Triple Intergenotype Recombination of Human Astrovirus 5, Human Astrovirus 8, and Human Astrovirus 1 in the Open Reading Frame 1a, Open Reading Frame 1b, and Open Reading Frame 2 Regions of the Human Astrovirus Genome [PDF]
Microbiology Spectrum, 2023 Human astrovirus (HAstV) strains exhibit high levels of genetic diversity, and many recombinant strains with different recombination patterns have been reported. The aims of the present study were to investigate the emergence of HAstV recombinant strains
Hongyu Wei +9 more
doaj +2 more sources
Association of chromosome 6 open reading frame 106 in different cancers [PDF]
Frontiers in Bioscience-Landmark, 2021 Introduction: Cancer is the leading cause of death globally according to WHO in 2020. It is initiated by genetic mutations that occur due to numerous factors.
Emad Kutbi +3 more
doaj +2 more sources
Posttranscriptional Regulation by Copper with a New Upstream Open Reading Frame
mBio, 2022 Copper is essential to most living beings but also highly toxic and as such is an important player at the host-pathogen interface. Bacteria have thus developed homeostatic mechanisms to tightly control its intracellular concentration. Known Cu export and
Gauthier Roy +6 more
doaj +2 more sources
Transcriptome analysis of
Parasites & Vectors, 2009 Background Human infection by the pork tapeworm Taenia solium affects more than 50 million people worldwide, particularly in underdeveloped and developing countries. Cysticercosis which arises from larval encystation can be life threatening and difficult
Tyler Kevin M +15 more
doaj +5 more sources
Open Reading Frame Phylogenetic Analysis on the Cloud [PDF]
International Journal of Genomics, 2013 Phylogenetic analysis has become essential in researching the evolutionary relationships between viruses. These relationships are depicted on phylogenetic trees, in which viruses are grouped based on sequence similarity.
Che-Lun Hung, Chun-Yuan Lin
doaj +3 more sources
Translation Initiation from Conserved Non-AUG Codons Provides Additional Layers of Regulation and Coding Capacity [PDF]
mBio, 2017 Neurospora crassa cpc-1 and Saccharomyces cerevisiae GCN4 are homologs specifying transcription activators that drive the transcriptional response to amino acid limitation.
Ivaylo P. Ivanov +11 more
doaj +4 more sources
Evolutionary Conservation of the PA-X Open Reading Frame in Segment 3 of Influenza A Virus [PDF]
, 2012 PA-X is a fusion protein of influenza A virus encoded in part from a +1 frameshifted X open reading frame (X-ORF) in segment 3. We show that the X-ORFs of diverse influenza A viruses can be divided into two groups that differ in selection pressure and ...
Digard, Paul +5 more
core +3 more sources
C12orf5 (chromosome 12 open reading frame 5) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2018 Review on C12orf5, with data on DNA/RNA, on the protein encoded and where the gene is ...
Bartrons Bach, Ramon +5 more
core +5 more sources
A positive-sense single-stranded RNA virus acquired a negative-sense open reading frame through recombination. [PDF]
PLoS PathogensAlthough positive- and negative-sense single-stranded RNA viruses are ubiquitous in nature, there is currently no evidence of recombination or reassortment between viruses with these two major forms of genome organization. Here, we describe the discovery
Xuan Dong +15 more
doaj +2 more sources
Translational control of murine adiponectin expression by an upstream open reading frame element [PDF]
RNA Biology, 2023 Adiponectin, an adipocyte-specific secretory protein encoded by the ADIPOQ gene has a causal role in insulin resistance. Anti-diabetic drugs increase plasma adiponectin by a poorly understood, post-transcriptional mechanism enhancing insulin sensitivity.
Kommireddy Vasu +6 more
doaj +2 more sources