Results 51 to 60 of about 10,078,256 (288)

Acute opioid overdose in pediatric patients

Journal of the American College of Emergency Physicians Open
Recent increases in pediatric and adolescent opioid fatalities mandate an urgent need for early consideration of possible opioid exposure and specific diagnostic and management strategies and interventions tailored to these unique populations.
Stephen Sandelich, Gwen Hooley, George Hsu, Emily Rose, Tim Ruttan, Evan S. Schwarz, Erin Simon, Carmen Sulton, Jessica Wall, Ann M Dietrich   +9 more
doaj   +1 more source

Leveraging the role of community pharmacists in the prevention, surveillance, and treatment of opioid use disorders

Addiction Science & Clinical Practice, 2019
The global rise in opioid-related harms has impacted the United States severely. Current efforts to manage the opioid crisis have prompted a re-evaluation of many of the existing roles in the healthcare system, in order to maximize their individual ...
Paxton Bach, Daniel Hartung
doaj   +1 more source

Kappa Opioid Regulation of Stress-Related Behavior [PDF]

, 2010
Anxiety disorders affect roughly 40 million American adults in a given year. Those suffering from anxiety disorders often experience additional stress-linked illnesses, such as depression.
Harshberger, Erin
core  

Safety of opioid patch initiation in Australian residential aged care [PDF]

, 2015
Explores opioid use by aged care facility residents before and after initiation of transdermal opioid patches. Abstract Objective: To explore opioid use by aged care facility residents before and after initiation of transdermal opioid patches. Design:
Lisa Pont, Svetla Gadzhanova, Elizabeth Roughead, Roughead, E.E., Pont, L.G., Gadzhanova, S.   +5 more
core   +1 more source

Effectiveness of Resistance Intradialytic Exercise Compared to Aerobic Intradialytic Exercise for Patients With Chronic Kidney Disease: A Randomized Controlled Clinical Trial

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida, Gisela Cristiane Miyamoto, Daniel da Costa Torres, Ian Setubal Reis Chaves, Jonas do Carmo Paschoalin, Braúlio Lima Nascimento, Luciana Dias Chiavegato   +6 more
wiley   +1 more source

Boundary‐Dependent Sleep–Wake Dysregulation in Idiopathic Hypersomnia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Idiopathic hypersomnia (IH) presents with excessive daytime sleepiness (EDS) despite apparently preserved nocturnal sleep, challenging traditional models of hypersomnolence based on sleep loss or fragmentation. We aimed to test the hypothesis that EDS in IH reflects excessive stabilization of the sleep state, consistent with ...
Samantha Mombelli, Karine Lacourse, Hélène Blais, Anne‐Sophie Deshaies‐Rugama, Cynthia Thompson, Alex Desautels, Jacques Montplaisir, Milan Nigam, Christophe Moderie, Boshra Khajehpiri, Catherine Duclos, Jean Marc Lina, Julie Carrier, Nadia Gosselin   +13 more
wiley   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Stress-evoked opioid release inhibits pain in major depressive disorder [PDF]

, 2008
To determine whether stress-evoked release of endogenous opioids might account for hypoalgesia in major depressive disorder (MDD), the μ-opioid antagonist naltrexone (50 mg) or placebo was administered double-blind to 24 participants with MDD and to 31 ...
Frew, A.K., Drummond, P.D.
core  

Inhibition of activity of GABA transporter GAT1 by δ-opioid receptor [PDF]

, 2012
Analgesia is a well-documented effect of acupuncture. A critical role in pain sensation plays the nervous system, including the GABAergic system and opioid receptor (OR) activation.
Fucke, Thomas, Schwarz, Wolfgang, Xu, Nanjie, Pu, Lu, Pei, Gang, Gu, Quanbao, Xia, Peng, Ren, Shuanglai   +7 more
core   +1 more source

The Rural Opioid Initiative Consortium description: providing evidence to Understand the Fourth Wave of the Opioid Crisis

, 2022
OBJECTIVE: To characterize and address the opioid crisis disproportionately impacting rural U.S. regions. METHODS: The Rural Opioid Initiative (ROI) is a two-phase project to collect and harmonize quantitative and qualitative data and develop tailored ...
Stopka, Thomas J., Friedmann, Peter D., Feinberg, Judith, Westergaard, Ryan P., Tsui, Judith I., Cooper, Hannah L. F., Fredericksen, Rob, Rudolph|, Abby E. Rudolph, Joseph A. C. Delaney, Pho, Mai T., Thomas J. Stopka, Allen, Todd M., P. Todd Korthuis, Todd M. Allen, Hannah L. F. Cooper, Vivian F. Go, Seal, David W., Young, April M., Smith, Gordon S., Wiley D. Jenkins, Gordon S. Smith, Korthuis, P. T., null null, David W. Seal, Crane, Heidi M., Jenkins, Richard A., Miller, William C., Ryan P. Westergaard, Delaney, Joseph A. C., Jenkins, Wiley D., William A. Zule, Judith I. Tsui, Mai T. Pho, Rob Fredericksen, Judith Feinberg, Heidi M. Crane, Rudolph, Abby E., Nance, Robin M., Richard A. Jenkins, Robin M. Nance, Whitney, Bridget M., William C. Miller, Go, Vivian F., Bridget M. Whitney, April M. Young, Peter D. Friedmann, Rudolph, Abby, Korthuis, P. Todd, Zule, William A.   +49 more
core   +1 more source