Results 211 to 220 of about 205,220 (260)

Alkalinised lidocaine as an anaesthetic before onabotulinumtoxinA injections. a randomised trial

BJU International, Volume 135, Issue 4, Page 638-647, April 2025.
Objectives To evaluate the effect of intravesical alkalinised lidocaine as an anaesthetic treatment on procedural pain during intradetrusor onabotulinumtoxinA (BTX‐A) injections for overactive bladder. Patients and Methods This single‐centre, randomised, double‐blind, placebo‐controlled two period crossover trial was conducted on women scheduled for ...
Meryam El Issaoui, Marlene Elmelund, Niels Klarskov   +2 more
wiley   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

Psilocybin as a novel treatment for chronic pain

British Journal of Pharmacology, EarlyView.
Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey, Reena Lasrado, Maria Maiarú, Gary J. Stephens   +3 more
wiley   +1 more source

Evidence that 5‐HT2A receptor signalling efficacy and not biased agonism differentiates serotonergic psychedelic from non‐psychedelic drugs

British Journal of Pharmacology, EarlyView.
Background and Purpose Serotonergic psychedelic drugs are under investigation as therapies for various psychiatric disorders, including major depression. Although serotonergic psychedelic drugs are 5‐HT2A receptor agonists, some such agonists are not psychedelic, potentially due to differences in 5‐HT2A receptor ligand bias or signalling efficacy. Here,
Aurelija Ippolito, Sridhar Vasudevan, Shaun Hurley, Gary Gilmour, Frederick Westhorpe, Grant Churchill, Trevor Sharp   +6 more
wiley   +1 more source

Activation of peripheral NOP receptors reduces periorbital mechanical allodynia evoked by CGRP in mice

British Journal of Pharmacology, EarlyView.
Background and Purpose Migraine is a neurovascular disorder largely mediated by calcitonin gene‐related peptide (CGRP). This study explores the role of the nociceptin/orphanin FQ (N/OFQ)–N/OFQ receptor (NOP) system in CGRP‐induced periorbital mechanical allodynia (PMA) in mice.
Chiara Sturaro, Pietro Pola, Michela Argentieri, Alessia Frezza, Matilde Marini, Francesco De Logu, Valentina Albanese, Marie Soukupova, Davide Malfacini, Nurulain T. Zaveri, Romina Nassini, Dane D. Jensen, Pierangelo Geppetti, Girolamo Calò, Chiara Ruzza   +14 more
wiley   +1 more source

Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology

British Journal of Pharmacology, EarlyView.
Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller, Gary Gudelsky, T. John Winhusen, Davide Amato   +3 more
wiley   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Opioid-Related Sleep-Disordered Breathing: An Update for Clinicians

American Journal of Hospice and Palliative Medicine®, 2020
Opioids are an effective treatment for patients with intractable pain. Long-term administration of opioids for pain relief is being delivered by an increasing number of medical providers in the United States including primary care physicians and nonspecialists. One common complication of chronic opioid use is sleep-disordered breathing which can result
Waqas Jehangir, Alexander D. Karabachev, Zankhana Mehta, Mellar Davis   +3 more
openaire   +2 more sources

Perception of Pharmacy Students Toward Opioid-Related Disorders and Roles of Community Pharmacists: A French Nationwide Cross-Sectional Study

Substance Abuse, 2021
Background Community pharmacists are among the frontline health professionals who manage patients with an opioid-related disorder (ORD). Pharmacists frequently have a negative attitude toward these patients, which could have a negative impact on their management.
Balayssac, David, Pereira, Bruno, Cuq, Pierre, Douris, Juliette, Ferrari, Luc, Boutet-Robinet, Elisa, Lechevrel, Mathilde, Demeilliers, Christine, Rat, Patrice, Coudoré, François, Verron, Elise, Lacarelle, Bruno, Guitton, Jérôme, Courtois, Arnaud, Allorge, Delphine, Pain, Stéphanie, Guerbet, Michel, Collin, Aurore, Vennat, Brigitte, Brousse, Georges, Authier, Nicolas, Laporte, Catherine   +21 more
openaire   +5 more sources

Prior Diagnosis of Opioid‐Related Disorder Is Associated With Higher Medical Resource Utilization Following Primary Hip Arthroscopy: A National Database Study

Arthroscopy, 2023
Purpose To compare adverse events, medical resource utilization, prescribing patterns, and revision surgery rates of patients with opioid‐related disorders (ORDs) undergoing primary hip arthroscopy against a propensity‐matched group with no opioid‐related disorders (NORDs).
Peter F, Monahan, Serkan, Surucu, Natalie K, Pahapill, Andrew E, Jimenez, Kenneth F, Taylor   +4 more
openaire   +2 more sources

Patterns of Buprenorphine Initiation Treatment for Opioid Use Disorder and Association with Opioid-related Overdose Deaths

2022
Oral presentation at the 38th International Society for ...
Hammerslag, Lindsey, Slavova, Svetla, Freeman, Patricia R, DiPrete, Bethany , Slade, Emily, Lofwall, Michelle, Lei, Feitong, Dasgupta, Nabarun, Moga, Daniela   +8 more
openaire   +1 more source