Human SARS-CoV-2 has evolved to reduce CG dinucleotide in its open reading frames
Scientific Reports, 2020 The outbreak of COVID-19 has brought great threat to human health. Its causative agent is a severe acute respiratory syndrome-related coronavirus which has been officially named SARS-CoV-2.
Yong Wang +6 more
semanticscholar +1 more source
Predicting functional upstream open reading frames in
BMC Bioinformatics, 2009 Background Some upstream open reading frames (uORFs) regulate gene expression (i.e., they are functional) and can play key roles in keeping organisms healthy. However, how uORFs are involved in gene regulation is not yet fully understood. In order to get
Kristiansson Erik +5 more
doaj +1 more source
Evolutionary divergence of novel open reading frames in cichlids speciation
Scientific Reports, 2020 Novel open reading frames (nORFs) with coding potential may arise from noncoding DNA. Not much is known about their emergence, functional role, fixation in a population or contribution to adaptive radiation.
Shraddha Puntambekar +9 more
doaj +1 more source
REPARATION : ribosome profiling assisted (re-)annotation of bacterial genomes [PDF]
, 2017 Prokaryotic genome annotation is highly dependent on automated methods, as manual curation cannot keep up with the exponential growth of sequenced genomes.
Giess, Adam +5 more
core +1 more source
Predicting statistical properties of open reading frames in bacterial genomes.
PLoS ONE, 2012 An analytical model based on the statistical properties of Open Reading Frames (ORFs) of eubacterial genomes such as codon composition and sequence length of all reading frames was developed.
Katharina Mir +4 more
doaj +1 more source
Open reading frame cloning: identification, cloning, and expression of open reading frame DNA. [PDF]
Proceedings of the National Academy of Sciences, 1982 A plasmid was constructed that facilitates the cloning and expression of open reading frame DNA. A DNA fragment containing a bacterial promoter and the amino terminus of the cI gene of bacteriophage lambda was fused to an amino-terminally deleted version of the lacZ gene.
M R, Gray +3 more
openaire +2 more sources
Genome-wide gene expression analysis of anguillid herpesvirus 1 [PDF]
, 2013 <p>Background: Whereas temporal gene expression in mammalian herpesviruses has been studied extensively, little is known about gene expression in fish herpesviruses.
Davison, A.J. +4 more
core +3 more sources
Accurate annotation of human protein-coding small open reading frames
Nature Chemical Biology, 2019 Functional protein-coding small open reading frames (smORFs) are emerging as an important class of genes. However, the number of translated smORFs in the human genome is unclear because proteogenomic methods are not sensitive enough, and, as we show ...
Thomas F. Martinez +5 more
semanticscholar +1 more source
Small Open Reading Frames, Non-Coding RNAs and Repetitive Elements in Bradyrhizobium japonicum USDA 110 [PDF]
, 2016 Small open reading frames (sORFs) and genes for non-coding RNAs are poorly investigated components of most genomes. Our analysis of 1391 ORFs recently annotated in the soybean symbiont Bradyrhizobium japonicum USDA 110 revealed that 78% of them contain ...
Cuklina, Jelena +5 more
core +2 more sources
Automated Prediction and Annotation of Small Open Reading Frames in Microbial Genomes.
Cell Host and Microbe, 2020 Small open reading frames (smORFs) and their encoded microproteins play central roles in microbes. However, there is a vast unexplored space of smORFs within human-associated microbes.
M. Durrant, A. Bhatt
semanticscholar +1 more source