Results 11 to 20 of about 408,119 (206)

HiCAR is a robust and sensitive method to analyze open-chromatin-associated genome organization. [PDF]

Mol Cell, 2022
Wei X, Xiang Y, Peters DT, Marius C, Sun T, Shan R, Ou J, Lin X, Yue F, Li W, Southerland KW, Diao Y.   +11 more
europepmc   +2 more sources

ISDH-seq: a robust methodology for profiling and characterization of open chromatin. [PDF]

Plant Biotechnol J
Li Z, Run Y, Yang Y, Shi Y, Tavakoli M, Peng Y, She L, Borovskii G, Zhang W.   +8 more
europepmc   +2 more sources

Altered and allele-specific open chromatin landscape reveals epigenetic and genetic regulators of innate immunity in COVID-19. [PDF]

Cell Genom, 2023
Zhang B, Zhang Z, Koeken VACM, Kumar S, Aillaud M, Tsay HC, Liu Z, Kraft ARM, Soon CF, Odak I, Bošnjak B, Vlot A, Deutsche COVID-19 OMICS Initiative (DeCOI), Swertz MA, Ohler U, Geffers R, Illig T, Huehn J, Saliba AE, Sander LE, Förster R, Xu CJ, Cornberg M, Schulte LN, Li Y.   +24 more
europepmc   +2 more sources

Epigenetic signals that direct cell type–specific interferon beta response in mouse cells

Life Science Alliance, 2023
Preexisting cell type–specific chromatin features represent an additional regulatory layer for interferon beta response and direct binding of STAT transcription factors and gene induction. The antiviral response induced by type I interferon (IFN) via the
Markus Muckenhuber, Isabelle Seufert, Katharina Müller-Ott, Jan-Philipp Mallm, Lara C Klett, Caroline Knotz, Jana Hechler, Nick Kepper, Fabian Erdel, Karsten Rippe   +9 more
doaj   +1 more source

Dznep, a histone modification inhibitor, inhibits HIF1α binding to TIMP2 gene and suppresses TIMP2 expression under hypoxia

Physiological Reports, 2023
Epidemiological studies have shown that patients who recovered from acute kidney injury (AKI) may subsequently develop chronic kidney disease (CKD). AKI is primarily caused by renal hypoxia, and it causes epigenetic alterations, known as hypoxic memory ...
Tomotaka Yamazaki, Imari Mimura, Yu Kurata, Tetsuhiro Tanaka, Masaomi Nangaku   +4 more
doaj   +1 more source

Bibliometric Analysis of ATAC-Seq and Its Use in Cancer Biology via Nucleic Acid Detection

Frontiers in Medicine, 2020
Assay for transposase-accessible chromatin using sequencing (ATAC-seq) is associated with significant progress in biological research and has attracted increasing attention.
Yu Zhao, Xianwen Zhang, Zhenhua Song, Danian Wei, Hong Wang, Hong Wang, Wei Chen, Guodong Sun, Weiying Ma, Kebing Chen   +9 more
doaj   +1 more source

Improving Chromatin-Interaction Prediction Using Single-Cell Open-Chromatin Profiles and Making Insight Into the Cis-Regulatory Landscape of the Human Brain

Frontiers in Genetics, 2021
Single-cell open-chromatin profiles have the potential to reveal the pattern of chromatin-interaction in a cell type. However, currently available cis-regulatory network prediction methods using single-cell open-chromatin profiles focus more on local ...
Neetesh Pandey, Omkar Chandra, Shreya Mishra, Vibhor Kumar   +3 more
doaj   +1 more source

Chromatin interaction neural network (ChINN): a machine learning-based method for predicting chromatin interactions from DNA sequences

Genome Biology, 2021
Chromatin interactions play important roles in regulating gene expression. However, the availability of genome-wide chromatin interaction data is limited.
Fan Cao, Yu Zhang, Yichao Cai, Sambhavi Animesh, Ying Zhang, Semih Can Akincilar, Yan Ping Loh, Xinya Li, Wee Joo Chng, Vinay Tergaonkar, Chee Keong Kwoh, Melissa J. Fullwood   +11 more
doaj   +1 more source

Enrichment analysis of Alu elements with different spatial chromatin proximity in the human genome

Protein & Cell, 2016
Transposable elements (TEs) have no longer been totally considered as “junk DNA” for quite a time since the continual discoveries of their multifunctional roles in eukaryote genomes.
Zhuoya Gu, Ke Jin, M. James C. Crabbe, Yang Zhang, Xiaolin Liu, Yanyan Huang, Mengyi Hua, Peng Nan, Zhaolei Zhang, Yang Zhong   +9 more
doaj   +1 more source

Discovery of transcription factors and regulatory regions driving in vivo tumor development by ATAC-seq and FAIRE-seq open chromatin profiling. [PDF]

PLoS Genetics, 2015
Genomic enhancers regulate spatio-temporal gene expression by recruiting specific combinations of transcription factors (TFs). When TFs are bound to active regulatory regions, they displace canonical nucleosomes, making these regions biochemically ...
Kristofer Davie, Jelle Jacobs, Mardelle Atkins, Delphine Potier, Valerie Christiaens, Georg Halder, Stein Aerts   +6 more
doaj   +1 more source