Results 31 to 40 of about 284,682 (289)
Molecular Cell, 2002 How the transcriptional apparatus gains access to and subsequently opens compacted chromatin has remained a mystery. Now in this issue of Molecular Cell, Zaret and coworkers show that chromatin opening in vitro is not mediated by the classical chromatin remodeling machines but instead occurs through specific transcription factor-histone interactions.
Lomvardas, Stavros, Thanos, Dimitris
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, 2020 Spermatogenesis requires radical restructuring of germline chromatin at multiple stages, involving coordinated waves of DNA methylation/demethylation, histone modification, and the replacement and removal that occurs before, during, and after meiosis ...
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Proteomic interrogation of human chromatin. [PDF]
, 2011 Chromatin proteins provide a scaffold for DNA packaging and a basis for epigenetic regulation and genomic maintenance. Despite understanding its functional roles, mapping the chromatin proteome (i.e. the "Chromatome") is still a continuing process. Here,
LeRoy, Gary +22 more
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Dynamics of subnuclear chromatin organization during "C. elegans" development : a role for H3K9 methylation [PDF]
, 2012 In eukaryotic cells, DNA is packaged into chromatin. This imposes an accessibility barrier to all genetic processes, while at the same time offering the means for tight control.
Towbin, Benjamin Daniel
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Dynamic chromatin: concerted nucleosome remodelling and acetylation [PDF]
, 2005 The flexibility of chromatin that enables translation of environmental cues into changes in genome utilisation, relies on a battery of enzymes able to modulate chromatin structure in a highly targeted and regulated manner.
Eberharter, Anton +2 more
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Discovery of transcription factors and regulatory regions driving in vivo tumor development by ATAC-seq and FAIRE-seq open chromatin profiling. [PDF]
PLoS Genetics, 2015 Genomic enhancers regulate spatio-temporal gene expression by recruiting specific combinations of transcription factors (TFs). When TFs are bound to active regulatory regions, they displace canonical nucleosomes, making these regions biochemically ...
Kristofer Davie +6 more
doaj +1 more source
Identification and validation of transcription factors that regulate chromatin dynamics [PDF]
, 2012 Gene expression has to be tightly regulated during all cellular processes. During embryonic development differentiating cells loose their developmental potential and acquire specific functions by activating lineage-specific genes.
Schöler, Anne
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Cas9 Functionally Opens Chromatin
PLOS ONE, 2016 Using a nuclease-dead Cas9 mutant, we show that Cas9 reproducibly induces chromatin accessibility at previously inaccessible genomic loci. Cas9 chromatin opening is sufficient to enable adjacent binding and transcriptional activation by the settler transcription factor retinoic acid receptor at previously unbound motifs.
Barkal, Amira A. +4 more
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Chromatin immunoprecipitation and an open chromatin assay in zebrafish erythrocytes [PDF]
, 2016 Zebrafish is an excellent genetic and developmental model for the study of vertebrate development and disease. Its ability to produce an abundance of transparent, externally developed embryos has facilitated large-scale genetic and chemical screens for the identification of critical genes and chemical factors that modulate developmental pathways. These
S, Yang +5 more
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The Adenomatous Polyposis Coli protein contributes to normal compaction of mitotic chromatin [PDF]
, 2012 The tumour suppressor <i>Adenomatous Polyposis Coli</i> (APC) is required for proper mitosis; however, the exact role of APC in mitosis is not understood.
Newton, Ian P. +44 more
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