Results 51 to 60 of about 144,800 (349)

The association of criminal justice supervision setting with overdose mortality: a longitudinal cohort study. [PDF]

, 2020
Background and aimsDespite the high prevalence of substance use among people in the US criminal justice system, little is known about the incidence of overdose mortality by use patterns, drug convictions and supervision setting.
Anderson R. N., Aos S., Bronson J., Center for Substance Abuse Treatment, Kaeble D., Kaeble D., Michigan Judicial Institute, National Center for Health Statistics, Zeng Z.   +8 more
core   +2 more sources

Leveraging the role of community pharmacists in the prevention, surveillance, and treatment of opioid use disorders

Addiction Science & Clinical Practice, 2019
The global rise in opioid-related harms has impacted the United States severely. Current efforts to manage the opioid crisis have prompted a re-evaluation of many of the existing roles in the healthcare system, in order to maximize their individual ...
Paxton Bach, Daniel Hartung
doaj   +1 more source

Neuropharmacological targets for drug action in vestibular sensory pathways [PDF]

, 2017
The use of pharmacological agents is often the preferred approach to the management of vestibular dysfunction. In the vestibular sensory pathways, the sensory neuroepithelia are thought to be influenced by a diverse number of neuroactive substances that ...
Jones, Timothy A, Lee, Choongheon
core   +3 more sources

Acute opioid overdose in pediatric patients

Journal of the American College of Emergency Physicians Open
Recent increases in pediatric and adolescent opioid fatalities mandate an urgent need for early consideration of possible opioid exposure and specific diagnostic and management strategies and interventions tailored to these unique populations.
Stephen Sandelich, Gwen Hooley, George Hsu, Emily Rose, Tim Ruttan, Evan S. Schwarz, Erin Simon, Carmen Sulton, Jessica Wall, Ann M Dietrich   +9 more
doaj   +1 more source

Bread and other edible agents of mental disease [PDF]

, 2016
Perhaps because gastroenterology, immunology, toxicology, and the nutrition and agricultural sciences are outside of their competence and responsibility, psychologists and psychiatrists typically fail to appreciate the impact that food can have on their ...
BRESSAN, PAOLA, KRAMER, PETER
core   +1 more source

Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers

Advanced Functional Materials, EarlyView.
A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley   +1 more source

Global Overview of Drug Demand and Supply: Latest Trends, Cross-cutting Issues [PDF]

, 2017
An estimated quarter of a billion people, or around 5 per cent of the global adult population, used drugs at least once in 2015. Even more worrisome is the fact that about 29.5 million of those drug users, or 0.6 per cent of the global adult population ...

core  

Neurobehavioral consequences of chronic intrauterine opioid exposure in infants and preschool children: a systematic review and meta-analysis [PDF]

, 2014
<b>Background</b><p></p> It is assumed within the accumulated literature that children born of pregnant opioid dependent mothers have impaired neurobehavioral function as a consequence of chronic intrauterine opioid use.<p>&
A Baldacchino, A Liberati, A Ornoy, A Sameroff, A Verdejo-Garcia, AJ Dunlop, Alex Baldacchino, American Psychiatric Association, B Hanson, BJ Cleary, Britannica, C Konijnenberg, C Konijnenberg, Colin McCowan, DE Hutchings, Dennis J Petrie, Department of Health (England) and the devolved administrations, DF Stroup, E Rotheram-Fuller, E Strauss, EK Emory, FM Wolf, GJ Demakis, H Cooper, HC Steinhausen, HE Jones, HE Jones, I Fihrer, I van Beusekom, IM Bernstein, J Cohen, J Cohen, J Keegan, J Kimber, J Prosser, JE Hunter, JN Whitham, JP Higgins, K Spiteri Cornish, Kathleen Arbuckle, KB Walhovd, KD Ersche, KK Zakzanis, L Manchikanti, L McGlone, LV Hedges, LV Hedges, LW Anderson, M Borenstein, M Borenstein, M Connock, M Farrell, M Grattan, M Pirastu, MD Lezak, MM de Cubas, National Collaborating Centre for Methods and Tools, NICE, NICHD, PS Bauman, R Bunikowski, R Cornish, R Hamilton, R King, RE Johnson, RG Orwin, RJ Sternberg, RW Hunt, S Darke, S Minozzi, S Salo, S Simeons, S Soepatmi, S Tong, Scottish Government, SL Grace, SL Hans, SL Hans, SM Petterson, SM Quinhana, SR Kandall, TB Huedo-Medina, TJ Ornstein, TS Rosen, V Moe, WH Organization, WK Lombardo   +86 more
core   +12 more sources

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

Advanced Science, EarlyView.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun, Jia‐Jia Wang, Xiang‐Yu Li, Xin‐Yi Lin, Juan Li, Qiu‐Tong Yu, Zi‐Han Wang, Xue‐Ping Gao, Lei Jin, Wei‐Ke Li, Tian‐Lin Cheng, Juan Deng   +11 more
wiley   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source