Results 41 to 50 of about 369,622 (191)

The Process of Healing from Opioid Addiction [PDF]

open access: yes, 2021
In the last several years, rates and concern about opioid addiction in the US have intensified. It is estimated that more than 130 people die every day from opioid-related drug overdoses (National Center for Health Statistics, 2017).
McDonald, James Edward
core  

A computational strategy for finding novel targets and therapeutic compounds for opioid dependence.

open access: yesPLoS ONE, 2018
Opioids are widely used for treating different types of pains, but overuse and abuse of prescription opioids have led to opioid epidemic in the United States. Besides analgesic effects, chronic use of opioid can also cause tolerance, dependence, and even
Xiaojun Wu   +6 more
doaj   +1 more source

Methadone Maintenance Therapy (MMT) and Alternatives in Opioid Use Disorder: Reviewing the latest advancements, outcomes, and challenges in substitutional therapy for opioid addiction - literature review

open access: yesJournal of Education, Health and Sport
Introduction and Purpose: Opioid addiction is a serious challenge for public health worldwide, and methadone maintenance therapy (MMT) is a key therapeutic approach.
Karolina Koszyczarek   +7 more
doaj   +1 more source

Use and misuse of opioid agonists in opioid addiction

open access: yesCleveland Clinic Journal of Medicine, 2017
Although methadone (an opioid agonist) and buprenorphine (a partial opioid agonist) have evidence to support their use in treating opioid use disorder, they remain misunderstood and underutilized. In this article, we outline the risks and benefits of using these drugs as maintenance therapy in opioid-dependent patients.
Vania, Modesto-Lowe   +3 more
openaire   +2 more sources

The Extract of Corydalis yanhusuo Prevents Morphine Tolerance and Dependence

open access: yesPharmaceuticals, 2021
The opioid epidemic was triggered by an overprescription of opioid analgesics. In the treatment of chronic pain, repeated opioid administrations are required which ultimately lead to tolerance, physical dependence, and addiction.
Lamees Alhassen   +6 more
doaj   +1 more source

A review of opioid addiction genetics [PDF]

open access: yesCurrent Opinion in Psychology, 2019
Opioid use disorder (OUD) affects millions of people worldwide and the risk of developing the disorder has a significant genetic component according to twin and family studies. Identification of the genetic variants underlying this inherited risk has focused on two different methods: candidate gene studies and genome-wide association studies (GWAS ...
Richard C Crist   +2 more
openaire   +2 more sources

OPRM1 A118G Polymorphisms and Its Role in Opioid Addiction: Implication on Severity and Treatment Approaches

open access: yesPharmacogenomics and Personalized Medicine, 2019
Malik Mumtaz Taqi,1 Muhammad Faisal,2,3 Hadar Zaman4 1Division of Mental Health and Addiction, University of Oslo, Oslo, Norway; 2Faculty of Health Studies, University of Bradford, Bradford, UK; 3Bradford Institute for Health Research, Bradford Teaching ...
Taqi MM, Faisal M, Zaman H
doaj  

Prevention of Opioid Addiction

open access: yesJournal of Biomedical Research & Environmental Sciences, 2021
Opioid addiction is classified as a Substance Use Disorder (SUD), a complex and chronic health condition with physical, social, and psychological consequences. While there is no cure for it, we present a novel approach towards preventing a hallmark feature of addiction-- the opiate withdrawal syndrome.
Ihezie, Stephanie A, Dafny, Nachum
openaire   +1 more source

Opioids, stress and addiction: From stress-induced analgesia to opioid heterodimers with extraordinary analgesic efficacy and without the side effects of traditional opioids

open access: yesAddiction Neuroscience
The Special Issue on Stress and Addiction is concerned with interrelationships between environmental stimuli such as stress and endogenous opioid systems that lead to addiction and other behaviors.
Giuseppe Cataldo   +2 more
doaj   +1 more source

MicroRNAs in opioid addiction: elucidating evolution.

open access: yesFrontiers in Genetics, 2012
Three reviews in the Frontiers Research Topic Non-Coding RNA and Addiction (Zheng et al 2012; He and Wang 2012; Rodriguez 2012 in press), grouped under the chapter MicroRNAs and Morphine, focus on the contribution of microRNAs to opioid abuse.
Emily Jane Wood, Leonard eLipovich
doaj   +1 more source

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