Patients with and without previous nemolizumab experience received nemolizumab 30 mg Q4W plus TCS/TCI. Nemolizumab was well‐tolerated through 104 weeks with clinically meaningful improvements in disease signs and symptoms.
Matthias Augustin, Marie Tauber, Robert Sidbury, Jonathan I. Silverberg, Kim A. Papp, Diamant Thaçi, Marjolein S. De Bruin‐Weller, Adam Reich, Ketty Peris, Kirk Barber, Ryszard Galus, Andrzej Kaszuba, Matthew Zirwas, Walter K. Nahm, Gretel Trullenque, Laura Maintz, Sady Alpizar, Sang Wook Son, Vivian Laquer, Linda Stein Gold, Soo Yeon Cheong, Anna Ryzhkova, Agnes Drahos, Liliana Ulianov, Christophe Piketty   +24 more
wiley   +1 more source

Oncostatin M [OSM] protein immuno-expression in oral squamous cell carcinoma – A prospective study

Oral Oncology Reports
Background: An important factor in the progression of tumours is the formation of blood vessels in the tumour stroma. When there is an upregulation of angiogenesis stimulators or a downregulation of angiogenesis inhibitors, the tumour may manifest its ...
Sunil Prakash, Nandhini Gunasekaran, Ramya Mahalingam, Rajkumar Krishnan   +3 more
doaj   +1 more source

Regulation of IL-33 by Oncostatin M in Mouse Lung Epithelial Cells

Mediators of Inflammation, 2016
IL-33 modulates both innate and adaptive immune responses at tissue sites including lung and may play critical roles in inflammatory lung disease.
Carl D. Richards, Laura Izakelian, Anisha Dubey, Grace Zhang, Steven Wong, Karen Kwofie, Aatif Qureshi, Fernando Botelho   +7 more
doaj   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

A key role for leukemia inhibitory factor in C26 cancer cachexia [PDF]

, 2015
Cachexia is an exacerbating event in many types of cancer that is strongly associated with a poor prognosis. We have identified cytokine, signaling, and transcription factors that are required for cachexia in the mouse C26 colon carcinoma model of cancer.
Jackman, Robert W., Kandarian, Susan C., Seto, Danielle N.   +2 more
core   +1 more source