Posttranscriptional Regulation by Copper with a New Upstream Open Reading Frame [PDF]
mBio, 2022 Copper is essential to most living beings but also highly toxic and as such is an important player at the host-pathogen interface. Bacteria have thus developed homeostatic mechanisms to tightly control its intracellular concentration. Known Cu export and
Gauthier Roy +6 more
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Triple Intergenotype Recombination of Human Astrovirus 5, Human Astrovirus 8, and Human Astrovirus 1 in the Open Reading Frame 1a, Open Reading Frame 1b, and Open Reading Frame 2 Regions of the Human Astrovirus Genome [PDF]
Microbiology Spectrum, 2023 Human astrovirus (HAstV) strains exhibit high levels of genetic diversity, and many recombinant strains with different recombination patterns have been reported. The aims of the present study were to investigate the emergence of HAstV recombinant strains
Hongyu Wei +9 more
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Proteoforms expand the world of microproteins and short open reading frame-encoded peptides [PDF]
iScience, 2023 Summary: Microproteins and short open reading frame-encoded peptides (SEPs) can, like all proteins, carry numerous posttranslational modifications. Together with posttranscriptional processes, this leads to a high number of possible distinct protein ...
Liam Cassidy +2 more
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A positive-sense single-stranded RNA virus acquired a negative-sense open reading frame through recombination. [PDF]
PLoS PathogensAlthough positive- and negative-sense single-stranded RNA viruses are ubiquitous in nature, there is currently no evidence of recombination or reassortment between viruses with these two major forms of genome organization. Here, we describe the discovery
Xuan Dong +15 more
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Translational control of murine adiponectin expression by an upstream open reading frame element [PDF]
RNA Biology, 2023 Adiponectin, an adipocyte-specific secretory protein encoded by the ADIPOQ gene has a causal role in insulin resistance. Anti-diabetic drugs increase plasma adiponectin by a poorly understood, post-transcriptional mechanism enhancing insulin sensitivity.
Kommireddy Vasu +6 more
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Mitochondrial-Encoded Peptide MOTS-c, Diabetes, and Aging-Related Diseases [PDF]
Diabetes & Metabolism Journal, 2023 Mitochondria are complex metabolic organelles with manifold pathophysiological implications in diabetes. Currently published mitochondrial-encoded peptides, which are expressed from the mitochondrial open reading frame of the 12S ribosomal RNA type-c ...
Byung Soo Kong +2 more
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Association of chromosome 6 open reading frame 106 in different cancers
Frontiers in Bioscience-Landmark, 2021 Introduction: Cancer is the leading cause of death globally according to WHO in 2020. It is initiated by genetic mutations that occur due to numerous factors.
Emad Kutbi +3 more
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RNA elements in open reading frames of the bluetongue virus genome are essential for virus replication. [PDF]
PLoS ONE, 2014 Members of the Reoviridae family are non-enveloped multi-layered viruses with a double stranded RNA genome consisting of 9 to 12 genome segments. Bluetongue virus is the prototype orbivirus (family Reoviridae, genus Orbivirus), causing disease in ...
Femke Feenstra +3 more
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Deletion of Dystrophin In-Frame Exon 5 Leads to a Severe Phenotype: Guidance for Exon Skipping Strategies. [PDF]
PLoS ONE, 2016 Duchenne and Becker muscular dystrophy severity depends upon the nature and location of the DMD gene lesion and generally correlates with the dystrophin open reading frame.
Zhi Yon Charles Toh +7 more
doaj +1 more source
An upstream open reading frame regulates LST1 expression during monocyte differentiation. [PDF]
PLoS ONE, 2014 The regulation of gene expression depends on the interplay of multiple factors at the transcriptional and translational level. Upstream open reading frames (uORFs) play an important role as translational repressors of main ORFs and their presence or ...
Christian Schiller +4 more
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