Results 51 to 60 of about 284,682 (289)

Dissecting the binding mechanisms of transcription factors to DNA using a statistical thermodynamics framework

Computational and Structural Biotechnology Journal, 2020
Transcription Factors (TFs) bind to DNA and control activity of target genes. Here, we present ChIPanalyser, a user-friendly, versatile and powerful R/Bioconductor package predicting and modelling the binding of TFs to DNA.
Patrick C.N. Martin, Nicolae Radu Zabet
doaj   +1 more source

Histone crosstalk directed by H2B ubiquitination is required for chromatin boundary integrity [PDF]

, 2011
Genomic maps of chromatin modifications have provided evidence for the partitioning of genomes into domains of distinct chromatin states, which assist coordinated gene regulation.
West, A., Ma, M.K-W., Adam G West, Heath, C., Carol Heath, Adam G. West, Meiji Kit-Wan Ma, Hair, A., Alan Hair   +8 more
core   +1 more source

Chromatin Accessibility Impacts Transcriptional Reprogramming in Oocytes

Cell Reports, 2018
Summary: Oocytes have a remarkable ability to reactivate silenced genes in somatic cells. However, it is not clear how the chromatin architecture of somatic cells affects this transcriptional reprogramming.
Kei Miyamoto, Khoi T. Nguyen, George E. Allen, Jerome Jullien, Dinesh Kumar, Tomoki Otani, Charles R. Bradshaw, Frederick J. Livesey, Manolis Kellis, John B. Gurdon   +9 more
doaj   +1 more source

Chromatin accessibility dynamics of Chlamydia-infected epithelial cells. [PDF]

, 2020
Chlamydia are Gram-negative, obligate intracellular bacterial pathogens responsible for a broad spectrum of human and animal diseases. In humans, Chlamydia trachomatis is the most prevalent bacterial sexually transmitted infection worldwide and is the ...
Hayward RJ, Marsh JW, Humphrys MS, Myers GSA, Huston WM   +4 more
core   +1 more source

OCEAN-C: mapping hubs of open chromatin interactions across the genome reveals gene regulatory networks

Genome Biology, 2018
We develop a method called open chromatin enrichment and network Hi-C (OCEAN-C) for antibody-independent mapping of global open chromatin interactions. By integrating FAIRE-seq and Hi-C, OCEAN-C detects open chromatin interactions enriched by active cis ...
Tingting Li, Lumeng Jia, Yong Cao, Qing Chen, Cheng Li   +4 more
doaj   +1 more source

Genome-wide MNase hypersensitivity assay unveils distinct classes of open chromatin associated with H3K27me3 and DNA methylation in Arabidopsis thaliana

Genome Biology, 2020
Background Regulation of transcription depends on interactions between cis-regulatory elements (CREs) and regulatory proteins. Active CREs are imbedded in open chromatin that are accessible to nucleases.
Hainan Zhao, Wenli Zhang, Tao Zhang, Yuan Lin, Yaodong Hu, Chao Fang, Jiming Jiang   +6 more
doaj   +1 more source

Do LCRs Open Chromatin Domains? [PDF]

Cell, 1998
One could argue that the natural location of a gene cluster has evolved to provide the optimal environment for its expression so why should elements exist to ensure that it is correctly expressed elsewhere? Now that homologous recombination can be performed efficiently in mammalian cells, regulatory elements will more frequently be analyzed in situ ...
openaire   +2 more sources

Analysis of β-globin chromatin micro-environment using a novel 3C variant, 4Cv [PDF]

, 2010
Copyright: © 2010 Pink et al.Higher order chromatin folding is critical to a number of developmental processes, including the regulation of gene expression.
Christopher H Eskiw, Christopher H. Eskiw, David R F Carter, Eskiw, CH, Daniel P Caley, Pink Ryan C., David R. F. Carter, Caley, DP, Ryan C Pink, Caley, D, Carter, D, Daniel P. Caley, Eskiw Christopher H., Caley Daniel P., Pink, R, Ryan C. Pink, Eskiw, C, Carter David R. F.   +17 more
core   +1 more source

HiCoP, a simple and robust method for detecting interactions of regulatory regions

Epigenetics & Chromatin, 2020
Background Chromatin physical interactions provide essential information for understanding the regulation of cis-elements like enhancers, promoters, and insulators in cell development and differentiation. The Hi-C assay is a technique detecting chromatin
Yan Zhang, Zhaoqiang Li, Shasha Bian, Hao Zhao, Delong Feng, Yanhong Chen, Yuhe Hou, Qifa Liu, Bingtao Hao   +8 more
doaj   +1 more source

Multi-omics integration identifies NK cell-mediated cytotoxicity as a therapeutic target in systemic lupus erythematosus

Frontiers in Immunology
BackgroundSystemic lupus erythematosus (SLE) is an autoimmune condition that impacts various organs. Given the intricate clinical progression of SLE, it is imperative to explore novel avenues for precise diagnosis and treatment.MethodsPeripheral blood ...
Jingjing Zhang, Ling Ma, Hanyin Deng, Wenqian Yi, Alim Tohtihan, Xiaojun Tang, Xiudi Wu, Xuebing Feng   +7 more
doaj   +1 more source