Results 51 to 60 of about 1,287,785 (343)

Flatworms have lost the right open reading frame kinase 3 gene during evolution [PDF]

, 2015
All multicellular organisms studied to date have three right open reading frame kinase genes (designated riok-1, riok-2 and riok-3). Current evidence indicates that riok-1 and riok-2 have essential roles in ribosome biosynthesis, and that the riok-3 gene
Amani, Parisa, Ansell, Brendan R. E., Boag, Peter R., Breugelmans, Bert, Gasser, Robin B., Hofmann, Andreas, Jex, Aaron R., Sternberg, Paul W., Stroehlein, Andreas J., Young, Neil D.   +9 more
core   +1 more source

Pneumococcal Gene Complex Involved in Resistance to Extracellular Oxidative Stress [PDF]

, 2012
Streptococcus pneumoniae is a Gram-positive bacterium which is a member of the normal human nasopharyngeal flora but can also cause serious disease such as pneumonia, bacteremia, and meningitis. Throughout its life cycle, S.
Anne de Jong, Barbuti, Battig, Bijlsma, Bogaert, Bortoni, Braun, Brot, Bus, Carlos J. Orihuela, Cecilia A. Hinojosa, Chae, Chen, de Ruyter, Dopazo, Duane, Even, Falord, Haasum, Hendriksen, Hiller, Hirst, Holmgren, Holmgren, Hoshi, Hoskins, Ibrahim, Imlay, Imlay, J. N. Weiser, Jetta J. E. Bijlsma, Kadioglu, Kim, Kloosterman, Kloosterman, Kuipers, Lau, Liu, Liu, Liu, Marchler-Bauer, Margolis, Martner, Matthias, McAllister, Miller, Neef, Novak, Obert, Orihuela, Oscar P. Kuipers, Park, Parra-Lopez, Paterson, Pearce, Pericone, Pericone, Pericone, Pesakhov, Petit, Potter, Ramos-Montanez, Regev-Yochay, Robertson, Rosen, Schaper, Skaar, Spellerberg, Sun, Terzaghi, Tettelin, Tseng, Vahid Farshchi Andisi, Yesilkaya, Ziegelhoffer, Zweers   +75 more
core   +8 more sources

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

A Coding Sequence-Embedded Principle Governs Translational Reading Frame Fidelity

Research, 2018
Upon initiation at a start codon, the ribosome must maintain the correct reading frame for hundreds of codons in order to produce functional proteins. While some sequence elements are able to trigger programmed ribosomal frameshifting (PRF), very little ...
Ji Wan, Xiangwei Gao, Yuanhui Mao, Xingqian Zhang, Shu-Bing Qian   +4 more
doaj   +1 more source

TRAPID : an efficient online tool for the functional and comparative analysis of de novo RNA-Seq transcriptomes [PDF]

, 2013
Transcriptome analysis through next-generation sequencing technologies allows the generation of detailed gene catalogs for non-model species, at the cost of new challenges with regards to computational requirements and bioinformatics expertise.
Deforce, Dieter, Proost, Sebastian, Van Bel, Michiel, Van de Peer, Yves, Van Neste, Christophe, Vandepoele, Klaas   +5 more
core   +2 more sources

AlterORF: a database of alternate open reading frames [PDF]

Nucleic Acids Research, 2007
AlterORF is a searchable database that contains information regarding alternate open reading frames (ORFs) for over 1.5 million genes in 481 prokaryotic genomes. The objective of the database is to provide a platform for improving genome annotation and to serve as an aid for the identification of prokaryotic genes that potentially encode proteins in ...
Pedroso, Inti, Rivera, Gustavo, Lazo, Felipe, Chacon, Max, Ossandon, Francisco, Veloso, Felipe A., Holmes, David S.   +6 more
openaire   +9 more sources

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Quantitative sequence and open reading frame analysis based on codon bias [PDF]

Journal of Systemics, Cybernetics and Informatics, 2006
The frequencies with which the sixty-four codons occur in human coding DNA are known. If we assume that the codons occur randomly, subject only to these probabilities, then it is possible to predict trinucleotide frequencies in each of the five other ...
Susan Rainey, Joe Repka
doaj  

Conserved upstream open reading frames in higher plants [PDF]

BMC Genomics, 2008
Abstract Background Upstream open reading frames (uORFs) can down-regulate the translation of the main open reading frame (mORF) through two broad mechanisms: ribosomal stalling and reducing reinitiation efficiency. In distantly related plants, such as rice and Arabidopsis, it has been found that conserved uORFs are ...
Tran, M., Schultz, C., Baumann, U.
openaire   +4 more sources

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source