Results 41 to 50 of about 627,878 (334)

Conserved elements within open reading frames of mammalian Hox genes

open access: yesJournal of Biology, 2009
A recent study in BMC Evolutionary Biology shows that many of the open reading frames in mammalian Hox genes are more conserved than expected on the basis of their protein sequence.
Woltering Joost M, Duboule Denis
doaj   +1 more source

Genome sequence of jumbo phage vB_AbaM_ME3 of Acinetobacter baumanni [PDF]

open access: yes, 2016
Bacteriophage (phage) vB_AbaM_ME3 was previously isolated from wastewater effluent using the propagating host Acinetobacter baumannii DSM 30007. The full genome was sequenced, revealing it to be the largest Acinetobacter bacteriophage sequenced to date ...
Buttimer, Colin   +8 more
core   +2 more sources

uORF-Tools-Workflow for the determination of translation-regulatory upstream open reading frames.

open access: yesPLoS ONE, 2019
Ribosome profiling (ribo-seq) provides a means to analyze active translation by determining ribosome occupancy in a transcriptome-wide manner. The vast majority of ribosome protected fragments (RPFs) resides within the protein-coding sequence of mRNAs ...
Anica Scholz   +7 more
doaj   +1 more source

Evidence of a Set of Core-Function Genes in 16 Bacillus Podoviral Genomes with Considerable Genomic Diversity

open access: yesViruses, 2023
Bacteriophage genomes represent an enormous level of genetic diversity and provide considerable potential to acquire new insights about viral genome evolution. In this study, the genome sequences of sixteen Bacillus-infecting bacteriophages were explored
Ahmed Ismail   +6 more
doaj   +1 more source

Mini-Exon Epitope Tagging for Analysis of the Protein Coding Potential of Genomic Sequence

open access: yesBioTechniques, 1997
A novel approach to gene discovery and analysis is described. A small exon flanked by consensus 3′ and 5′ splice sites was synthesized. The exon contains open reading frames encoding 43 amino acid peptides.
Desmond J. Smith
doaj   +1 more source

Complete genome sequence of a Pseudomonas putida clinical isolate, strain H8234 [PDF]

open access: yes, 2013
We report the complete genome sequence of Pseudomonas putida strain H8234, which was isolated from a hospital patient presenting with bacteremia. This strain has a single chromosome (6,870,827 bp) that contains 6,305 open reading frames.
Bernal, P   +4 more
core   +2 more sources

ORFer – retrieval of protein sequences and open reading frames from GenBank and storage into relational databases or text files

open access: yesBMC Bioinformatics, 2002
Background Functional genomics involves the parallel experimentation with large sets of proteins. This requires management of large sets of open reading frames as a prerequisite of the cloning and recombinant expression of these proteins.
Sievert Volker   +2 more
doaj   +1 more source

Disrupting upstream translation in mRNAs is associated with human disease

open access: yesNature Communications, 2021
The significance of translated upstream open reading frames is not well known. Here, the authors investigate genetic variants in these regions, finding that they are under high evolutionary constraint and may contribute to disease.
David S. M. Lee   +7 more
doaj   +1 more source

Page turning system [PDF]

open access: yes, 1992
A device for holding reading materials for use by readers without arm mobility is presented. The device is adapted to hold the reading materials in position for reading with the pages displayed to enable turning by use of a rubber tipped stick that is ...
Eklund, Wayne D., Kerley, James J.
core   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

open access: yesFEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue   +6 more
wiley   +1 more source

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