Results 91 to 100 of about 20,326,114 (289)

Targeting SHMTs and MTHFDs in cancer: attractive opportunity for anti-tumor strategy

Frontiers in Pharmacology
One-carbon metabolism is a universal metabolic process that mediates the transfer of one-carbon units for purine and thymidine synthesis. One-carbon metabolism has been found to be dysregulated in various cancer types due to its role in production of ...
Xue Zhang, Zhenhua Wang
doaj   +1 more source

Genetic associations with plasma B12, B6, and folate levels in an ischemic stroke population from the Vitamin Intervention for Stroke Prevention (VISP) trial

Frontiers in Public Health, 2014
B vitamins play an important role in homocysteine metabolism, with vitamin deficiencies resulting in increased levels of homocysteine and increased risk for stroke.
Keith L Keene, Keith L Keene, Wei-Min eChen, Wei-Min eChen, Fang eChen, Stephen Richardson Williams, Stacey D Elkhatib, Fang-Chi eHsu, Josyf C Mychaleckyj, Josyf C Mychaleckyj, Kimberley F Doheny, Elizabeth W Pugh, Hua eLing, Cathy C Laurie, Stephanie M Gogarten, Ebony B Madden, Bradford B Worrall, Bradford B Worrall, Michele M Sale, Michele M Sale, Michele M Sale   +20 more
doaj   +1 more source

Genotype frequencies of one-carbon metabolism-related gene polymorphisms between controls and RIF patients.

, 2016
Genotype frequencies of one-carbon metabolism-related gene polymorphisms between controls and RIF patients.
Sung Han Shim (141576), Jung Jae Ko (765713), Ji Hyang Kim (555698), Woo Sik Lee (837218), Youngsok Choi (216009), Yubin Lee (3080403), Young Joo Jeon (128378), Nam Keun Kim (128410), Jung Oh Kim (765714)   +8 more
core   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Alcohol Exposure May Increase Prenatal Choline Needs Through Redirection of Choline into Lipid Synthesis Rather than Methyl Donation

Metabolites
Background: Prenatal alcohol exposure (PAE) can reduce fetal growth and cause neurodevelopmental disability. Prenatal choline supplements attenuate PAE-induced behavioral and growth deficits; however, the underlying mechanisms are unknown. Alcohol alters
Hannah G. Petry, Nipun Saini, Susan M. Smith, Sandra M. Mooney   +3 more
doaj   +1 more source

Virus-mediated hijack of one-carbon metabolism [PDF]

Nature Reviews Cancer, 2019
Wang et al. investigated the early metabolic changes associated with Epstein–Barr virus (EBV) infection of B cells, which may have implications for EBV-driven lymphomas.
openaire   +2 more sources

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Hypermethylated Colorectal Cancer Tumours Present a Myc-Driven Hypermetabolism with a One-Carbon Signature Associated with Worsen Prognosis

Biomedicines
Colorectal cancer (CRC) is the second cause of cancer-related death; the CpG-island methylation pathway (CIMP) is associated with KRAS/BRAF mutations, two oncogenes rewiring cell metabolism, worse prognosis, and resistance to classical chemotherapies ...
Christophe Desterke, Fanny Jaulin, Emmanuel Dornier   +2 more
doaj   +1 more source

Pathways of Methionine Biosynthesis and One-Carbon Metabolism in E. coli

, 2013
Pathways of Methionine Biosynthesis and One-Carbon Metabolism in E ...
Elise R Hondorp (57008), Rowena G Matthews (57009)   +1 more
core   +1 more source