Results 81 to 90 of about 1,168,745 (259)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Analysis of ICT Competencies Among Distance Learning Students in selected Study Centres of the National Open University of Nigeria

Journal of Learning for Development, 2020
The research evaluated the ICT competencies of Distance learning students of the National Open University of Nigeria, as a pre-requisite for their effectiveness in a computer-based learning environment.
Clifford Moses Amini, Oluwaseun Oluyide
doaj  

Learning to cope with an open world [PDF]

Artificial Intelligence for Engineering Design, Analysis and Manufacturing, 1996
Science has developed detailed and well-founded theories for analyzing the behavior of artifacts. For example, Boeing was able to correctly verify an entirely new airplane, the Boeing 777, before any prototype was even built. However, there are few theories, and no computer systems, that would allow us to design structures with a similar degree of ...
openaire   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

From coping to hoping: Reclaiming meaningful learning relationships in Second Chance Schools operating in Greek prisons

Formare
This paper explores the role of education within Greek prisons – spaces marked by overcrowding, poor living conditions, and scarce opportunities for meaningful engagement.
Antigone K. Efstratoglou, George Koulaouzides   +1 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Interdisciplinary collaboration for open research: reflections by Graduate Engagement Leads

Insights: The UKSG Journal
This case study provides an in-role reflection by the Graduate Engagement Leads for Open Research at the University of York. It uses the methodologies of reflection in practice and reflection-on-the-future to explore the challenges, such as gaps in ...
Katie Vernon, Yorgos Paschos, Luqman Muraina   +2 more
doaj   +1 more source