Results 121 to 130 of about 648,698 (363)

CASTNet: Community-Attentive Spatio-Temporal Networks for Opioid Overdose Forecasting

, 2019
Opioid overdose is a growing public health crisis in the United States. This crisis, recognized as "opioid epidemic," has widespread societal consequences including the degradation of health, and the increase in crime rates and family problems.
A Kennedy-Hendricks, A Kolodny, AM Ertugrul, DS Burke, H Jalal, M Pierce, M Warner, NB King, PJ Gruenewald, R Hammersley, RA Rudd, S Hochreiter, S Scardapane, T Bennett, T Seddon   +14 more
core   +1 more source

Pregabalin dependence, withdrawal, suicidality and psychosis reports: A disproportionality analysis of the Australian adverse events database

British Journal of Clinical Pharmacology, EarlyView.
Aims Globally, Australia has the highest per capita consumption rate of pregabalin, commonly prescribed for neuropathic pain. Emerging evidence suggests pregabalin may be associated with the onset or recurrence of several potentially life‐threatening psychiatric events in some individuals.
Amy G. McNeilage, Ali Gholamrezaei, Bridin Murnion, Suzanne Nielsen, Claire E. Ashton‐James   +4 more
wiley   +1 more source

Medical encounters for opioid-related intoxications in Southern Nevada: sociodemographic and clinical correlates

BMC Health Services Research, 2016
BackgroundDespite today’s heightened concern over opioid overdose, the lack of population-based data examining clinical and contextual factors associated with opioid use represents a knowledge gap with relevance to prevention and treatment interventions.
Jing Feng, J. Iser, Wei Yang
semanticscholar   +1 more source

Confronting the opioid crisis: Practical pain management and strategies: AOA 2018 critical issues symposium [PDF]

, 2019
The United States is in the midst of an opioid crisis. Clinicians have been part of the problem because of overprescribing of narcotics for perioperative pain management.
Hsu, Joseph R, Jahangir, A Alex, Miller, Anna N, Mir, Hassan R, Obremskey, William T   +4 more
core   +1 more source

BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates [PDF]

, 2019
© 2019 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.Background: The marked increase in mis-use of prescription opioids has greatly affected our society. One potential solution is to develop improved analgesics which have
Cami-Kobeci, Gerta, Czoty, Paul W., DeLoid, Heather B., Ding, Huiping, Hsu, Fang Chi, Husbands, Stephen M., Kiguchi, Norikazu, Ko, Mei Chuan, Sukhtankar, Devki D., Toll, Lawrence   +9 more
core   +4 more sources

Prescription use of acetaminophen among pregnant women in Denmark from 2000 to 2023: A drug utilization study

British Journal of Clinical Pharmacology, EarlyView.
Aims The aim of this study was to describe prescription use of acetaminophen, a widely used analgesic and antipyretic generally considered safe during pregnancy, among pregnant women from 2000 to 2023 in Denmark with special attention towards variations following the change in over‐the‐counter (OTC) availability in 2013.
Erika B. Gram, Mette Bliddal, Sophie Pflugfelder, Peter Bjødstrup Jensen, Per Damkier   +4 more
wiley   +1 more source

Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application

BMEMat, EarlyView.
The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah, Xingxing Li, Hao Yuan, Huiling Shen, Shaohao Quan, Guifang Pan, Muhammad Ishfaq, Abid Ullah Shah, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source

Is There Less Opioid Abuse in States Where Marijuana Has Been Decriminalized, Either for Medicinal or Recreational Use? A Clin-IQ

Journal of Patient-Centered Research and Reviews, 2019
Opioid use, abuse, and associated mortality have reached an epidemic level. In some states, cannabis is being used to treat chronic pain. To examine the hypothesis that medical marijuana legislation may reduce adverse opioid-related outcomes if patients ...
Aaron M. Wendelboe, Richard Mathew, Tana Chongsuwat, Elizabeth Rainwater, Mark A. Wendelboe, Elizabeth Wickersham, Ann F. Chou   +6 more
doaj   +1 more source

Heroin-piracetam mixture: suggested mechanisms of action and risks of misinterpretation for drug users [PDF]

, 2017
Piracetam is a positive allosteric modulator of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor that has been frequently used in the treatment of cognitive disorders.
Cappelletti, Simone, Ciallella, Costantino, Lombardo, Francesco, Vallone, Giuseppe, Vitale, Pasquale   +4 more
core   +1 more source

Carum carvi and Ormenis multicaulis Extracts: Chemical Analysis and In Vivo Experiments to Evaluate the Synergistic Analgesic and Anti‐Inflammatory Effects

Chemistry &Biodiversity, EarlyView.
ABSTRACT The purpose of the present investigation was to determine the effects of combination of Ormenis multicaulis dry flower methanolic extracts and Carum carvi seed methanolic extracts on pain and inflammation, compared to their use separately. High‐performance liquid chromatography (HPLC) analysis of methanolic extracts showed the presence of ...
El Mahdi Wakrim, Karima Raoui, Hamid Kabdy, Jawad Laadraoui, Mehdi Ait Laaradia, Chafik Terrafe, Sami Mnif, Brahim Bouizgarne, Stefania Garzoli, Abderrahman Chait   +9 more
wiley   +1 more source