Results 41 to 50 of about 284,682 (289)

The Proportion of Chromatin Graded between Closed and Open States Determines the Level of Transcripts Derived from Distinct Promoters in the CYP19 Gene. [PDF]

PLoS ONE, 2015
The human CYP19 gene encodes aromatase, which converts androgens to estrogens. CYP19 mRNA variants are transcribed mainly from three promoters. Quantitative RT-PCR was used to measure the relative amounts of each of the three transcripts and determine ...
Naoe Kotomura, Nobuhiro Harada, Satoru Ishihara   +2 more
doaj   +1 more source

Extracting physical characteristics of higher-order chromatin structures from 3D image data

Computational and Structural Biotechnology Journal, 2022
Higher-order chromatin structures have functional impacts on gene regulation and cell identity determination. Using high-throughput sequencing (HTS)-based methods like Hi-C, active or inactive compartments and open or closed topologically associating ...
William Franz Lamberti, Chongzhi Zang
doaj   +1 more source

Quantitative analysis of chromatin compaction in living cells using FLIM-FRET [PDF]

, 2009
We present a quantitative Forster resonance energy transfer (FRET)-based assay using multiphoton fluorescence lifetime imaging microscopy (FLIM) to measure chromatin compaction at the scale of nucleosomal arrays in live cells. The assay uses a human cell
Angus I. Lamond, Norman, David G., James, John, Lleres, David, Lamond, Angus, I, John James, David Llères, Swift, Sam, David G. Norman, Norman, David, G, Lamond, Angus I.; id_orcid, Sam Swift   +11 more
core   +1 more source

Detecting Differential Transcription Factor Activity from ATAC-Seq Data

Molecules, 2018
Transcription factors are managers of the cellular factory, and key components to many diseases. Many non-coding single nucleotide polymorphisms affect transcription factors, either by directly altering the protein or its functional activity at ...
Ignacio J. Tripodi, Mary A. Allen, Robin D. Dowell   +2 more
doaj   +1 more source

Epigenetic modifications unlock the milk protein gene loci during mouse mammary gland development and differentiation. [PDF]

PLoS ONE, 2013
Unlike other tissues, development and differentiation of the mammary gland occur mostly after birth. The roles of systemic hormones and local growth factors important for this development and functional differentiation are well-studied. In other tissues,
Monique Rijnkels, Courtneay Freeman-Zadrowski, Joseph Hernandez, Vani Potluri, Liguo Wang, Wei Li, Danielle G Lemay   +6 more
doaj   +1 more source

Repressive and non-repressive chromatin at native telomeres in Saccharomyces cerevisiae [PDF]

, 2009
Background In Saccharomyces cerevisiae genes that are located close to a telomere can become transcriptionally repressed by an epigenetic process known as telomere position effect.
Esther R Loney, Pryde, Fiona E., Louis Edward J, Pryde, FE, F. E. Pryde (7675940), Mellor, J., P. W. Inglis (7675937), Nicholas A Kent, J. Mellor (27566), Pryde Fiona E, Mellor Jane, Sharp Sarah, Kent Nicholas A, Loney, E. R., Sharp, Sarah, Sharp, S., Edward John Louis (7604981), Sharp, S, Kent, NA, S. Sharp (7639394), Inglis, Peter W., Louis, Edward J., Inglis, P. W., Inglis, PW, N. A. Kent (7675943), Peter W Inglis, Loney, Esther R., Kent, Nicholas A., Jane Mellor, Mellor, J, Edward J Louis, Pryde, F. E., Louis, E. J., Loney Esther R, Inglis Peter W, Loney, ER, Louis, EJ, E. R. Loney (7675934), Mellor, Jane, Fiona E Pryde, Sarah Sharp   +40 more
core   +1 more source

Mapping and Dynamics of Regulatory DNA in Maturing Arabidopsis thaliana Siliques

Frontiers in Plant Science, 2019
The genome is reprogrammed during development to produce diverse cell types, largely through altered expression and activity of key transcription factors.
Alessandra M. Sullivan, Andrej A. Arsovski, Agnieszka Thompson, Richard Sandstrom, Robert E. Thurman, Shane Neph, Audra K. Johnson, Shawn T. Sullivan, Peter J. Sabo, Fidencio V. Neri, Molly Weaver, Morgan Diegel, Jennifer L. Nemhauser, John A. Stamatoyannopoulos, Kerry L. Bubb, Christine Queitsch   +15 more
doaj   +1 more source

Live-cell imaging of chromatin contacts opens a new window into chromatin dynamics

Epigenetics & Chromatin, 2023
AbstractOur understanding of the organization of the chromatin fiber within the cell nucleus has made great progress in the last few years. High-resolution techniques based on next-generation sequencing as well as optical imaging that can investigate chromatin conformations down to the single cell level have revealed that chromatin structure is highly ...
van Staalduinen, Jente, van Staveren, Thomas, Grosveld, Frank, Wendt, Kerstin S.   +3 more
openaire   +4 more sources

Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation [PDF]

, 2010
Background: Brahma-related gene 1 (Brg1, also known as Smarca4 and Snf2 beta) encodes an adenosine-5'-triphosphate (ATP)-dependent catalytical subunit of the (switch/sucrose nonfermentable) (SWI/SNF) chromatin remodeling complexes.
He, Shuying, Metzger, Daniel, Wolf Louise, Bharesh K Chauhan, Chambon, Pierre, Ruth Ashery-Padan, Nakai, Akira, Zavadil, Jiri, Cveklova Kveta, Daniel Metzger, Ernst R Tamm, Chauhan Bharesh K, Metzger Daniel, Melinda K Pirity, Wang Wei-Lin, Chauhan, Bharesh K., Pierre Chambon, Cveklova, Kveta, Cvekl Ales, Akira Nakai, Ales Cvekl, Pirity Melinda K, Wolf, Louise, Tamm, Ernst R., Ashery-Padan, Ruth, Cvekl, Ales, Chambon Pierre, Wang, Wei-Lin, Wei-Lin Wang, Ashery-Padan Ruth, Nakai Akira, He Shuying, Shuying He, Kveta Cveklova, Zavadil Jiri, Louise Wolf, Tamm Ernst R, Jiri Zavadil, Pirity, Melinda K.   +38 more
core   +1 more source

Open chromatin

, 2023
Open chromatin regions of 17 human normal ...
Yan (16909524)
core   +1 more source