Results 31 to 40 of about 1,287,785 (343)

Probing of RNA structures in a positive sense RNA virus reveals selection pressures for structural elements. [PDF]

, 2017
In single stranded (+)-sense RNA viruses, RNA structural elements (SEs) play essential roles in the infection process from replication to encapsidation.
Aviran, Sharon, Choudhary, Krishna, Lucks, Julius B, Perry, Keith L, Thompson, Jeremy R, Watters, Kyle E   +5 more
core   +2 more sources

Short open reading frames (sORFs) and microproteins: an update on their identification and validation measures

Journal of Biomedical Science, 2022
A short open reading frame (sORFs) constitutes ≤ 300 bases, encoding a microprotein or sORF-encoded protein (SEP) which comprises ≤ 100 amino acids. Traditionally dismissed by genome annotation pipelines as meaningless noise, sORFs were found to possess ...
Alyssa Zi-Xin Leong, Pey Yee Lee, M. Aiman Mohtar, Saiful Effendi Syafruddin, Yuh-Fen Pung, Teck Yew Low   +5 more
doaj   +1 more source

Open reading frame cloning: identification, cloning, and expression of open reading frame DNA. [PDF]

Proceedings of the National Academy of Sciences, 1982
A plasmid was constructed that facilitates the cloning and expression of open reading frame DNA. A DNA fragment containing a bacterial promoter and the amino terminus of the cI gene of bacteriophage lambda was fused to an amino-terminally deleted version of the lacZ gene.
M R, Gray, H V, Colot, L, Guarente, M, Rosbash   +3 more
openaire   +2 more sources

PAX6 mutations: genotype-phenotype correlations [PDF]

, 2005
BACKGROUND: The PAX6 protein is a highly conserved transcriptional regulator that is important for normal ocular and neural development. In humans, heterozygous mutations of the PAX6 gene cause aniridia (absence of the iris) and related developmental eye
Hanson, Isabel M, Tzoulaki, Ioanna, White, Ian MS   +2 more
core   +3 more sources

A Novel Mutation in the Upstream Open Reading Frame of the CDKN1B Gene Causes a MEN4 Phenotype [PDF]

, 2013
PubMed ID: 23555276This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Borriello, A Falchetti, A Mehta, A Ozawa, A Wiestner, A Yoon, Alessandro Quattrone, BG Luukkonen, C Le Sage, Carla Scaroni, CC Spevak, CJ Sherr, CJ Sherr, D Malanga, Daniela Regazzo, Denis Ciato, DR Morris, Elena Pardi, Filomena Cetani, Francesca Boaretto, Franco Mantero, G Beffagna, G Johannes, G Occhi, GC Scheper, Giampaolo Trivellin, Gianluca Occhi, Giuseppe Opocher, IM Chu, J Costa-Guda, J Slingerland, K Wethmar, L Liu, L Quintanilla-Martinez, M Georgitsi, M Kozak, M Kozak, M Kullmann, M Matsui, Marshall S. Horwitz, MD Larrea, ML Crowe, ML Fero, Márta Korbonits, Natalia S. Pellegata, NS Pellegata, P Chomczynski, RV Thakker, S Igreja, S Molatore, S Ye, Sara Bobisse, SE Calvo, Sergio Ferasin, SI Reed, SK Agarwal, U Göpfert, Viktoryia Sidarovich, W Zhou, WK Miskimins, Y Wen   +60 more
core   +3 more sources

Characterization of a second open reading frame in genome segment 10 of bluetongue virus [PDF]

, 2015
Viruses have often evolved overlapping reading frames in order to maximise their coding capacity. Until recently, the segmented double-stranded (ds) RNA genome of viruses of the Orbivirus genus was thought to be monocistronic but the identification of ...
Barry, Gerald, Caporale, Marco, Hardy, Alexandra, Hughes, Joseph, Janowicz, Aislynn, Melzi, Eleonora, Palmarini, Massimo, Pinto, Rute Maria, Ratinier, Maxime, Stewart, Meredith, Taggart, Aislynn, Varela, Maria Jose   +11 more
core   +2 more sources

Long Open Reading Frame Transcripts Escape Nonsense-Mediated mRNA Decay in Yeast

Cell Reports, 2014
Nonsense-mediated mRNA decay (NMD) destabilizes eukaryotic transcripts with long 3′ UTRs. To investigate whether other transcript features affect NMD, we generated yeast strains expressing chromosomal-derived mRNAs with 979 different promoter and open ...
Laurence Decourty, Antonia Doyen, Christophe Malabat, Emmanuel Frachon, Delphine Rispal, Bertrand Séraphin, Frank Feuerbach, Alain Jacquier, Cosmin Saveanu   +8 more
doaj   +1 more source

Expression of the murine cytomegalovirus glycoprotein H by recombinant vaccinia virus [PDF]

, 1994
The sequence of the gene encoding glycoprotein H (gH) of murine cytomegalovirus (MCMV) strain Smith was determined and compared with the sequence of the gH of MCMV strain K181. Transcriptional analysis showed that gH is encoded by a large mRNA of 5.0 kb,
Koszinowski, Ulrich H., Loh, Lambert C., Lucin, Pero, Messerle, Martin, Rapp, Maria   +4 more
core   +1 more source

Identification and characterization of a novel non-structural protein of bluetongue virus [PDF]

, 2011
Bluetongue virus (BTV) is the causative agent of a major disease of livestock (bluetongue). For over two decades, it has been widely accepted that the 10 segments of the dsRNA genome of BTV encode for 7 structural and 3 non-structural proteins.
AA Van Dijk, AE Firth, AE Firth, AG Aminev, AG Aminev, AJ Wilson, Alessia Armezzani, Amr Bayoumy, Andrew Shaw, B Sherry, BJ Erasmus, C Gonzalez-Lopez, C Lee, C Vinson, CC Celma, CD DeMaula, CR Rinaldo Jr, D Grimm, E Calvo-Pinilla, E Calvo-Pinilla, E Matsuo, EL Nason, EW Rainsford, F Arnaud, FM Boisvert, Frazer Rixon, FW Bazer, G Sutton, G Van Heeke, Giulia Franzoni, I Schwartz-Cornil, JA Hiscox, JA Hiscox, JA Mertz, JM Grimes, JM Wehrfritz, Kathryn Allan, L Vazquez-Iglesias, LJ Reed, M Barro, M Boyce, M Boyce, M Caporale, M Caporale, M Marfori, M Mura, M Neville, M Palmarini, M Rojas, M Varela, MA Hofmann, Marco Caporale, Mark Heise, Massimo Palmarini, Matthew Golder, Maxime Ratinier, ME Peeples, MH Malim, MK Estes, MM Arnold, MR Michel, MR Yang, MS Lindstrom, N Feng, N Stauber, NJ Horscroft, NJ Maclachlan, NJ Maclachlan, NJ MacLachlan, NM Foster, P Franchi, P Gouet, P Jameson, P Roy, P Roy, PP Mertens, PP Mertens, PS Mellor, R Dulbecco, R Noad, R Volmer, RE Randall, RJ Owens, S Boulon, S Brandt, S Maan, S Maan, Sandro Filipe Nunes, SH Wang, SJ Wechsler, X Zhang, Z Han   +91 more
core   +4 more sources

ORFeus: a computational method to detect programmed ribosomal frameshifts and other non-canonical translation events

BMC Bioinformatics, 2023
Background In canonical protein translation, ribosomes initiate translation at a specific start codon, maintain a single reading frame throughout elongation, and terminate at the first in-frame stop codon.
Mary O. Richardson, Sean R. Eddy
doaj   +1 more source