Results 41 to 50 of about 1,287,785 (343)
Peptidomic discovery of short open reading frame-encoded peptides in human cells [PDF]
, 2014 The amount of the transcriptome that is translated into polypeptides is of fundamental importance. We developed a peptidomic strategy to detect short ORF (sORF)-encoded polypeptides (SEPs) in human cells. We identified 90 SEPs, 86 of which are novel, the
Budnik, Bogdan A. +9 more
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Noise reduction by upstream open reading frames
Nature Plants, 2022 AbstractGene expression is prone to burst production, making it a highly noisy process that requires additional controls. Upstream open reading frames (uORFs) are widely present in the 5′ leader sequences of 30–50% of eukaryotic messenger RNAs1–3. The translation of uORFs can repress the translation efficiency of the downstream main coding sequences ...
Ho-Wei Wu +5 more
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Temperature-dependent regulation of upstream open reading frame translation in S. cerevisiae
BMC Biology, 2019 Background Translation of an mRNA in eukaryotes starts at an AUG codon in most cases, but near-cognate codons (NCCs) such as UUG, ACG, and AUU can also be used as start sites at low levels in Saccharomyces cerevisiae.
Shardul D. Kulkarni +5 more
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A Proteomic Approach to Study the Biological Role of Hepatitis C Virus Protein Core+1/ARFP
Viruses, 2022 Hepatitis C virus is the major cause of chronic liver diseases and the only cytoplasmic RNA virus known to be oncogenic in humans. The viral genome gives rise to ten mature proteins and to additional proteins, which are the products of alternative ...
Vasileios Vrazas +6 more
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Molecular Plant-Microbe Interactions, 1999 The cell wall acts as the first line of defense during pathogen invasion. Polygalacturonases (PGs) are a class of cell-wall-modifying enzymes with precise temporal and organ-specific expression.
Ramamurthy Mahalingam +2 more
doaj +1 more source
BioTechniques, 2007 We have developed a novel vector, pTCS, as a tool for efficient selection of open reading frame (ORF)-containing inserts. In pTCS clones containing an insert with an ORF, a downstream marker gene (immE3, conferring resistance to colicin) is activated via
Sumiko Ohashi-Kunihiro +3 more
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Replication enhancer elements within the open reading frame of tick-borne encephalitis virus and their evolution within the Flavivirus genus [PDF]
, 2011 We provide experimental evidence of a replication enhancer element (REE) within the capsid gene of tick-borne encephalitis virus (TBEV, genus Flavivirus).
Buckley, A. +5 more
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Characterization of Hemagglutinin Negative Botulinum Progenitor Toxins
Toxins, 2017 Botulism is a disease involving intoxication with botulinum neurotoxins (BoNTs), toxic proteins produced by Clostridium botulinum and other clostridia. The 150 kDa neurotoxin is produced in conjunction with other proteins to form the botulinum progenitor
Suzanne R. Kalb +4 more
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Emerging role of long noncoding RNA-encoded micropeptides in cancer
Cancer Cell International, 2020 Increasing evidence has indicated that long noncoding RNAs (lncRNAs) play various important roles in the development of cancers. The widespread applications of ribosome profiling and ribosome nascent chain complex sequencing revealed that some short open
Mujie Ye +4 more
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An open reading frame upstream from the nifH gene of Klebsiella pneumoniae [PDF]
, 1983 An open reading frame upstream from nifHDK operon of Klebsiella pneumoniae had been described. The orientation of this open reading frame is opposite to that of nifHDK and sequence homology was found between the open reading frame promoter and the ...
Kong, Qiu-tong +3 more
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