Results 21 to 30 of about 408,119 (206)
The Proportion of Chromatin Graded between Closed and Open States Determines the Level of Transcripts Derived from Distinct Promoters in the CYP19 Gene. [PDF]
PLoS ONE, 2015 The human CYP19 gene encodes aromatase, which converts androgens to estrogens. CYP19 mRNA variants are transcribed mainly from three promoters. Quantitative RT-PCR was used to measure the relative amounts of each of the three transcripts and determine ...
Naoe Kotomura +2 more
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Extracting physical characteristics of higher-order chromatin structures from 3D image data
Computational and Structural Biotechnology Journal, 2022 Higher-order chromatin structures have functional impacts on gene regulation and cell identity determination. Using high-throughput sequencing (HTS)-based methods like Hi-C, active or inactive compartments and open or closed topologically associating ...
William Franz Lamberti, Chongzhi Zang
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Detecting Differential Transcription Factor Activity from ATAC-Seq Data
Molecules, 2018 Transcription factors are managers of the cellular factory, and key components to many diseases. Many non-coding single nucleotide polymorphisms affect transcription factors, either by directly altering the protein or its functional activity at ...
Ignacio J. Tripodi +2 more
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Mapping and Dynamics of Regulatory DNA in Maturing Arabidopsis thaliana Siliques
Frontiers in Plant Science, 2019 The genome is reprogrammed during development to produce diverse cell types, largely through altered expression and activity of key transcription factors.
Alessandra M. Sullivan +15 more
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Epigenetic modifications unlock the milk protein gene loci during mouse mammary gland development and differentiation. [PDF]
PLoS ONE, 2013 Unlike other tissues, development and differentiation of the mammary gland occur mostly after birth. The roles of systemic hormones and local growth factors important for this development and functional differentiation are well-studied. In other tissues,
Monique Rijnkels +6 more
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Chromatin Accessibility Impacts Transcriptional Reprogramming in Oocytes
Cell Reports, 2018 Summary: Oocytes have a remarkable ability to reactivate silenced genes in somatic cells. However, it is not clear how the chromatin architecture of somatic cells affects this transcriptional reprogramming.
Kei Miyamoto +9 more
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Computational and Structural Biotechnology Journal, 2020 Transcription Factors (TFs) bind to DNA and control activity of target genes. Here, we present ChIPanalyser, a user-friendly, versatile and powerful R/Bioconductor package predicting and modelling the binding of TFs to DNA.
Patrick C.N. Martin, Nicolae Radu Zabet
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Genome Biology, 2018 We develop a method called open chromatin enrichment and network Hi-C (OCEAN-C) for antibody-independent mapping of global open chromatin interactions. By integrating FAIRE-seq and Hi-C, OCEAN-C detects open chromatin interactions enriched by active cis ...
Tingting Li +4 more
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Genome Biology, 2020 Background Regulation of transcription depends on interactions between cis-regulatory elements (CREs) and regulatory proteins. Active CREs are imbedded in open chromatin that are accessible to nucleases.
Hainan Zhao +6 more
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Genetic landscape of open chromatin in yeast. [PDF]
PLoS Genetics, 2013 Chromatin regulation underlies a variety of DNA metabolism processes, including transcription, recombination, repair, and replication. To perform a quantitative genetic analysis of chromatin accessibility, we obtained open chromatin profiles across 96 ...
Kibaick Lee +10 more
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