Results 191 to 200 of about 292,142 (337)

Discontinuation of SGLT2i After a Urogenital Infection: A Population‐Based Matched Cohort Study of Patients With Type 2 Diabetes

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Sodium‐glucose cotransporter 2 inhibitors (SGLT2is) improve glycaemic control and cardiorenal outcomes in Type 2 diabetes, particularly in patients at elevated cardiovascular and kidney risk, yet discontinuation following infections appears common.
Christine Ljungberg, Mette Nørgaard, Christina Vandenbroucke‐Grauls, Michael Dalager‐Pedersen, Henrik Toft Sørensen, Reimar Wernich Thomsen   +5 more
wiley   +1 more source

Analgesic effects of alpha‐2‐adrenoreceptor agonists in equine medicine: systemic, spinal, and local applications

Equine Veterinary Education, EarlyView.
Summary Alpha‐2‐adrenoreceptor agonists provide analgesia when used as sole agents but can also be used in combination with other drugs for their additive and potentially synergistic effects. Further, because of their effects on blood flow, alpha‐2‐adrenoreceptor agonists act to extend and perhaps intensify the effects of drugs, such as local ...
J. Brandly, J. R. Page, J. A. E. Hubbell, W. W. Muir III, K. Hopster   +4 more
wiley   +1 more source

Spatiotemporal dynamics of β‐arrestin‐mediated Src activation in 5‐HT7 receptor signaling pathway

The FEBS Journal, EarlyView.
GPCRs induce distinct cellular responses via G protein‐ or β‐arrestin‐mediated signaling pathways. This study revealed that β‐arrestin‐biased 5‐HT7R ligand induces slow, sustained Src activation, contrasting with transient G protein‐mediated activation.
Hyunbin Kim, Yong Woo Lee, Huimin Lee, Eunseo Park, Jieon Lee, Hae Nim Lee, Kyeong‐Man Kim, Hyunah Choo, Jihye Seong   +8 more
wiley   +1 more source

Fish welfare in a changing world: New developments and current challenges

Journal of Fish Biology, EarlyView.
Abstract The welfare of non‐human animals is central to ethical discussions on animal use, with increasing attention to fish welfare across research, aquaria, aquaculture, and fisheries. This paper reviews current theoretical approaches to animal welfare and recent advances in defining and assessing fish welfare since the seminal paper by Huntingford ...
Sonia Rey Planellas, João L. Saraiva, Eliane Gonçalves‐de‐Freitas, Pablo Arechavala‐Lopez, Bernice Bovenkerk, Michael Breen, Steven J. Cooke, Martin Føre, Lene Northwood, Lars Helge Stien, Sunil Kadri, Chris Noble, Jonatan Nilsson, Fernando Rodriguez, Cosme Salas, Peter Sandøe, Hans van de Vis   +16 more
wiley   +1 more source

Postpartum retention in opioid agonist treatment for opioid dependence: A population-based cohort study. [PDF]

Arch Womens Ment Health
Zhou J, Varney B, Jones N, Bharat C, Degenhardt L, Havard A, Tran DT.   +6 more
europepmc   +1 more source

Association Between Cholinesterase Inhibitor‐Overactive Bladder Antimuscarinic Prescribing Cascade and Risk of Delirium and Falls Among Individuals Living With Dementia

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Prescribing cascades occur when cholinesterase inhibitor (ChEI)‐induced urinary incontinence is misinterpreted as a new condition, leading to overactive bladder (OAB) antimuscarinic initiation. We evaluated whether the ChEI‐OAB antimuscarinic prescribing cascade was associated with delirium or falls compared with mirabegron in older
Sarah Beth Tucker, Bryan L. Love, Chijioke M. Okeke, Erin D. Zwick, Chengwen Teng, Jingkai Wei, Ibraheem M. Karaye, Saud Alsahali, Krithika Rajagopalan, Ismaeel Yunusa   +9 more
wiley   +1 more source

Trends in Opioid Agonist Treatment for Opioid Dependence During Pregnancy: A Population-Based Study in New South Wales 2005-2021. [PDF]

Drug Alcohol Rev
Tran DT, Varney B, Jones N, Bharat C, Brett J, Oei JL, Pearson SA, Degenhardt L, Havard A.   +8 more
europepmc   +1 more source

Conducting Medication Reviews: A Comparative Study Between ChatGPT‐4 and Healthcare Professionals

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background The increasing prevalence of patients with hyperpolypharmacy (> 10 medications) has made medication reviews increasingly complex. ChatGPT‐4‐Turbo (ChatGPT), a large language model, has demonstrated potential in healthcare applications and could potentially support medication reviews.
Simone M. K. ten Hoope, Sabrina Marongiu, Carl E. H. Siegert, Eibert R. Heerdink, Marjo J. A. Janssen, Fatma Karapinar‐Çarkit   +5 more
wiley   +1 more source

Association between the location of Opioid Agonist Treatment (OAT) providers and heroin-related ambulance attendances. [PDF]

Subst Abuse Treat Prev Policy
Hall N, Rowland B, Ogeil RP, Loos R, Nehme Z, Lubman DI.   +5 more
europepmc   +1 more source

Primary Care Practitioners' Approaches to Deprescribing Opioids for Older Adults With Chronic Pain: A Qualitative Analysis

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Risks related to long‐term opioid therapy for chronic pain are high and may increase over time with aging. Deprescribing may be a beneficial intervention for older adults prescribed chronic opioids. Methods Semi‐structured interviews with hypothetical clinical cases of older adults prescribed opioids for chronic pain: (1) low‐risk ...
Brianna X. Wang, Julia H. Lindenberg, Shoshana J. Herzig, Mara A. Schonberg, Timothy S. Anderson   +4 more
wiley   +1 more source