Results 41 to 50 of about 1,440,104 (391)

The Hepatitis E Virus Open Reading Frame 2 Protein: Beyond Viral Capsid

Frontiers in Microbiology, 2021
Hepatitis E virus (HEV) is a zoonotic pathogen causing hepatitis in both human and animal hosts, which is responsible for acute hepatitis E outbreaks worldwide. The 7.2 kb genome of the HEV encodes three well-defined open reading frames (ORFs), where the
Zhaobin Zhou, Zhaobin Zhou, Yinqian Xie, Chunyan Wu, Chunyan Wu, Yuchen Nan, Yuchen Nan   +6 more
doaj   +1 more source

Evolutionary divergence of novel open reading frames in cichlids speciation [PDF]

Scientific Reports, 2020
AbstractNovel open reading frames (nORFs) with coding potential may arise from noncoding DNA. Not much is known about their emergence, functional role, fixation in a population or contribution to adaptive radiation. Cichlids fishes exhibit extensive phenotypic diversification and speciation.
Yagnesh Urmania, Eric A. Miska, Eric A. Miska, Jaime San Miguel Navas, Thomas Willis, Matthew T. Wayland, Grégoire Vernaz, Grégoire Vernaz, Ruchi Chauhan, Shraddha Puntambekar, Sudhakaran Prabakaran, Sudhakaran Prabakaran, Rachel Newhouse   +12 more
openaire   +8 more sources

Identification of a protein encoded in the EB-viral open reading frame BMRF2 [PDF]

, 1992
Using monospecific rabbit sera against a peptide derived from a potential antigenic region of the Epstein-Barr viral amino acid sequence encoded in the open reading frame BMRF2 we could identify a protein-complex of 53/55 kDa in chemically induced B95-8,
A. v. Brunn, B Böttinger, E Tschachler, G Myers, GJ Clements, GJ LaRosa, H Takahashi, H Takahashi, H Takahashi, H. Fließbach, H. Wolf, HK Lyerly, HK Lyerly, J Goudsmit, J Goudsmit, JE Gregersen, K Javaherian, K Javaherian, LA Lasky, M Clerici, M Clerici, M. Niedrig, NL Haigwood, P Simmonds, PJ Durda, PW Berman, R Wagner, R. Wagner, RA Neurath, RH Meloen, S Modrow, S Modrow, SD Putney, Susanne Modrow, T Hattori, TJ Palker, Traudel Böltz, Y Devash   +37 more
core   +2 more sources

Probing of RNA structures in a positive sense RNA virus reveals selection pressures for structural elements. [PDF]

, 2017
In single stranded (+)-sense RNA viruses, RNA structural elements (SEs) play essential roles in the infection process from replication to encapsidation.
Aviran, Sharon, Choudhary, Krishna, Lucks, Julius B, Perry, Keith L, Thompson, Jeremy R, Watters, Kyle E   +5 more
core   +2 more sources

Short open reading frames (sORFs) and microproteins: an update on their identification and validation measures

Journal of Biomedical Science, 2022
A short open reading frame (sORFs) constitutes ≤ 300 bases, encoding a microprotein or sORF-encoded protein (SEP) which comprises ≤ 100 amino acids. Traditionally dismissed by genome annotation pipelines as meaningless noise, sORFs were found to possess ...
Alyssa Zi-Xin Leong, Pey Yee Lee, M. Aiman Mohtar, Saiful Effendi Syafruddin, Yuh-Fen Pung, Teck Yew Low   +5 more
doaj   +1 more source

Conserved upstream open reading frames in higher plants [PDF]

BMC Genomics, 2008
Abstract Background Upstream open reading frames (uORFs) can down-regulate the translation of the main open reading frame (mORF) through two broad mechanisms: ribosomal stalling and reducing reinitiation efficiency. In distantly related plants, such as rice and Arabidopsis, it has been found that conserved uORFs are ...
Tran, M., Schultz, C., Baumann, U.
openaire   +5 more sources

PAX6 mutations: genotype-phenotype correlations [PDF]

, 2005
BACKGROUND: The PAX6 protein is a highly conserved transcriptional regulator that is important for normal ocular and neural development. In humans, heterozygous mutations of the PAX6 gene cause aniridia (absence of the iris) and related developmental eye
Hanson, Isabel M, Tzoulaki, Ioanna, White, Ian MS   +2 more
core   +3 more sources

OrfM: a fast open reading frame predictor for metagenomic data

Bioinform., 2016
Summary: Finding and translating stretches of DNA lacking stop codons is a task common in the analysis of sequence data. However, the computational tools for finding open reading frames are sufficiently slow that they are becoming a bottleneck as the ...
B. Woodcroft, J. Boyd, G. Tyson
semanticscholar   +1 more source

Evidence for Translational Repression of the SOCS-1 Major Open Reading Frame by an Upstream Open Reading Frame

Biochemical and Biophysical Research Communications, 2000
The suppressor of cytokine signalling 1 protein (SOCS-1) belongs to a novel family of cytokine inducible factors which function as inhibitors of the JAK/STAT pathway. While SOCS-1 previously has been described as a single-exon gene, here we present evidence for an additional 5' exon, separated by a 509 bp intron from exon 2.
Schluter, G., Boinska, D., Nieman-Seyde, S. C.   +2 more
openaire   +4 more sources

Long Open Reading Frame Transcripts Escape Nonsense-Mediated mRNA Decay in Yeast

Cell Reports, 2014
Nonsense-mediated mRNA decay (NMD) destabilizes eukaryotic transcripts with long 3′ UTRs. To investigate whether other transcript features affect NMD, we generated yeast strains expressing chromosomal-derived mRNAs with 979 different promoter and open ...
Laurence Decourty, Antonia Doyen, Christophe Malabat, Emmanuel Frachon, Delphine Rispal, Bertrand Séraphin, Frank Feuerbach, Alain Jacquier, Cosmin Saveanu   +8 more
doaj   +1 more source