Open Reading Frame Phylogenetic Analysis on the Cloud [PDF]
International Journal of Genomics, 2013 Phylogenetic analysis has become essential in researching the evolutionary relationships between viruses. These relationships are depicted on phylogenetic trees, in which viruses are grouped based on sequence similarity.
Che-Lun Hung, Chun-Yuan Lin
doaj +5 more sources
Posttranscriptional Regulation by Copper with a New Upstream Open Reading Frame [PDF]
mBio, 2022 Copper is essential to most living beings but also highly toxic and as such is an important player at the host-pathogen interface. Bacteria have thus developed homeostatic mechanisms to tightly control its intracellular concentration. Known Cu export and
Gauthier Roy +6 more
doaj +5 more sources
Triple Intergenotype Recombination of Human Astrovirus 5, Human Astrovirus 8, and Human Astrovirus 1 in the Open Reading Frame 1a, Open Reading Frame 1b, and Open Reading Frame 2 Regions of the Human Astrovirus Genome [PDF]
Microbiology Spectrum, 2023 Human astrovirus (HAstV) strains exhibit high levels of genetic diversity, and many recombinant strains with different recombination patterns have been reported. The aims of the present study were to investigate the emergence of HAstV recombinant strains
Hongyu Wei +9 more
doaj +2 more sources
Nature Communications, 2019 The majority of enterovirus proteins are encoded as polyprotein in one open reading frame. Here, Guo et al. characterize a second open reading frame in human enteroviruses and show that it is important for viral particle release, particularly in ...
Haoran Guo +9 more
doaj +2 more sources
Characterization of a second open reading frame in genome segment 10 of bluetongue virus [PDF]
Journal of General Virology, 2015 Viruses have often evolved overlapping reading frames in order to maximize their coding capacity. Until recently, the segmented dsRNA genome of viruses of the Orbivirus genus was thought to be monocistronic, but the identification of the bluetongue virus
Meredith E. Stewart +11 more
semanticscholar +4 more sources
Transcriptome analysis of
Parasites & Vectors, 2009 Background Human infection by the pork tapeworm Taenia solium affects more than 50 million people worldwide, particularly in underdeveloped and developing countries. Cysticercosis which arises from larval encystation can be life threatening and difficult
Tyler Kevin M +15 more
doaj +5 more sources
A Novel Mutation in the Upstream Open Reading Frame of the CDKN1B Gene Causes a MEN4 Phenotype [PDF]
PLoS Genetics, 2013 The CDKN1B gene encodes the cyclin-dependent kinase inhibitor p27KIP1, an atypical tumor suppressor playing a key role in cell cycle regulation, cell proliferation, and differentiation.
G. Occhi +15 more
semanticscholar +4 more sources
Translation Initiation from Conserved Non-AUG Codons Provides Additional Layers of Regulation and Coding Capacity [PDF]
mBio, 2017 Neurospora crassa cpc-1 and Saccharomyces cerevisiae GCN4 are homologs specifying transcription activators that drive the transcriptional response to amino acid limitation.
Ivaylo P. Ivanov +11 more
doaj +4 more sources
MicroRNA-34a modulates MDM4 expression via a target site in the open reading frame. [PDF]
PLoS ONE, 2012 BACKGROUND: MDM4, also called MDMX or HDMX in humans, is an important negative regulator of the p53 tumor suppressor. MDM4 is overexpressed in about 17% of all cancers and more frequently in some types, such as colon cancer or retinoblastoma.
Pooja Mandke +5 more
doaj +2 more sources
A positive-sense single-stranded RNA virus acquired a negative-sense open reading frame through recombination. [PDF]
PLoS PathogensAlthough positive- and negative-sense single-stranded RNA viruses are ubiquitous in nature, there is currently no evidence of recombination or reassortment between viruses with these two major forms of genome organization. Here, we describe the discovery
Xuan Dong +15 more
doaj +2 more sources