Results 91 to 100 of about 277,157 (310)
Dynamic behavior of stochastic gene expression models in the presence of bursting
, 2013 This paper considers the behavior of discrete and continuous mathematical models for gene expression in the presence of transcriptional/translational bursting. We treat this problem in generality with respect to the distribution of the burst size as well
Mackey, M. C. +2 more
core +2 more sources
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
An innovative analytical method utilizing aboodh residual power series for solving the time-fractional newell-whitehead-segel equation [PDF]
Computational Algorithms and Numerical DimensionsIn this study, we use a new method called Abode Residual Power Series Method (ARPSM) to derive the analytical results of the Newell-Whitehead-Siegel equation.
Seyed Edalatpanah, Eisa Abdolmaleki
doaj +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Identification of the parameters of the stochastic Preisach operator
Mathematics in EngineeringIn this paper, we propose a method for identifying the measure of the stochastic Preisach operator using machine learning techniques. The classical Preisach operator model is widely used to describe hysteresis phenomena in various fields such as physics,
Aleksandr I. Proshunin +2 more
doaj +1 more source
Computational biology approach to uncover hepatitis C virus helicase operation
World Journal of Gastroenterology, 2014 22 pages, 5 ...
openaire +4 more sources
Molecular Oncology, EarlyView.Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser +14 more
wiley +1 more source
Scientific ReportsDetecting protein complexes is crucial in computational biology for understanding cellular mechanisms and facilitating drug discovery. Evolutionary algorithms (EAs) have proven effective in uncovering protein complexes within networks of protein–protein ...
Mustafa N. Abbas +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source