Patients’ experiences treated with open-label placebo versus double-blind placebo: a mixed methods qualitative study [PDF]
BMC Psychology, 2022 Background There is increasing evidence suggesting that open-label placebo (OLP) is an effective treatment for several medical conditions defined by self-report.
Julia W. Haas +9 more
doaj +7 more sources
Can the Open Label Placebo Rationale Be Optimized? [PDF]
Frontiers in Pain Research, 2021 Uwe Heiss +2 more
doaj +5 more sources
Can observational learning reinforce open-label placebo hypoalgesia? [PDF]
Pain, 2023 Previous research has indicated that an open-label placebo can reduce pain in both healthy participants and chronic pain patients. As nondeceptive placebos seem to be an effective and more ethical alternative to deceptive placebos, optimizing this kind of treatment is essential.
Brączyk J, Bąbel P.
europepmc +4 more sources
Evidencing general acceptability of open-label placebo use for tackling overtreatment in primary care: a mixed methods study [PDF]
BMC Medicine, 2023 Background Overtreatment poses a challenge to healthcare systems due to harmful consequences of avoidable side-effects and costs. This study presents the first account for examining the feasibility of placebo use for reducing overtreatment in primary ...
E. M. Krockow +4 more
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A randomized controlled trial of effects of open-label placebo compared to double-blind placebo and treatment-as-usual on symptoms of allergic rhinitis [PDF]
Scientific Reports, 2023 Placebo effects are known for numerous clinical symptoms. Until recently, deception of placebos was thought to be essential for placebo effects, but intriguing new studies suggest that even placebos without concealment (open-label placebos) may help ...
Michael Schaefer +2 more
doaj +2 more sources
Neural underpinnings of open-label placebo effects in emotional distress. [PDF]
Neuropsychopharmacology, 2023 AbstractWhile placebo effects are well-known, research in the last decade revealed intriguing effects that placebos may have beneficial effects even when given without deception. At first glance, this seems paradoxical, but several studies have reported improvements in pain, depression, or anxiety.
Schaefer M +4 more
europepmc +3 more sources
Placebo Effects of Open-label Verbal Suggestions on Itch [PDF]
Acta Dermato-Venereologica, 2017 Placebo effects are positive outcomes that are not due to active treatment components, which may be elicited even when patients are aware of receiving an inert substance (open-label).
Stefanie H. Meeuwis +6 more
doaj +6 more sources
Do cognitive bias and heuristics influence improvement in knee pain in patients with knee osteoarthritis treated with open label placebo? The CHIPS study - An exploratory study using questionnaire and group concept mapping [PDF]
Osteoarthritis and Cartilage OpenObjective: This study explored if the patient-experience and the affect heuristic influenced improvements in painful symptoms, in response to open label placebo injections in patients with knee OA.
Tommy Kok Annfeldt +5 more
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"Let's see what happens:"-Women's experiences of open-label placebo treatment for menopausal hot flushes in a randomized controlled trial. [PDF]
PLoS ONE, 2022 Open-label (honestly prescribed) placebos are an ethical way to evoke placebo effects in patients. As part of a mixed-methods study, we conducted in-depth interviews with eight menopausal women who underwent and benefitted from open-label placebo ...
Yiqi Pan +3 more
doaj +2 more sources
Open-label placebos as adjunctive therapy for patients with depression
Contemporary Clinical Trials Communications, 2022 Background: Placebos prescribed as ‘regular’ medication can reduce symptoms of depression. However, using a placebo without patients' informed consent presents ethical issues.
Anne Schienle, Nina Jurinec
doaj +3 more sources