Results 51 to 60 of about 341,624 (160)

Association Between Dietary Intake of One-Carbon Metabolism-Related Nutrients and Fluorosis in Guizhou, China

Frontiers in Nutrition, 2021
Objective: This study aimed to investigate the associations between dietary one-carbon metabolism-related nutrients (betaine, choline, methionine, folate, vitamin B6, and vitamin B12) and fluorosis among the Chinese population in an area known for coal ...
Ting Chen, Na Tao, Sheng Yang, Dafang Cao, Xun Zhao, Donghong Wang, Jun Liu   +6 more
doaj   +1 more source

Formate Reduces Ischemic Injury in Female Hearts Lacking Alcohol Dehydrogenase 5

FASEB BioAdvances
Ischemic heart disease is a primary cause of death for men and women in the United States. Recent epidemiologic findings, however, suggest that premenopausal women have inherent protection from many cardiovascular pathologies compared to age‐matched men,
Haley Garbus‐Grant, Obialunanma V. Ebenebe‐Kasonde, Raihan Kabir, Mark J. Kohr   +3 more
doaj   +1 more source

Pathway analysis of genetic variants in folate‐mediated one‐carbon metabolism‐related genes and survival in a prospectively followed cohort of colorectal cancer patients

Cancer Medicine, 2018
Folate‐mediated one‐carbon metabolism (FOCM) is a key pathway essential for nucleotide synthesis, DNA methylation, and repair. This pathway is a critical target for 5‐fluorouracil (5‐FU), which is predominantly used for colorectal cancer (CRC) treatment.
Jennifer Ose, Akke Botma, Yesilda Balavarca, Katharina Buck, Dominique Scherer, Nina Habermann, Jolantha Beyerle, Katrin Pfütze, Petra Seibold, Elisabeth J. Kap, Axel Benner, Lina Jansen, Katja Butterbach, Michael Hoffmeister, Hermann Brenner, Alexis Ulrich, Martin Schneider, Jenny Chang‐Claude, Barbara Burwinkel, Cornelia M. Ulrich   +19 more
doaj   +1 more source

Targeting SHMTs and MTHFDs in cancer: attractive opportunity for anti-tumor strategy

Frontiers in Pharmacology
One-carbon metabolism is a universal metabolic process that mediates the transfer of one-carbon units for purine and thymidine synthesis. One-carbon metabolism has been found to be dysregulated in various cancer types due to its role in production of ...
Xue Zhang, Zhenhua Wang
doaj   +1 more source

Engineering Plant One-Carbon Metabolism [PDF]

, 2005
Primary and secondary metabolism intersect in the one-carbon (C1) area. Primary metabolism supplies most of the C1 units and competes with secondary metabolism for their use. This competition is potentially severe because secondary products such as lignin, alkaloids, and glycine betaine (GlyBet) require massive amounts of C1 units.
openaire   +2 more sources

Hypermethylated Colorectal Cancer Tumours Present a Myc-Driven Hypermetabolism with a One-Carbon Signature Associated with Worsen Prognosis

Biomedicines
Colorectal cancer (CRC) is the second cause of cancer-related death; the CpG-island methylation pathway (CIMP) is associated with KRAS/BRAF mutations, two oncogenes rewiring cell metabolism, worse prognosis, and resistance to classical chemotherapies ...
Christophe Desterke, Fanny Jaulin, Emmanuel Dornier   +2 more
doaj   +1 more source

Plant one-carbon metabolism and its engineering

Trends in Plant Science, 2000
The metabolism of one-carbon (C1) units is vital to plants. It involves unique enzymes and takes place in four subcellular compartments. Plant C1 biochemistry has remained relatively unexplored, partly because of the low abundance or the lability of many of its enzymes and intermediates.
Horticultural Sciences Dept, University of Florida, Gainesville, FL 32611-0690, USA ( host institution ), Hanson, Andrew D., Gage, Douglas A., Shachar-Hill, Yair   +3 more
openaire   +3 more sources

Effects of feeding two rumen-protected choline sources during the transition period on performance and blood metabolites of Holstein dairy cows

Italian Journal of Animal Science
This study evaluated the effects of two rumen-protected choline (RPC) sources supplemented to dairy cows from 21 d pre- to 35 d postpartum. Twenty-four multiparous Holstein cows were randomly assigned to three groups (n = 8/group): control (CON ...
V. Sáinz de la Maza-Escolà, F. Piccioli-Cappelli, L. Cattaneo, L. Benedetti, A. Piva, E. Grilli, E. Trevisi   +6 more
doaj   +1 more source

Association Between SNPs in the One-Carbon Metabolism Pathway and the Risk of Female Breast Cancer in a Chinese Population

Pharmacogenomics and Personalized Medicine, 2022
Xuhong Wang,1,2,* Mengqiu Xiong,2,* Bei Pan,1,2 William CS Cho,3 Jin Zhou,4 Shukui Wang,1,2,5 Bangshun He2,5 1School of Medicine, Southeast University, Nanjing, Jiangsu Province, 210096, People’s Republic of China; 2Department of Laboratory ...
Wang X, Xiong M, Pan B, Cho WC, Zhou J, Wang S, He B   +6 more
doaj  

Beyond the Warburg Effect: How Do Cancer Cells Regulate One-Carbon Metabolism?

Frontiers in Cell and Developmental Biology, 2018
Altered metabolism in cancer cells is critical for tumor growth. One of the most notable aspects of this metabolic reprogramming lies in one-carbon metabolism.
Adam Rosenzweig, Adam Rosenzweig, John Blenis, John Blenis, Ana P. Gomes, Ana P. Gomes   +5 more
doaj   +1 more source