Results 51 to 60 of about 10,513,249 (295)

Prescription Drug Monitoring Programs and Prescription Opioid-Related Outcomes in the United States. [PDF]

, 2023
Prescription drug monitoring programs (PDMPs) are a crucial component of federal and state governments' response to the opioid epidemic. Evidence about the effectiveness of PDMPs in reducing prescription opioid-related adverse outcomes is mixed.
Puac-Polanco, Victor, Li, Guohua, Chihuri, Stanford, Keyes, Katherine M, Fink, David S, Cerdá, Magdalena   +5 more
core   +1 more source

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

Advanced Science, EarlyView.
Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan, Peiyi Li, Yufeng Chen, Zishan Dong, Yuanyuan Li, Boyu Liu, Yan Tai, Chuan Wang, Jianqiao Fang, Chengyu Yin, Boyi Liu   +10 more
wiley   +1 more source

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

Advanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi, Guangying Li, Qian Yang, Rusun Liu, Linghan Gu, Mingmei Wang, John L. Waddington, Fuhai Ji, Xuechu Zhen   +8 more
wiley   +1 more source

Reducing opioid-related deaths in the UK [PDF]

, 2016
This independent report by the Advisory Council on the Misuse of Drugs investigates the increase of drug-related deaths in the UK. It looks at: - patterns and trends in opioid-related deaths - causes and drivers of trends in opioid-related deaths
Dale-Perera, Annette, Iversen, Les, Stevens, Alex   +2 more
core  

Hederagenin Attenuates Morphine Addiction via GABAA1‐Mediated Modulation of Ca2+–CaMK–CREB Signaling in Ventral Tegmental Dopaminergic Neurons

Advanced Science, EarlyView.
Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Hongyang Jiang, Ziting Zhou, Nannan Xue, Jiasi Deng, Yuanyuan Zhou, Xinying Lv, Yuxuan Wang, Yi Zhang, Haotian Pan, Geyan Xu, Yinkun Tao, Mengran Li, Xin Cui, Hongyue Ma, Qian Wang, Zhigang Lu   +15 more
wiley   +1 more source

Medical encounters for opioid-related intoxications in Southern Nevada: sociodemographic and clinical correlates [PDF]

, 2016
Despite today's heightened concern over opioid overdose, the lack of population-based data examining clinical and contextual factors associated with opioid use represents a knowledge gap with relevance to prevention and treatment interventions. We sought
Wei Yang, Iser, Joseph P., Joseph P. Iser, Feng, Jing, Jing Feng, Yang, Wei   +5 more
core   +2 more sources

qcGEM: A Graph‐Based Molecular Representation With Quantum Chemistry Awareness

Advanced Science, EarlyView.
In this work, we introduce qcGEM, a quantum‐chemistry‐aware graph‐based embedding of molecules that incorporates physical priors into molecular representation learning. Through a specially designed model architecture to adequately process quantum chemistry information as well as three‐dimensional molecular geometry, qcGEM provides a compact, physics ...
Haoyu Wang, Ziyan Zhang, Swee Hong Ng, Haipeng Gong   +3 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Personality and attention bias in adults with a history of childhood trauma, and attenuating effects of mu-opioid agonist buprenorphine on attention bias [PDF]

, 2011
The current study compared personality characteristics and cognitive functioning (specifically, attentional bias) in a sample of adults who had experienced childhood trauma (the Trauma group) and a matched healthy control group.
Christ, Bjorn U
core   +1 more source

Does a state mandate translate into jail policy? Evidence from a policy surveillance study of opioid use disorder care in Colorado jails

Health & Justice
Background People with opioid use disorder (OUD) are disproportionately represented in US jails, yet access to evidence-based treatment remains limited.
Paul J Christine, Jarratt D Pytell, Alena Gabrielson, Selena Muñoz-Jones, Betsy Craft, Hayley Rotello, Ingrid A Binswanger, Katherine LeMasters   +7 more
doaj   +1 more source