Results 21 to 30 of about 402,459 (240)

White man’s disease, black man’s peril?: Rinderpest and famine in the eastern Bechuanaland Protectorate at the end of the 19th century

open access: yesContree, 2014
During the late nineteenth century, a pandemic of Rinderpest exterminated large numbers of cattle in Southern Africa. Although in the Bechuanaland Protectorate the disease killed cattle only for two years between 1896 and 1897, its effects were to last ...
Phuthego P. Molosiwa
doaj   +1 more source

Self-devised assistive techniques by university students with learning disabilities

open access: yesAfrican Journal of Disability, 2023
Background: Access to assistive technology for disabilities is limited in low-resource settings. Therefore, existing research focuses on accessibility challenges.
Ndakaitei Manase
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Enhancing professional self-esteem: learners' journeys on a distance-learning Doctorate in Education (EdD) [PDF]

open access: yes, 2009
This article explores the motivations, experiences and perceived outcomes for Doctorate in Education (EdD) students in their journey through a relatively new form of doctoral education at a distance.
Sieminski, Sandy, Butcher, John
core   +1 more source

Trust in AI: scale development and validation for online distance learners

open access: yesBMC Psychology
Trust in artificial intelligence (AI) has emerged as a critical factor influencing students’ interactions with AI-supported learning environments. However, validated instruments for measuring student trust in AI within educational contexts remain limited.
Ayşin Gaye Üstün   +5 more
doaj   +1 more source

The extent of and reasons for non re-enrolment: A case of Korea National Open University

open access: yesInternational Review of Research in Open and Distributed Learning, 2013
Despite continuous efforts to increase retention, dropout rates are high in distance universities. The objectives of this study were: 1) to investigate the extent and causes of non re-enrollment at a mega university, Korea National Open University; and 2)
Hyoseon Choi   +3 more
doaj   +1 more source

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

A Collaborative Approach to OER Policy and Guidelines Development in the Commonwealth: The Case of Botswana, Cameroon, and Sri Lanka

open access: yesInternational Review of Research in Open and Distributed Learning, 2018
Access to relevant learning resources is an important aspect in ensuring inclusive and equitable quality education and lifelong learning opportunities for all as outlined in the sustainable development goal 4 (SDG4).
Ishan Sudeera Abeywardena   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

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