Results 31 to 40 of about 1,409,999 (372)

Noise reduction by upstream open reading frames

Nature Plants, 2022
AbstractGene expression is prone to burst production, making it a highly noisy process that requires additional controls. Upstream open reading frames (uORFs) are widely present in the 5′ leader sequences of 30–50% of eukaryotic messenger RNAs1–3. The translation of uORFs can repress the translation efficiency of the downstream main coding sequences ...
Ho-Wei Wu, Erickson Fajiculay, Jing-Fen Wu, Ching-Cher Sanders Yan, Chao-Ping Hsu, Shu-Hsing Wu   +5 more
openaire   +2 more sources

SARS-Coronavirus Open Reading Frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes

Cell Death Discovery, 2019
The SARS (severe acute respiratory syndrome) outbreak was caused by a coronavirus (CoV) named the SARS-CoV. SARS pathology is propagated both by direct cytotoxic effects of the virus and aberrant activation of the innate immune response.
C. Shi, Neel R Nabar, N. Huang, J. Kehrl
semanticscholar   +1 more source

Maintenance of the correct open reading frame by the ribosome [PDF]

EMBO reports, 2003
During translation, a string of non‐overlapping triplet codons in messenger RNA is decoded into protein. The ability of a ribosome to decode mRNA without shifting between reading frames is a strict requirement for accurate protein biosynthesis. Despite enormous progress in understanding the mechanism of transfer RNA selection, the mechanism by which ...
Pavel V. Baranov, John F. Atkins, Raymond F. Gesteland, Ivaylo Ivanov, Thomas M Hansen   +4 more
openaire   +3 more sources

Inhibition of Host Gene Expression by KSHV: Sabotaging mRNA Stability and Nuclear Export

Frontiers in Cellular and Infection Microbiology, 2021
Viruses are known for their ability to alter host gene expression. Kaposi sarcoma-associated herpesvirus has two proteins that obstruct host gene expression.
Carissa Ikka Pardamean, Ting-Ting Wu
doaj   +1 more source

Transduplication resulted in the incorporation of two protein-coding sequences into the Turmoil-1 transposable element of C. elegans [PDF]

, 2008
Transposable elements may acquire unrelated gene fragments into their sequences in a process called transduplication. Transduplication of protein-coding genes is common in plants, but is unknown of in animals.
Ast, Gil, Makalowski, Wojciech, Pupko, Tal, Sela, Noa, Stern, Adi   +4 more
core   +4 more sources

Novel exon of mammalian ADAR2 extends open reading frame.

PLoS ONE, 2009
BackgroundThe post-transcriptional processing of pre-mRNAs by RNA editing contributes significantly to the complexity of the mammalian transcriptome. RNA editing by site-selective A-to-I modification also regulates protein function through recoding of ...
Stefan Maas, Willemijn M Gommans
doaj   +1 more source

Short open reading frames (sORFs) and microproteins: an update on their identification and validation measures

Journal of Biomedical Science, 2022
A short open reading frame (sORFs) constitutes ≤ 300 bases, encoding a microprotein or sORF-encoded protein (SEP) which comprises ≤ 100 amino acids. Traditionally dismissed by genome annotation pipelines as meaningless noise, sORFs were found to possess ...
Alyssa Zi-Xin Leong, Pey Yee Lee, M. Aiman Mohtar, Saiful Effendi Syafruddin, Yuh-Fen Pung, Teck Yew Low   +5 more
doaj   +1 more source

SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death

Cell Death and Disease, 2018
The molecular mechanisms underlying the severe lung pathology that occurs during SARS-CoV infections remain incompletely understood. The largest of the SARS-CoV accessory protein open reading frames (SARS 3a) oligomerizes, dynamically inserting into late
Y. Yue, Neel R Nabar, C. Shi, Olena Kamenyeva, Xun Xiao, Il-Young Hwang, Min Wang, J. Kehrl   +7 more
semanticscholar   +1 more source

Improved Identification and Analysis of Small Open Reading Frame Encoded Polypeptides.

Analytical Chemistry, 2016
Computational, genomic, and proteomic approaches have been used to discover nonannotated protein-coding small open reading frames (smORFs). Some novel smORFs have crucial biological roles in cells and organisms, which motivates the search for additional ...
Jiao Ma, J. Diedrich, Irwin Jungreis, C. Donaldson, J. Vaughan, Manolis Kellis, J. Yates, A. Saghatelian   +7 more
semanticscholar   +1 more source

Identification of short open reading frames in plant genomes

Frontiers in Plant Science, 2023
The roles of short/small open reading frames (sORFs) have been increasingly recognized in recent years due to the rapidly growing number of sORFs identified in various organisms due to the development and application of the Ribo-Seq technique, which sequences the ribosome-protected footprints (RPFs) of the translating mRNAs.
Yong Feng, Mengyun Jiang, Mengyun Jiang, Weichang Yu, Weichang Yu, Jiannan Zhou   +5 more
openaire   +3 more sources